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516 hedge funds and large institutions have $21.2B invested in Insmed in 2025 Q2 according to their latest regulatory filings, with 131 funds opening new positions, 165 increasing their positions, 189 reducing their positions, and 52 closing their positions.

New
Increased
Maintained
Reduced
Closed

152% more first-time investments, than exits

New positions opened: 131 | Existing positions closed: 52

38% more capital invested

Capital invested by funds: $15.3B → $21.2B (+$5.85B)

17% more funds holding

Funds holding: 441516 (+75)

6% more funds holding in top 10

Funds holding in top 10: 3133 (+2)

5.23% more ownership

Funds ownership: 110.29%115.51% (+5.2%)

13% less repeat investments, than reductions

Existing positions increased: 165 | Existing positions reduced: 189

16% less call options, than puts

Call options by funds: $300M | Put options by funds: $356M

Holders
516
Holders Change
+75
Holders Change %
+17.01%
% of All Funds
6.79%
Holding in Top 10
33
Holding in Top 10 Change
+2
Holding in Top 10 Change %
+6.45%
% of All Funds
0.43%
New
131
Increased
165
Reduced
189
Closed
52
Calls
$300M
Puts
$356M
Net Calls
-$56.3M
Net Calls Change
+$15.7M
Name Holding Trade Value Shares
Change
Change in
Stake
IHAM
26
Integral Health Asset Management
New York
$161M +$3.82M +50,000 +3%
Pictet Asset Management
27
Pictet Asset Management
Switzerland
$156M -$35.1M -459,701 -23%
Lord, Abbett & Co
28
Lord, Abbett & Co
New Jersey
$156M +$14.9M +195,272 +14%
Citadel Advisors
29
Citadel Advisors
Florida
$154M +$88.6M +1,158,462 +309%
OAG
30
Orbis Allan Gray
Bermuda
$153M +$117M +1,524,134 New
ClearBridge Investments
31
ClearBridge Investments
New York
$143M -$30.9M -404,166 -22%
Jane Street
32
Jane Street
New York
$136M +$93.9M +1,228,335 +986%
Principal Financial Group
33
Principal Financial Group
Iowa
$136M -$31.1M -407,346 -23%
AllianceBernstein
34
AllianceBernstein
Tennessee
$135M -$82.6M -1,080,301 -45%
Westfield Capital Management
35
Westfield Capital Management
Massachusetts
$135M -$5.15M -67,321 -5%
Charles Schwab
36
Charles Schwab
California
$131M -$23.2M -303,087 -19%
GKIM
37
GW&K Investment Management
Massachusetts
$128M -$7.91M -103,410 -8%
Bank of America
38
Bank of America
North Carolina
$123M -$9.65M -126,262 -9%
Bank of New York Mellon
39
Bank of New York Mellon
New York
$121M +$3.11M +40,723 +4%
EAM
40
Eventide Asset Management
Massachusetts
$120M +$1.13M +14,819 +1%
Fidelity International
41
Fidelity International
Bermuda
$117M -$93.6M -1,224,737 -51%
Wellington Management Group
42
Wellington Management Group
Massachusetts
$117M -$4.81M -62,928 -5%
Macquarie Group
43
Macquarie Group
Australia
$114M -$94.1M -1,231,182 -52%
Marshall Wace
44
Marshall Wace
United Kingdom
$112M +$31.9M +417,124 +60%
Qube Research & Technologies (QRT)
45
Qube Research & Technologies (QRT)
United Kingdom
$109M +$82.7M +1,082,050 New
Morgan Stanley
46
Morgan Stanley
New York
$105M -$1.21M -15,865 -1%
SPPAM
47
Summit Partners Public Asset Management
Massachusetts
$102M +$23.3M +304,571 +43%
Northern Trust
48
Northern Trust
Illinois
$97.6M -$54.6M -714,038 -42%
HRCM
49
Hood River Capital Management
Florida
$90.5M -$50.4M -658,683 -42%
TCM
50
TimesSquare Capital Management
New York
$87.9M -$14.6M -190,657 -18%

INSM Hedge Fund Activity: Q2 2025 in Review

516 of the 7,595 institutional investors tracked by Wall St. Rank reported a position in Insmed (INSM) for Q2 2025, worth a combined $21.2B — up 38% from $15.3B a quarter earlier.

Buyers outnumbered sellers: 131 funds opened new INSM positions and 52 closed out — a net gain of 79 holders — while 165 added to existing stakes and 189 trimmed.

The largest buyer was JP Morgan Chase, adding an estimated $710M. The largest seller was BlackRock, cutting an estimated $375M.

  • 516 institutional investors held Insmed (INSM) as of Q2 2025, up from 441 in Q1 2025.
  • Funds reported $21.2B of Insmed stock for Q2 2025, up 38% quarter-over-quarter.
  • 131 funds opened new Insmed positions in Q2 2025 and 52 closed out, a net change of +79 holders.
  • The largest Insmed buyer in Q2 2025 was JP Morgan Chase, an estimated $710M added.
  • The largest Insmed seller in Q2 2025 was BlackRock, an estimated $375M sold.

Based on aggregated 13F filings for Q2 2025.