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DFTX

Definium Therapeutics
DFTX

247 hedge funds and large institutions have $1.47B invested in Definium Therapeutics in 2026 Q1 according to their latest regulatory filings, with 69 funds opening new positions, 82 increasing their positions, 52 reducing their positions, and 25 closing their positions.

New
Increased
Maintained
Reduced
Closed

284% more call options, than puts

Call options by funds: $32.5M | Put options by funds: $8.45M

176% more first-time investments, than exits

New positions opened: 69 | Existing positions closed: 25

62% more capital invested

Capital invested by funds: $909M → $1.47B (+$566M)

58% more repeat investments, than reductions

Existing positions increased: 82 | Existing positions reduced: 52

20% more funds holding in top 10

Funds holding in top 10: 5 → 6 (+1)

19% more funds holding

Funds holding: 208 → 247 (+39)

9.4% more ownership

Funds ownership: 68.89% → 78.29% (+9.4%)

Holders
247
Holders Change
+39
Holders Change %
+18.75%
% of All Funds
3.04%
Holding in Top 10
6
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+20%
% of All Funds
0.07%
New
69
Increased
82
Reduced
52
Closed
25
Calls
$32.5M
Puts
$8.45M
Net Calls
+$24M
Net Calls Change
+$11.4M

Top Buyers

1
Fidelity Investments
Fidelity Investments
Massachusetts
+$28M
2
ACH
ArrowMark Colorado Holdings
Colorado
+$27.1M
3
DTC
Deep Track Capital
Connecticut
+$22.5M
4
Janus Henderson Group
Janus Henderson Group
United Kingdom
+$19.4M
5
Citadel Advisors
Citadel Advisors
Florida
+$19.1M

Top Sellers

1
Marshall Wace
Marshall Wace
United Kingdom
-$30.1M
2
Blackstone Inc
Blackstone Inc
New York
-$26.3M
3
TECP
Trails Edge Capital Partners
Georgia
-$14.1M
4
DCM
Driehaus Capital Management
Illinois
-$10.6M
5
RA
Rosalind Advisors
Ontario, Canada
-$10.6M
Name Holding Trade Value Shares
Change 		Change in
Stake
SL
26
Siren LLC
Connecticut
$17.4M +$2.03M +119,493 +15%
VPM
27
Vanguard Portfolio Management
Pennsylvania
$16.5M +$14.8M +872,665 New
Millennium Management
28
Millennium Management
New York
$16M -$9.1M -536,279 -39%
Charles Schwab
29
Charles Schwab
California
$15.3M +$24.9K +1,466 +0.2%
O
30
OrbiMed
New York
$15.2M -$7.17M -422,700 -34%
Northern Trust
31
Northern Trust
Illinois
$15.1M +$1.09M +64,327 +9%
Bank of New York Mellon
32
Bank of New York Mellon
New York
$14.2M +$7.71M +454,262 +152%
WP
33
Woodline Partners
California
$14.2M +$10.2M +602,222 +400%
N
34
Nuveen
North Carolina
$13.2M +$7.16M +421,676 +153%
EAM
35
Eventide Asset Management
Massachusetts
$13M +$11.6M +686,162 New
BCM
36
Boxer Capital Management
California
$11.3M – – –
VFT
37
Vanguard Fiduciary Trust
Pennsylvania
$10.9M +$9.77M +575,937 New
Ensign Peak Advisors
38
Ensign Peak Advisors
Utah
$10.3M +$4.83M +284,783 +109%
Blackstone Inc
39
Blackstone Inc
New York
$9.61M -$26.3M -1,551,137 -75%
UBS Group
40
UBS Group
Switzerland
$9.34M -$3.22M -189,825 -28%
Morgan Stanley
41
Morgan Stanley
New York
$8.29M +$1.22M +71,878 +20%
Qube Research & Technologies (QRT)
42
Qube Research & Technologies (QRT)
United Kingdom
$8.05M +$7.23M +426,055 New
Deutsche Bank
43
Deutsche Bank
Germany
$7.78M +$230K +13,565 +3%
IHAM
44
Integral Health Asset Management
New York
$7.56M +$848K +50,000 +14%
TLP
45
Tri Locum Partners
New York
$6.99M +$6.27M +369,588 New
SCM
46
Superstring Capital Management
New York
$6.64M -$1.25M -73,741 -17%
SI
47
Sofinnova Investments
California
$6.5M +$5.84M +344,166 New
PSC
48
Patient Square Capital
California
$6.26M +$5.62M +331,000 New
SC
49
Stempoint Capital
New York
$6.15M +$5.52M +325,483 New
RI
50
RTW Investments
New York
$5.67M – – –
1
2
3 4 5

DFTX Hedge Fund Activity: Q1 2026 in Review

247 of the 8,126 institutional investors tracked by Wall St. Rank reported a position in Definium Therapeutics (DFTX) for Q1 2026, worth a combined $1.47B — up 62% from $909M a quarter earlier.

Buyers outnumbered sellers: 69 funds opened new DFTX positions and 25 closed out — a net gain of 44 holders — while 82 added to existing stakes and 52 trimmed.

The largest buyer was Fidelity Investments, adding an estimated $28M. The largest seller was Marshall Wace, cutting an estimated $30.1M.

  • 247 institutional investors held Definium Therapeutics (DFTX) as of Q1 2026, up from 208 in Q4 2025.
  • Funds reported $1.47B of Definium Therapeutics stock for Q1 2026, up 62% quarter-over-quarter.
  • 69 funds opened new Definium Therapeutics positions in Q1 2026 and 25 closed out, a net change of +44 holders.
  • The largest Definium Therapeutics buyer in Q1 2026 was Fidelity Investments, an estimated $28M added.
  • The largest Definium Therapeutics seller in Q1 2026 was Marshall Wace, an estimated $30.1M sold.

Based on aggregated 13F filings for Q1 2026.