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Amicus Therapeutics
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Overview Fund Activity

268 hedge funds and large institutions have $1.83B invested in Amicus Therapeutics in 2025 Q2 according to their latest regulatory filings, with 35 funds opening new positions, 118 increasing their positions, 81 reducing their positions, and 47 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
268
Holders Change
-13
Holders Change %
-4.63%
% of All Funds
3.6%
Holding in Top 10
4
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-20%
% of All Funds
0.05%
New
35
Increased
118
Reduced
81
Closed
47
Calls
$2.41M
Puts
$1.56M
Net Calls
+$846K
Net Calls Change
+$2.68M

Top Buyers

1
VPC
1
Vestal Point Capital
New York
$68.2M
2
D.E. Shaw & Co
2
D.E. Shaw & Co
New York
$36.5M
3
Millennium Management
3
Millennium Management
New York
$42.5M
4
Assenagon Asset Management
4
Assenagon Asset Management
Luxembourg
$20.2M
5
Qube Research & Technologies (QRT)
5
Qube Research & Technologies (QRT)
United Kingdom
$19.9M

Top Sellers

1
PA
1
Perceptive Advisors
New York
$42.5M
2
RG
2
Redmile Group
California
$6.81M
3
American Century Companies
3
American Century Companies
Missouri
$0
4
NHAS
4
Novo Holdings A/S
Denmark
$0
5
JPMorgan Chase & Co
5
JPMorgan Chase & Co
New York
$12.7M
Name Holding Trade Value Shares
Change 		Shares
Change %
RIL
251
Rothschild Investment LLC
Illinois
$1.09K -$516 -90 -32%
AW
252
Avion Wealth
Texas
$1K +$762 +170 +321%
SAM
253
Smartleaf Asset Management
Massachusetts
$990 -$1.73K -292 -64%
BIA
254
Bell Investment Advisors
California
$906 -$17 -3 -2%
AAP
255
Arax Advisory Partners
Colorado
$906 +$499 +87 +123%
SS
256
SBI Securities
Japan
$682 +$23 +4 +3%
PWMG
257
Private Wealth Management Group
New Jersey
$585 +$585 +102 New
HFS
258
Hughes Financial Services
Virginia
$575 +$575 +83 New
KFI
259
Key Financial Inc
Pennsylvania
$573 – – –
PFBT
260
Parkside Financial Bank & Trust
Missouri
$534 -$119 -20 -18%
FFO
261
Fortitude Family Office
Arizona
$464 +$464 +81 New
AssetMark Inc
262
AssetMark Inc
California
$367 -$84.7K -14,778 -100%
GRP
263
Global Retirement Partners
California
$264 +$264 +46 New
FFA
264
Farther Finance Advisors
California
$183 -$252 -44 -58%
BIG
265
Brooklyn Investment Group
New York
$127 -$237 -41 -65%
GI
266
GAMMA Investing
California
$115 -$5.13K -892 -98%
WA
267
WPG Advisers
Maryland
$97 – – –
HNB
268
Huntington National Bank
Ohio
$6 -$234 -39 -98%
American Century Companies
269
American Century Companies
Missouri
– -$31.8M -3,899,228 Closed
NHAS
270
Novo Holdings A/S
Denmark
– -$22.4M -2,750,000 Closed
Aberdeen Group
271
Aberdeen Group
United Kingdom
– -$12.9M -1,586,609 Closed
Man Group
272
Man Group
United Kingdom
– -$8.31M -1,018,301 Closed
IECM
273
Intrinsic Edge Capital Management
Illinois
– -$7.13M -873,900 Closed
OWIM
274
Old West Investment Management
California
– -$3.26M -399,498 Closed
TCA
275
Transcend Capital Advisors
New Jersey
– -$2.97M -364,383 Closed
9 10
11
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