We are live on ! Find out more
DFTX

Definium Therapeutics
DFTX

247 hedge funds and large institutions have $1.47B invested in Definium Therapeutics in 2026 Q1 according to their latest regulatory filings, with 69 funds opening new positions, 82 increasing their positions, 52 reducing their positions, and 25 closing their positions.

New
Increased
Maintained
Reduced
Closed

284% more call options, than puts

Call options by funds: $32.5M | Put options by funds: $8.45M

176% more first-time investments, than exits

New positions opened: 69 | Existing positions closed: 25

62% more capital invested

Capital invested by funds: $909M → $1.47B (+$566M)

58% more repeat investments, than reductions

Existing positions increased: 82 | Existing positions reduced: 52

20% more funds holding in top 10

Funds holding in top 10: 5 → 6 (+1)

19% more funds holding

Funds holding: 208 → 247 (+39)

9.4% more ownership

Funds ownership: 68.89% → 78.29% (+9.4%)

Holders
247
Holders Change
+39
Holders Change %
+18.75%
% of All Funds
3.04%
Holding in Top 10
6
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+20%
% of All Funds
0.07%
New
69
Increased
82
Reduced
52
Closed
25
Calls
$32.5M
Puts
$8.45M
Net Calls
+$24M
Net Calls Change
+$11.4M

Top Buyers

1
Fidelity Investments
Fidelity Investments
Massachusetts
+$28M
2
ACH
ArrowMark Colorado Holdings
Colorado
+$27.1M
3
DTC
Deep Track Capital
Connecticut
+$22.5M
4
Janus Henderson Group
Janus Henderson Group
United Kingdom
+$19.4M
5
Citadel Advisors
Citadel Advisors
Florida
+$19.1M

Top Sellers

1
Marshall Wace
Marshall Wace
United Kingdom
-$30.1M
2
Blackstone Inc
Blackstone Inc
New York
-$26.3M
3
TECP
Trails Edge Capital Partners
Georgia
-$14.1M
4
DCM
Driehaus Capital Management
Illinois
-$10.6M
5
RA
Rosalind Advisors
Ontario, Canada
-$10.6M
Name Holding Trade Value Shares
Change 		Change in
Stake
SS
226
SBI Securities
Japan
$1.85K +$119 +7 +8%
MASM
227
MH & Associates Securities Management
California
$1.25K – – –
AWM
228
Activest Wealth Management
Florida
$1.25K – – –
LI
229
Louisbourg Investments
New Brunswick, Canada
$983 +$882 +52 New
Optiver Holding
230
Optiver Holding
Netherlands
$926 -$1.26K -74 -60%
SS
231
Sunbelt Securities
Texas
$832 – – –
PMFA
232
Plante Moran Financial Advisors
Michigan
$680 – – –
ACM
233
Anfield Capital Management
California
$680 +$611 +36 New
FGAM
234
Financial Gravity Asset Management
Texas
$662 – – –
RWM
235
RMG Wealth Management
Wisconsin
$642 +$509 +30 New
CAM
236
Chesapeake Asset Management
New York
$623 – – –
BWM
237
Benson Wealth Management
Tennessee
$567 +$509 +30 New
RF
238
Robbins Farley
New Hampshire
$530 – – –
VNT
239
Vanguard National Trust
Pennsylvania
$510 +$458 +27 New
RIAS
240
Rachor Investment Advisory Services
Michigan
$473 – – –
PWPS
241
Pinnacle Wealth Planning Services
Ohio
$472 – – –
EP
242
Essential Partners
California
$397 – – –
NA
243
NewEdge Advisors
Louisiana
$125 -$2.26K -133 -95%
CA
244
CoreCap Advisors
Michigan
$95 – – –
KFAS
245
Keating Financial Advisory Services
Kansas
$19 -$102 -6 -86%
HNB
246
Huntington National Bank
Ohio
$1 – – –
VPC
247
Vestal Point Capital
New York
– -$8.53M -637,000 Closed
Universal-Beteiligungs- und Servicegesellschaft
248
Universal-Beteiligungs- und Servicegesellschaft
Germany
– -$3.73M -278,720 Closed
Two Sigma Advisers
249
Two Sigma Advisers
New York
– -$874K -65,281 Closed
California State Teachers Retirement System (CalSTRS)
250
California State Teachers Retirement System (CalSTRS)
California
– -$782K -58,383 Closed
7 8 9
10
11

DFTX Hedge Fund Activity: Q1 2026 in Review

247 of the 8,126 institutional investors tracked by Wall St. Rank reported a position in Definium Therapeutics (DFTX) for Q1 2026, worth a combined $1.47B — up 62% from $909M a quarter earlier.

Buyers outnumbered sellers: 69 funds opened new DFTX positions and 25 closed out — a net gain of 44 holders — while 82 added to existing stakes and 52 trimmed.

The largest buyer was Fidelity Investments, adding an estimated $28M. The largest seller was Marshall Wace, cutting an estimated $30.1M.

  • 247 institutional investors held Definium Therapeutics (DFTX) as of Q1 2026, up from 208 in Q4 2025.
  • Funds reported $1.47B of Definium Therapeutics stock for Q1 2026, up 62% quarter-over-quarter.
  • 69 funds opened new Definium Therapeutics positions in Q1 2026 and 25 closed out, a net change of +44 holders.
  • The largest Definium Therapeutics buyer in Q1 2026 was Fidelity Investments, an estimated $28M added.
  • The largest Definium Therapeutics seller in Q1 2026 was Marshall Wace, an estimated $30.1M sold.

Based on aggregated 13F filings for Q1 2026.