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DFTX

Definium Therapeutics
DFTX

247 hedge funds and large institutions have $1.47B invested in Definium Therapeutics in 2026 Q1 according to their latest regulatory filings, with 69 funds opening new positions, 82 increasing their positions, 52 reducing their positions, and 25 closing their positions.

New
Increased
Maintained
Reduced
Closed

284% more call options, than puts

Call options by funds: $32.5M | Put options by funds: $8.45M

176% more first-time investments, than exits

New positions opened: 69 | Existing positions closed: 25

62% more capital invested

Capital invested by funds: $909M → $1.47B (+$566M)

58% more repeat investments, than reductions

Existing positions increased: 82 | Existing positions reduced: 52

20% more funds holding in top 10

Funds holding in top 10: 5 → 6 (+1)

19% more funds holding

Funds holding: 208 → 247 (+39)

9.4% more ownership

Funds ownership: 68.89% → 78.29% (+9.4%)

Holders
247
Holders Change
+39
Holders Change %
+18.75%
% of All Funds
3.04%
Holding in Top 10
6
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+20%
% of All Funds
0.07%
New
69
Increased
82
Reduced
52
Closed
25
Calls
$32.5M
Puts
$8.45M
Net Calls
+$24M
Net Calls Change
+$11.4M

Top Buyers

1
Fidelity Investments
Fidelity Investments
Massachusetts
+$28M
2
ACH
ArrowMark Colorado Holdings
Colorado
+$27.1M
3
DTC
Deep Track Capital
Connecticut
+$22.5M
4
Janus Henderson Group
Janus Henderson Group
United Kingdom
+$19.4M
5
Citadel Advisors
Citadel Advisors
Florida
+$19.1M

Top Sellers

1
Marshall Wace
Marshall Wace
United Kingdom
-$30.1M
2
Blackstone Inc
Blackstone Inc
New York
-$26.3M
3
TECP
Trails Edge Capital Partners
Georgia
-$14.1M
4
DCM
Driehaus Capital Management
Illinois
-$10.6M
5
RA
Rosalind Advisors
Ontario, Canada
-$10.6M
Name Holding Trade Value Shares
Change 		Change in
Stake
BC
51
BIT Capital
Germany
$5.24M +$4.71M +277,511 New
D.E. Shaw & Co
52
D.E. Shaw & Co
New York
$5.14M -$373K -22,005 -7%
Jane Street
53
Jane Street
New York
$4.92M -$4.68M -275,761 -51%
JP Morgan Chase
54
JP Morgan Chase
New York
$4.63M +$1.88M +110,823 +72%
RA
55
Royce & Associates
New York
$4.42M +$1.19M +70,010 +43%
SGM
56
Seven Grand Managers
New York
$4.25M – – –
BHCM
57
Brevan Howard Capital Management
Jersey
$4M +$3.4M +200,374 +1,803%
PHS
58
PFM Health Sciences
California
$3.88M +$3.48M +205,317 New
TAM
59
TFG Asset Management
Cayman Islands
$3.78M +$3.39M +199,994 New
HS
60
HighVista Strategies
Massachusetts
$3.51M +$3.15M +185,856 New
Point72 Asset Management
61
Point72 Asset Management
Connecticut
$3.32M -$84K -4,951 -3%
EP
62
Eversept Partners
New York
$3.04M +$2.73M +160,723 New
Swiss National Bank
63
Swiss National Bank
Switzerland
$2.99M – – –
Bank of America
64
Bank of America
North Carolina
$2.99M +$812K +47,878 +43%
SAM
65
Soviero Asset Management
New York
$2.65M -$170K -10,000 -7%
Neuberger Berman Group
66
Neuberger Berman Group
New York
$2.52M +$2.26M +133,369 New
Squarepoint
67
Squarepoint
New York
$2.37M +$1.36M +80,120 +176%
RA
68
Rosalind Advisors
Ontario, Canada
$2.36M -$10.6M -625,000 -83%
RhumbLine Advisers
69
RhumbLine Advisers
Massachusetts
$2.27M +$157K +9,225 +8%
Russell Investments Group
70
Russell Investments Group
United Kingdom
$2.26M +$1.88M +110,599 +1,248%
ECM
71
ExodusPoint Capital Management
New York
$1.98M +$1.46M +85,967 +454%
DCI
72
Data Collective IV
California
$1.9M – – –
BGM
73
Burkehill Global Management
New York
$1.89M – – –
SFCM
74
Seven Fleet Capital Management
California
$1.89M +$1.7M +99,887 New
Royal Bank of Canada
75
Royal Bank of Canada
Ontario, Canada
$1.84M +$60.5K +3,566 +4%
1 2
3
4 5

DFTX Hedge Fund Activity: Q1 2026 in Review

247 of the 8,126 institutional investors tracked by Wall St. Rank reported a position in Definium Therapeutics (DFTX) for Q1 2026, worth a combined $1.47B — up 62% from $909M a quarter earlier.

Buyers outnumbered sellers: 69 funds opened new DFTX positions and 25 closed out — a net gain of 44 holders — while 82 added to existing stakes and 52 trimmed.

The largest buyer was Fidelity Investments, adding an estimated $28M. The largest seller was Marshall Wace, cutting an estimated $30.1M.

  • 247 institutional investors held Definium Therapeutics (DFTX) as of Q1 2026, up from 208 in Q4 2025.
  • Funds reported $1.47B of Definium Therapeutics stock for Q1 2026, up 62% quarter-over-quarter.
  • 69 funds opened new Definium Therapeutics positions in Q1 2026 and 25 closed out, a net change of +44 holders.
  • The largest Definium Therapeutics buyer in Q1 2026 was Fidelity Investments, an estimated $28M added.
  • The largest Definium Therapeutics seller in Q1 2026 was Marshall Wace, an estimated $30.1M sold.

Based on aggregated 13F filings for Q1 2026.