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516 hedge funds and large institutions have $21.2B invested in Insmed in 2025 Q2 according to their latest regulatory filings, with 131 funds opening new positions, 165 increasing their positions, 189 reducing their positions, and 52 closing their positions.

New
Increased
Maintained
Reduced
Closed

152% more first-time investments, than exits

New positions opened: 131 | Existing positions closed: 52

38% more capital invested

Capital invested by funds: $15.3B → $21.2B (+$5.85B)

17% more funds holding

Funds holding: 441516 (+75)

6% more funds holding in top 10

Funds holding in top 10: 3133 (+2)

5.23% more ownership

Funds ownership: 110.29%115.51% (+5.2%)

13% less repeat investments, than reductions

Existing positions increased: 165 | Existing positions reduced: 189

16% less call options, than puts

Call options by funds: $300M | Put options by funds: $356M

Holders
516
Holders Change
+75
Holders Change %
+17.01%
% of All Funds
6.79%
Holding in Top 10
33
Holding in Top 10 Change
+2
Holding in Top 10 Change %
+6.45%
% of All Funds
0.43%
New
131
Increased
165
Reduced
189
Closed
52
Calls
$300M
Puts
$356M
Net Calls
-$56.3M
Net Calls Change
+$15.7M
Name Holding Trade Value Shares
Change
Change in
Stake
OSAM
276
O'Shaughnessy Asset Management
Connecticut
$1.14M +$115K +1,510 +15%
Amundi
277
Amundi
France
$1.13M +$875K +11,445 +21,194%
SA
278
Sanctuary Advisors
Indiana
$1.12M +$551K +7,201 +185%
PAS
279
Park Avenue Securities
New York
$1.12M +$3.98K +52 +0.5%
EFM
280
E Fund Management
China
$1.1M -$206K -2,692 -20%
Neuberger Berman Group
281
Neuberger Berman Group
New York
$1.1M -$12.7M -165,738 -94%
LPC
282
Lion Point Capital
New York
$1.07M -$1.52M -19,850 -65%
N
283
Natixis
France
$1.07M +$814K +10,648 New
MIM
284
MetLife Investment Management
New Jersey
$1.07M -$6.85M -89,621 -89%
BMSSC
285
B. Metzler seel. Sohn & Co
Germany
$1.06M
LIP
286
Lighthouse Investment Partners
Florida
$1.01M +$765K +10,000 New
US Bancorp
287
US Bancorp
Minnesota
$981K -$120K -1,571 -14%
GCP
288
GSA Capital Partners
United Kingdom
$978K +$743K +9,721 New
KeyBank National Association
289
KeyBank National Association
Ohio
$952K +$90.1K +1,179 +14%
URS
290
Utah Retirement Systems
Utah
$950K +$721K +9,436 New
WPW
291
Waldron Private Wealth
Pennsylvania
$886K
MSRPS
292
Maryland State Retirement & Pension System
Maryland
$873K +$663K +8,676 New
SAM
293
Shell Asset Management
Netherlands
$865K -$118K -1,543 -15%
Thrivent Financial for Lutherans
294
Thrivent Financial for Lutherans
Minnesota
$861K +$654K +8,557 New
Osaic Holdings
295
Osaic Holdings
Arizona
$855K +$307K +4,015 +85%
BFA
296
Beacon Financial Advisory
Ohio
$853K -$16.4K -215 -2%
SCI
297
S&CO Inc
Massachusetts
$835K +$635K +8,300 New
VPIM
298
Vanguard Personalized Indexing Management
California
$813K -$8.95K -117 -1%
Parnassus Investments
299
Parnassus Investments
California
$798K +$606K +7,930 New
DC
300
Diametric Capital
Massachusetts
$781K +$593K +7,757 New

INSM Hedge Fund Activity: Q2 2025 in Review

516 of the 7,595 institutional investors tracked by Wall St. Rank reported a position in Insmed (INSM) for Q2 2025, worth a combined $21.2B — up 38% from $15.3B a quarter earlier.

Buyers outnumbered sellers: 131 funds opened new INSM positions and 52 closed out — a net gain of 79 holders — while 165 added to existing stakes and 189 trimmed.

The largest buyer was JP Morgan Chase, adding an estimated $710M. The largest seller was BlackRock, cutting an estimated $375M.

  • 516 institutional investors held Insmed (INSM) as of Q2 2025, up from 441 in Q1 2025.
  • Funds reported $21.2B of Insmed stock for Q2 2025, up 38% quarter-over-quarter.
  • 131 funds opened new Insmed positions in Q2 2025 and 52 closed out, a net change of +79 holders.
  • The largest Insmed buyer in Q2 2025 was JP Morgan Chase, an estimated $710M added.
  • The largest Insmed seller in Q2 2025 was BlackRock, an estimated $375M sold.

Based on aggregated 13F filings for Q2 2025.