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Amylyx Pharmaceuticals
AMLX

Overview Fund Activity

134 hedge funds and large institutions have $262M invested in Amylyx Pharmaceuticals in 2025 Q1 according to their latest regulatory filings, with 32 funds opening new positions, 50 increasing their positions, 31 reducing their positions, and 16 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
134
Holders Change
+14
Holders Change %
+11.67%
% of All Funds
1.82%
Holding in Top 10
1
Holding in Top 10 Change
+1
Holding in Top 10 Change %
%
% of All Funds
0.01%
New
32
Increased
50
Reduced
31
Closed
16
Calls
$524K
Puts
$606K
Net Calls
-$82K
Net Calls Change
+$497K

Top Buyers

1
Adage Capital Partners
Adage Capital Partners
Massachusetts
+$20.2M
2
Millennium Management
Millennium Management
New York
+$8.81M
3
GPP
Great Point Partners
Connecticut
+$6.41M
4
WP
Woodline Partners
California
+$5.7M
5
SVCM
Saturn V Capital Management
Texas
+$5.44M

Top Sellers

1
Bank of America
Bank of America
North Carolina
-$5.78M
2
Jane Street
Jane Street
New York
-$1.54M
3
CSS
Cubist Systematic Strategies
Connecticut
-$1.38M
4
Acadian Asset Management
Acadian Asset Management
Massachusetts
-$1.31M
5
Walleye Capital
Walleye Capital
New York
-$948K
Name Holding Trade Value Shares
Change 		Shares
Change %
Nisa Investment Advisors
126
Nisa Investment Advisors
Missouri
$1.01K -$743 -210 -42%
Daiwa Securities Group
127
Daiwa Securities Group
Japan
$1K – – –
PWA
128
Physician Wealth Advisors
Utah
$970 +$970 +274 New
CCM
129
Coldstream Capital Management
Washington
$843 +$843 +238 New
HI
130
Harbour Investments
Wisconsin
$319 – – –
SIC
131
Salem Investment Counselors
North Carolina
$195 – – –
PNC Financial Services Group
132
PNC Financial Services Group
Pennsylvania
$188 – – –
EWA
133
EverSource Wealth Advisors
Alabama
$89 – – –
SS
134
SBI Securities
Japan
$4 – – –
IC
135
Ikarian Capital
Texas
– -$760K -201,187 Closed
AQR Capital Management
136
AQR Capital Management
Connecticut
– -$712K -188,386 Closed
Mackenzie Financial
137
Mackenzie Financial
Ontario, Canada
– -$421K -111,310 Closed
JF
138
Jump Financial
Illinois
– -$394K -104,342 Closed
BFM
139
Boothbay Fund Management
New York
– -$304K -80,543 Closed
LCM
140
Landscape Capital Management
New Jersey
– -$188K -49,661 Closed
AGM
141
Alpine Global Management
New York
– -$90.8K -24,034 Closed
WS
142
Wedbush Securities
California
– -$75K -19,914 Closed
YIH
143
Y-Intercept (HK)
Hong Kong
– -$56K -14,809 Closed
RL
144
RPO LLC
Connecticut
– -$45.9K -12,136 Closed
Bank of Nova Scotia
145
Bank of Nova Scotia
Ontario, Canada
– -$44.9K -11,884 Closed
FRM
146
Fox Run Management
Connecticut
– -$44.6K -11,788 Closed
VA
147
Vident Advisory
Georgia
– -$41.1K -10,862 Closed
Walleye Trading
148
Walleye Trading
New York
– -$10K -2,649 Closed
AAP
149
Arax Advisory Partners
Colorado
– -$8.29K -2,193 Closed
Osaic Holdings
150
Osaic Holdings
Arizona
– -$2.41K -638 Closed
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