|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$50.5M
|
-$4M
|
-195,031
|
-5%
|
|
|
2
|
Vivo Capital
Palo Alto,
California
|
$48.8M
|
+$68.1M
|
+3,320,801
|
New
|
|
|
3
|
Perceptive Advisors
New York
|
$38M
|
–
|
–
|
–
|
|
|
4
|
|
$30M
|
–
|
–
|
–
|
|
|
5
|
RA Capital Management
Boston,
Massachusetts
|
$28.8M
|
+$1.76M
|
+86,000
|
+5%
|
|
|
6
|
5AM Venture Management
San Francisco,
California
|
$27.4M
|
-$10.2M
|
-500,000
|
-21%
|
|
|
7
|
Eventide Asset Management
Boston,
Massachusetts
|
$13.9M
|
–
|
–
|
–
|
|
|
8
|
|
$10.6M
|
-$200K
|
-9,752
|
-1%
|
|
|
9
|
Vanguard Group
Malvern,
Pennsylvania
|
$7.47M
|
+$86.4K
|
+4,216
|
+0.8%
|
|
|
10
|
Janus Henderson Group
London,
|
$7.23M
|
+$57.8K
|
+2,819
|
+0.6%
|
|
|
11
|
Opaleye Management
Boston,
Massachusetts
|
$5.42M
|
+$2.1M
|
+102,650
|
+39%
|
|
|
12
|
EcoR1 Capital
San Francisco,
California
|
$5.14M
|
+$7.17M
|
+350,000
|
New
|
|
|
13
|
Burrage Capital Management
Boston,
Massachusetts
|
$4.02M
|
+$1.57M
|
+76,546
|
+37%
|
|
|
14
|
State Street
Boston,
Massachusetts
|
$3.3M
|
-$43.2K
|
-2,107
|
-0.9%
|
|
|
15
|
Polar Capital
London,
United Kingdom
|
$2.94M
|
–
|
–
|
–
|
|
|
16
|
Victory Capital Management
San Antonio,
Texas
|
$2.71M
|
-$215K
|
-10,514
|
-5%
|
|
|
17
|
Baker Bros. Advisors
New York
|
$2.57M
|
–
|
–
|
–
|
|
|
18
|
Novo Holdings A/S
Hellerup,
Denmark
|
$2.42M
|
+$603K
|
+29,444
|
+22%
|
|
|
19
|
Northern Trust
Chicago,
Illinois
|
$2.39M
|
+$285K
|
+13,903
|
+9%
|
|
|
20
|
New Leaf Venture Partners
New York
|
$2.07M
|
–
|
–
|
–
|
|
|
21
|
Geode Capital Management
Boston,
Massachusetts
|
$1.97M
|
+$115K
|
+5,610
|
+4%
|
|
|
22
|
Charles Schwab
San Francisco,
California
|
$776K
|
-$4.61K
|
-225
|
-0.4%
|
|
|
23
|
ALPS Advisors
Denver,
Colorado
|
$647K
|
-$105K
|
-5,132
|
-10%
|
|
|
24
|
Bank of New York Mellon
New York
|
$529K
|
+$3.79K
|
+185
|
+0.5%
|
|
|
25
|
Citadel Advisors
Miami,
Florida
|
$526K
|
+$160K
|
+7,809
|
+28%
|
|
