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DFTX

Definium Therapeutics
DFTX

247 hedge funds and large institutions have $1.47B invested in Definium Therapeutics in 2026 Q1 according to their latest regulatory filings, with 69 funds opening new positions, 82 increasing their positions, 52 reducing their positions, and 25 closing their positions.

New
Increased
Maintained
Reduced
Closed

284% more call options, than puts

Call options by funds: $32.5M | Put options by funds: $8.45M

176% more first-time investments, than exits

New positions opened: 69 | Existing positions closed: 25

62% more capital invested

Capital invested by funds: $909M → $1.47B (+$566M)

58% more repeat investments, than reductions

Existing positions increased: 82 | Existing positions reduced: 52

20% more funds holding in top 10

Funds holding in top 10: 5 → 6 (+1)

19% more funds holding

Funds holding: 208 → 247 (+39)

9.4% more ownership

Funds ownership: 68.89% → 78.29% (+9.4%)

Holders
247
Holders Change
+39
Holders Change %
+18.75%
% of All Funds
3.04%
Holding in Top 10
6
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+20%
% of All Funds
0.07%
New
69
Increased
82
Reduced
52
Closed
25
Calls
$32.5M
Puts
$8.45M
Net Calls
+$24M
Net Calls Change
+$11.4M

Top Buyers

1
Fidelity Investments
Fidelity Investments
Massachusetts
+$28M
2
ACH
ArrowMark Colorado Holdings
Colorado
+$27.1M
3
DTC
Deep Track Capital
Connecticut
+$22.5M
4
Janus Henderson Group
Janus Henderson Group
United Kingdom
+$19.4M
5
Citadel Advisors
Citadel Advisors
Florida
+$19.1M

Top Sellers

1
Marshall Wace
Marshall Wace
United Kingdom
-$30.1M
2
Blackstone Inc
Blackstone Inc
New York
-$26.3M
3
TECP
Trails Edge Capital Partners
Georgia
-$14.1M
4
DCM
Driehaus Capital Management
Illinois
-$10.6M
5
RA
Rosalind Advisors
Ontario, Canada
-$10.6M
Name Holding Trade Value Shares
Change 		Change in
Stake
SRL
251
Scientech Research LLC
New Jersey
– -$424K -31,699 Closed
DFCM
252
Dark Forest Capital Management
Puerto Rico
– -$411K -30,661 Closed
Mercer Global Advisors
253
Mercer Global Advisors
Colorado
– -$273K -20,392 Closed
EC
254
EntryPoint Capital
New York
– -$271K -20,219 Closed
Rafferty Asset Management
255
Rafferty Asset Management
New York
– -$253K -18,885 Closed
GAM
256
Gotham Asset Management
New York
– -$239K -17,825 Closed
CC
257
Caxton Corporation
New Jersey
– -$210K -15,688 Closed
FC
258
Fore Capital
New York
– -$201K -15,000 Closed
Wealth Enhancement Advisory Services
259
Wealth Enhancement Advisory Services
Minnesota
– -$185K -13,718 Closed
XT
260
XTX Topco
Cayman Islands
– -$147K -10,994 Closed
FHA
261
Flagship Harbor Advisors
Massachusetts
– -$117K -8,721 Closed
AB
262
Amalgamated Bank
New York
– -$40K -2,957 Closed
QT
263
Quantbot Technologies
New York
– -$22.1K -1,649 Closed
AUB
264
Atlantic Union Bankshares
Virginia
– -$6.7K -500 Closed
Daiwa Securities Group
265
Daiwa Securities Group
Japan
– -$3K -242 Closed
KBFS
266
Kohmann Bosshard Financial Services
Ohio
– -$884 -66 Closed
TCM
267
Tradewinds Capital Management
Washington
– -$710 -53 Closed
CB
268
CNB Bank
Pennsylvania
– -$134 -10 Closed
NB
269
NBT Bank
New York
– -$80 -6 Closed
NL
270
Navalign LLC
California
– -$27 -2 Closed
S
271
SignatureFD
Georgia
– -$27 -2 Closed
7 8 9 10
11

DFTX Hedge Fund Activity: Q1 2026 in Review

247 of the 8,126 institutional investors tracked by Wall St. Rank reported a position in Definium Therapeutics (DFTX) for Q1 2026, worth a combined $1.47B — up 62% from $909M a quarter earlier.

Buyers outnumbered sellers: 69 funds opened new DFTX positions and 25 closed out — a net gain of 44 holders — while 82 added to existing stakes and 52 trimmed.

The largest buyer was Fidelity Investments, adding an estimated $28M. The largest seller was Marshall Wace, cutting an estimated $30.1M.

  • 247 institutional investors held Definium Therapeutics (DFTX) as of Q1 2026, up from 208 in Q4 2025.
  • Funds reported $1.47B of Definium Therapeutics stock for Q1 2026, up 62% quarter-over-quarter.
  • 69 funds opened new Definium Therapeutics positions in Q1 2026 and 25 closed out, a net change of +44 holders.
  • The largest Definium Therapeutics buyer in Q1 2026 was Fidelity Investments, an estimated $28M added.
  • The largest Definium Therapeutics seller in Q1 2026 was Marshall Wace, an estimated $30.1M sold.

Based on aggregated 13F filings for Q1 2026.