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Structure Therapeutics

197 hedge funds and large institutions have $4.58B invested in Structure Therapeutics in 2025 Q4 according to their latest regulatory filings, with 71 funds opening new positions, 52 increasing their positions, 62 reducing their positions, and 27 closing their positions.

New
Increased
Maintained
Reduced
Closed

more funds holding in top 10

Funds holding in top 10:

more call options, than puts

Call options by funds: $ | Put options by funds: $

more capital invested

Capital invested by funds: $ → $

more first-time investments, than exits

New positions opened: | Existing positions closed:

26% more funds holding

Funds holding: 156197 (+41)

10.07% more ownership

Funds ownership: 98.33%108.4% (+10%)

16% less repeat investments, than reductions

Existing positions increased: 52 | Existing positions reduced: 62

Holders
197
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
16
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$62.6M
Puts
$18.2M
Net Calls
Net Calls Change

Top Sellers

1 -$45.8M
2 -$42.5M
3 -$38.3M
4
Invesco
Invesco
Georgia
-$18M
5
CCM
Catalio Capital Management
New York
-$16.3M
Name Holding Trade Value Shares
Change
Change in
Stake
EP
51
Eversept Partners
New York
$8.87M
WP
52
Woodline Partners
California
$8.62M
Renaissance Technologies
53
Renaissance Technologies
New York
$8.01M
Alyeska Investment Group
54
Alyeska Investment Group
Illinois
$8M
JFG
55
Jefferies Financial Group
New York
$7.16M
RI
56
RTW Investments
New York
$6.96M
JG
57
Jain Global
New York
$6.95M
SFI
58
Susquehanna Fundamental Investments
Pennsylvania
$6.93M
Two Sigma Investments
59
Two Sigma Investments
New York
$6.65M
SC
60
SummitTX Capital
Texas
$6.58M
NCM
61
NEXTBio Capital Management
California
$6.57M
Manulife (Manufacturers Life Insurance)
62
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$6.53M
Simplex Trading
63
Simplex Trading
Illinois
$6.45M
BC
64
Birchview Capital
Vermont
$6.26M
BGI
65
B Group Inc
Texas
$6.26M
SCM
66
Soleus Capital Management
Connecticut
$6.26M
TI
67
Trexquant Investment
Connecticut
$6.26M
PIM
68
Platinum Investment Management
Australia
$6.11M
BHCM
69
Brevan Howard Capital Management
Jersey
$5.96M
PCM
70
Peregrine Capital Management
Minnesota
$5.86M
Universal-Beteiligungs- und Servicegesellschaft
71
Universal-Beteiligungs- und Servicegesellschaft
Germany
$5.78M
NAMI
72
Nomura Asset Management International
Pennsylvania
$5.75M
Verition Fund Management
73
Verition Fund Management
Connecticut
$5.44M
BCM
74
Boxer Capital Management
California
$5.22M
PHS
75
PFM Health Sciences
California
$4.75M