Two Sigma Investments
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Two Sigma Investments’s Structure Therapeutics GPCR Stock Holding History

Two Sigma Investments’s Portfolio GPCR Stock Details GPCR Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$8.74M Buy
181,415
+85,872
+90% +$5.88M 0.01% 1492
2025
Q4 		$6.65M Sell
95,543
-87,368
-48% -$3.57M 0.01% 1448
2025
Q3 		$5.12M Buy
+182,911
New +$3.64M 0.01% 1443

Other funds holding GPCR

Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
Wellington Management Group
Wellington Management Group Boston, Massachusetts $535B AUM 26.23% 1-Year Est. Return
ACA
Avoro Capital Advisors New York $10.2B AUM 149.19% 1-Year Est. Return
Janus Henderson Group
Janus Henderson Group London, United Kingdom $209B AUM 37.72% 1-Year Est. Return
DTC
Deep Track Capital Greenwich, Connecticut $6.12B AUM 144% 1-Year Est. Return
BI
BVF Inc San Francisco, California $3.14B AUM 249.53% 1-Year Est. Return
Morgan Stanley
Morgan Stanley New York $1.66T AUM 25.57% 1-Year Est. Return
T. Rowe Price Associates
T. Rowe Price Associates Baltimore, Maryland $865B AUM 30.76% 1-Year Est. Return
Principal Financial Group
Principal Financial Group Des Moines, Iowa $187B AUM 18.48% 1-Year Est. Return
DCM
Driehaus Capital Management Chicago, Illinois $13.6B AUM 173.98% 1-Year Est. Return

Two Sigma Investments's GPCR Position: Q1 2026 in Review

Two Sigma Investments increased its Structure Therapeutics (GPCR) stake by 90% in Q1 2026, buying an estimated $5.88M and bringing the position to 181,415 shares worth $8.74M. The position accounts for 0.01% of the portfolio, ranked #1492.

Two Sigma Investments first reported a position in GPCR in Q3 2025 and has held it in 3 quarters since. 196 funds tracked by Wall St. Rank hold GPCR as of Q1 2026.

  • Two Sigma Investments held 181,415 shares of Structure Therapeutics worth $8.74M as of Q1 2026.
  • Two Sigma Investments bought 85,872 Structure Therapeutics shares in Q1 2026, an estimated $5.88M.
  • Structure Therapeutics made up 0.01% of Two Sigma Investments's portfolio in Q1 2026, its #1492 holding.
  • Two Sigma Investments first reported a position in Structure Therapeutics in Q3 2025 and has held it in 3 quarters since.
  • 196 funds tracked by Wall St. Rank held Structure Therapeutics as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.