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516 hedge funds and large institutions have $21.2B invested in Insmed in 2025 Q2 according to their latest regulatory filings, with 131 funds opening new positions, 165 increasing their positions, 189 reducing their positions, and 52 closing their positions.

New
Increased
Maintained
Reduced
Closed

152% more first-time investments, than exits

New positions opened: 131 | Existing positions closed: 52

38% more capital invested

Capital invested by funds: $15.3B → $21.2B (+$5.85B)

17% more funds holding

Funds holding: 441516 (+75)

6% more funds holding in top 10

Funds holding in top 10: 3133 (+2)

5.23% more ownership

Funds ownership: 110.29%115.51% (+5.2%)

13% less repeat investments, than reductions

Existing positions increased: 165 | Existing positions reduced: 189

16% less call options, than puts

Call options by funds: $300M | Put options by funds: $356M

Holders
516
Holders Change
+75
Holders Change %
+17.01%
% of All Funds
6.79%
Holding in Top 10
33
Holding in Top 10 Change
+2
Holding in Top 10 Change %
+6.45%
% of All Funds
0.43%
New
131
Increased
165
Reduced
189
Closed
52
Calls
$300M
Puts
$356M
Net Calls
-$56.3M
Net Calls Change
+$15.7M
Name Holding Trade Value Shares
Change
Change in
Stake
PAI
51
Palo Alto Investors
California
$87.1M -$9.33M -122,040 -12%
MC
52
Maverick Capital
Texas
$80.9M +$29M +379,008 +89%
Loomis, Sayles & Company
53
Loomis, Sayles & Company
Massachusetts
$79.9M -$16.5M -215,897 -21%
Raymond James Financial
54
Raymond James Financial
Florida
$79M +$28.7M +375,614 +92%
BNP Paribas Financial Markets
55
BNP Paribas Financial Markets
France
$75.9M +$22.4M +292,497 +63%
AGP
56
Artia Global Partners
Florida
$75.8M +$33.2M +434,473 +137%
Fiera Capital (Canada)
57
Fiera Capital (Canada)
Quebec, Canada
$75.3M +$12.9M +168,800 +29%
HF
58
HRT Financial
New York
$73.4M +$55.8M +729,597 New
NM
59
NWI Management
New York
$72.5M +$20.6M +270,000 +60%
Jennison Associates
60
Jennison Associates
New York
$72M -$2.5M -32,707 -4%
DM
61
Deerfield Management
New York
$70.5M +$18.6M +242,700 +53%
PCH
62
Polar Capital Holdings
United Kingdom
$70.2M -$2.35M -30,795 -4%
UBS AM
63
UBS AM
Illinois
$70M +$12M +156,477 +29%
NHAS
64
Novo Holdings A/S
Denmark
$68.4M -$3.42M -44,666 -6%
PA
65
Perceptive Advisors
New York
$65.4M +$10.8M +140,952 +28%
Alyeska Investment Group
66
Alyeska Investment Group
Illinois
$60.8M -$10M -131,298 -18%
N
67
Nuveen
North Carolina
$59.3M -$43.5M -569,107 -49%
Brown Advisory
68
Brown Advisory
Maryland
$58.4M -$7.08M -92,604 -14%
Ensign Peak Advisors
69
Ensign Peak Advisors
Utah
$56.8M -$1.91M -25,010 -4%
CAM
70
Cormorant Asset Management
Massachusetts
$54.3M +$1.15M +15,000 +3%
RSCM
71
Rock Springs Capital Management
Maryland
$52.8M +$696K +9,100 +2%
LFCM
72
Long Focus Capital Management
Puerto Rico
$52.4M -$8.46M -110,600 -18%
Alkeon Capital Management
73
Alkeon Capital Management
New York
$50.3M +$38.2M +500,000 New
Point72 Asset Management
74
Point72 Asset Management
Connecticut
$49.4M +$37.5M +490,667 New
AAA
75
Affinity Asset Advisors
New York
$47.8M +$25.6M +335,000 +239%

INSM Hedge Fund Activity: Q2 2025 in Review

516 of the 7,595 institutional investors tracked by Wall St. Rank reported a position in Insmed (INSM) for Q2 2025, worth a combined $21.2B — up 38% from $15.3B a quarter earlier.

Buyers outnumbered sellers: 131 funds opened new INSM positions and 52 closed out — a net gain of 79 holders — while 165 added to existing stakes and 189 trimmed.

The largest buyer was JP Morgan Chase, adding an estimated $710M. The largest seller was BlackRock, cutting an estimated $375M.

  • 516 institutional investors held Insmed (INSM) as of Q2 2025, up from 441 in Q1 2025.
  • Funds reported $21.2B of Insmed stock for Q2 2025, up 38% quarter-over-quarter.
  • 131 funds opened new Insmed positions in Q2 2025 and 52 closed out, a net change of +79 holders.
  • The largest Insmed buyer in Q2 2025 was JP Morgan Chase, an estimated $710M added.
  • The largest Insmed seller in Q2 2025 was BlackRock, an estimated $375M sold.

Based on aggregated 13F filings for Q2 2025.