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Amylyx Pharmaceuticals
AMLX

171 hedge funds and large institutions have $1.59B invested in Amylyx Pharmaceuticals in 2026 Q1 according to their latest regulatory filings, with 29 funds opening new positions, 62 increasing their positions, 53 reducing their positions, and 36 closing their positions.

New
Increased
Maintained
Reduced
Closed

503% more call options, than puts

Call options by funds: $9.02M | Put options by funds: $1.5M

17% more repeat investments, than reductions

Existing positions increased: 62 | Existing positions reduced: 53

17% more capital invested

Capital invested by funds: $1.36B → $1.59B (+$230M)

1.02% more ownership

Funds ownership: 102.24% → 103.27% (+1%)

4% less funds holding

Funds holding: 179 → 171 (-8)

17% less funds holding in top 10

Funds holding in top 10: 6 → 5 (-1)

19% less first-time investments, than exits

New positions opened: 29 | Existing positions closed: 36

Holders
171
Holders Change
-8
Holders Change %
-4.47%
% of All Funds
2.1%
Holding in Top 10
5
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-16.67%
% of All Funds
0.06%
New
29
Increased
62
Reduced
53
Closed
36
Calls
$9.02M
Puts
$1.5M
Net Calls
+$7.52M
Net Calls Change
+$2.34M

Top Buyers

1
SL
Siren LLC
Connecticut
+$17.3M
2
Franklin Resources
Franklin Resources
California
+$14.9M
3
Adage Capital Partners
Adage Capital Partners
Massachusetts
+$11M
4
Barclays
Barclays
United Kingdom
+$9.52M
5
JAM
Jupiter Asset Management
United Kingdom
+$8.12M

Top Sellers

1
SI
Sofinnova Investments
California
-$6.37M
2
SCM
Silverarc Capital Management
Massachusetts
-$6.12M
3
Ameriprise
Ameriprise
Minnesota
-$6.07M
4
PSC
Patient Square Capital
California
-$4.23M
5
NCM
Nantahala Capital Management
Connecticut
-$4.22M
Name Holding Trade Value Shares
Change 		Change in
Stake
Jane Street
176
Jane Street
New York
– -$3.7M -263,235 Closed
Acadian Asset Management
177
Acadian Asset Management
Massachusetts
– -$3.07M -254,328 Closed
Renaissance Technologies
178
Renaissance Technologies
New York
– -$2.33M -192,500 Closed
XT
179
XTX Topco
Cayman Islands
– -$2.29M -189,673 Closed
Voloridge Investment Management
180
Voloridge Investment Management
Florida
– -$1.85M -153,363 Closed
AI
181
Atom Investors
Texas
– -$1.68M -139,422 Closed
Bank of Montreal
182
Bank of Montreal
Ontario, Canada
– -$1.67M -138,525 Closed
KCM
183
Kennondale Capital Management
Virginia
– -$645K -53,423 Closed
TI
184
Trexquant Investment
Connecticut
– -$581K -48,112 Closed
Millennium Management
185
Millennium Management
New York
– -$561K -46,455 Closed
Mariner
186
Mariner
Kansas
– -$560K -46,342 Closed
GCP
187
GSA Capital Partners
United Kingdom
– -$444K -36,758 Closed
FRM
188
Fox Run Management
Connecticut
– -$428K -35,409 Closed
PAP
189
Persistent Asset Partners
Hong Kong
– -$376K -31,147 Closed
ACM
190
Aquatic Capital Management
Illinois
– -$294K -24,352 Closed
SG Americas Securities
191
SG Americas Securities
New York
– -$252K -20,846 Closed
EGM
192
Engineers Gate Manager
New York
– -$222K -18,358 Closed
Rafferty Asset Management
193
Rafferty Asset Management
New York
– -$213K -17,673 Closed
QC
194
Quadrature Capital
United Kingdom
– -$187K -15,465 Closed
Teacher Retirement System of Texas
195
Teacher Retirement System of Texas
Texas
– -$147K -12,174 Closed
EC
196
EntryPoint Capital
New York
– -$127K -10,487 Closed
A
197
AlphaQuest
New York
– -$86.9K -7,195 Closed
T. Rowe Price Investment Management
198
T. Rowe Price Investment Management
Maryland
– -$55K -4,517 Closed
Simplex Trading
199
Simplex Trading
Illinois
– -$52.4K -3,727 Closed
Walleye Trading
200
Walleye Trading
New York
– -$34.1K -2,825 Closed
5 6 7
8
9

AMLX Hedge Fund Activity: Q1 2026 in Review

171 of the 8,126 institutional investors tracked by Wall St. Rank reported a position in Amylyx Pharmaceuticals (AMLX) for Q1 2026, worth a combined $1.59B — up 17% from $1.36B a quarter earlier.

Sellers outnumbered buyers: 36 funds closed out of AMLX and 29 opened new positions — a net loss of 7 holders — while 53 trimmed existing stakes and 62 added.

The largest buyer was Siren LLC, opening a new position worth an estimated $17.3M. The largest seller was Sofinnova Investments, exiting entirely with an estimated $6.37M sold.

  • 171 institutional investors held Amylyx Pharmaceuticals (AMLX) as of Q1 2026, down from 179 in Q4 2025.
  • Funds reported $1.59B of Amylyx Pharmaceuticals stock for Q1 2026, up 17% quarter-over-quarter.
  • 29 funds opened new Amylyx Pharmaceuticals positions in Q1 2026 and 36 closed out, a net change of -7 holders.
  • The largest Amylyx Pharmaceuticals buyer in Q1 2026 was Siren LLC, an estimated $17.3M added.
  • The largest Amylyx Pharmaceuticals seller in Q1 2026 was Sofinnova Investments, an estimated $6.37M sold.

Based on aggregated 13F filings for Q1 2026.