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DFTX

Definium Therapeutics
DFTX

247 hedge funds and large institutions have $1.47B invested in Definium Therapeutics in 2026 Q1 according to their latest regulatory filings, with 69 funds opening new positions, 82 increasing their positions, 52 reducing their positions, and 25 closing their positions.

New
Increased
Maintained
Reduced
Closed

284% more call options, than puts

Call options by funds: $32.5M | Put options by funds: $8.45M

176% more first-time investments, than exits

New positions opened: 69 | Existing positions closed: 25

62% more capital invested

Capital invested by funds: $909M → $1.47B (+$566M)

58% more repeat investments, than reductions

Existing positions increased: 82 | Existing positions reduced: 52

20% more funds holding in top 10

Funds holding in top 10: 5 → 6 (+1)

19% more funds holding

Funds holding: 208 → 247 (+39)

9.4% more ownership

Funds ownership: 68.89% → 78.29% (+9.4%)

Holders
247
Holders Change
+39
Holders Change %
+18.75%
% of All Funds
3.04%
Holding in Top 10
6
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+20%
% of All Funds
0.07%
New
69
Increased
82
Reduced
52
Closed
25
Calls
$32.5M
Puts
$8.45M
Net Calls
+$24M
Net Calls Change
+$11.4M

Top Buyers

1
Fidelity Investments
Fidelity Investments
Massachusetts
+$28M
2
ACH
ArrowMark Colorado Holdings
Colorado
+$27.1M
3
DTC
Deep Track Capital
Connecticut
+$22.5M
4
Janus Henderson Group
Janus Henderson Group
United Kingdom
+$19.4M
5
Citadel Advisors
Citadel Advisors
Florida
+$19.1M

Top Sellers

1
Marshall Wace
Marshall Wace
United Kingdom
-$30.1M
2
Blackstone Inc
Blackstone Inc
New York
-$26.3M
3
TECP
Trails Edge Capital Partners
Georgia
-$14.1M
4
DCM
Driehaus Capital Management
Illinois
-$10.6M
5
RA
Rosalind Advisors
Ontario, Canada
-$10.6M
Name Holding Trade Value Shares
Change 		Change in
Stake
MF
151
Magnetar Financial
Illinois
$249K +$224K +13,178 New
MCC
152
Money Concepts Capital
Florida
$246K – – –
STA
153
Summit Trail Advisors
New York
$246K +$221K +13,000 New
FDCDDQ
154
Federation des caisses Desjardins du Quebec
Quebec, Canada
$239K +$34.6K +2,040 +19%
Stifel Financial
155
Stifel Financial
Missouri
$239K +$214K +12,626 New
CCM
156
Cinctive Capital Management
New York
$237K +$213K +12,551 New
TPWM
157
Twelve Points Wealth Management
Massachusetts
$231K +$27.2K +1,600 +15%
Bank of Montreal
158
Bank of Montreal
Ontario, Canada
$229K +$5.67K +334 +3%
DWM
159
Diversify Wealth Management
Utah
$225K +$17K +1,000 +10%
SA
160
Sanctuary Advisors
Indiana
$217K +$12.7K +749 +7%
CPIG
161
Chicago Partners Investment Group
Illinois
$215K +$158K +9,307 New
RAS
162
RPS Advisory Solutions
Kentucky
$215K +$193K +11,355 New
DTL
163
Dynamic Technology Lab
Singapore
$206K -$205K -12,084 -53%
Osaic Holdings
164
Osaic Holdings
Arizona
$200K +$543 +32 +0.3%
SG Americas Securities
165
SG Americas Securities
New York
$198K +$178K +10,493 New
SSA
166
Schonfeld Strategic Advisors
New York
$197K -$340K -20,044 -66%
Verition Fund Management
167
Verition Fund Management
Connecticut
$196K -$2.07M -121,879 -92%
Teacher Retirement System of Texas
168
Teacher Retirement System of Texas
Texas
$195K -$25.4K -1,497 -13%
Commonwealth Equity Services
169
Commonwealth Equity Services
Massachusetts
$194K -$57K -3,360 -25%
CIBC World Market
170
CIBC World Market
Ontario, Canada
$190K +$171K +10,049 New
S
171
SharpePoint
Arizona
$189K -$2.29K -135 -1%
KWMG
172
King Wealth Management Group
Florida
$189K – – –
SLAM
173
Swiss Life Asset Management
$187K +$301K +17,745 New
AIP
174
Ameritas Investment Partners
Nebraska
$144K – – –
PNC Financial Services Group
175
PNC Financial Services Group
Pennsylvania
$144K +$9.03K +532 +8%
5 6
7
8 9

DFTX Hedge Fund Activity: Q1 2026 in Review

247 of the 8,126 institutional investors tracked by Wall St. Rank reported a position in Definium Therapeutics (DFTX) for Q1 2026, worth a combined $1.47B — up 62% from $909M a quarter earlier.

Buyers outnumbered sellers: 69 funds opened new DFTX positions and 25 closed out — a net gain of 44 holders — while 82 added to existing stakes and 52 trimmed.

The largest buyer was Fidelity Investments, adding an estimated $28M. The largest seller was Marshall Wace, cutting an estimated $30.1M.

  • 247 institutional investors held Definium Therapeutics (DFTX) as of Q1 2026, up from 208 in Q4 2025.
  • Funds reported $1.47B of Definium Therapeutics stock for Q1 2026, up 62% quarter-over-quarter.
  • 69 funds opened new Definium Therapeutics positions in Q1 2026 and 25 closed out, a net change of +44 holders.
  • The largest Definium Therapeutics buyer in Q1 2026 was Fidelity Investments, an estimated $28M added.
  • The largest Definium Therapeutics seller in Q1 2026 was Marshall Wace, an estimated $30.1M sold.

Based on aggregated 13F filings for Q1 2026.