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Amylyx Pharmaceuticals
AMLX

Overview Fund Activity

134 hedge funds and large institutions have $262M invested in Amylyx Pharmaceuticals in 2025 Q1 according to their latest regulatory filings, with 32 funds opening new positions, 50 increasing their positions, 31 reducing their positions, and 16 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
134
Holders Change
+14
Holders Change %
+11.67%
% of All Funds
1.82%
Holding in Top 10
1
Holding in Top 10 Change
+1
Holding in Top 10 Change %
%
% of All Funds
0.01%
New
32
Increased
50
Reduced
31
Closed
16
Calls
$524K
Puts
$606K
Net Calls
-$82K
Net Calls Change
+$497K

Top Buyers

1
Adage Capital Partners
Adage Capital Partners
Massachusetts
+$20.2M
2
Millennium Management
Millennium Management
New York
+$8.81M
3
GPP
Great Point Partners
Connecticut
+$6.41M
4
WP
Woodline Partners
California
+$5.7M
5
SVCM
Saturn V Capital Management
Texas
+$5.44M

Top Sellers

1
Bank of America
Bank of America
North Carolina
-$5.78M
2
Jane Street
Jane Street
New York
-$1.54M
3
CSS
Cubist Systematic Strategies
Connecticut
-$1.38M
4
Acadian Asset Management
Acadian Asset Management
Massachusetts
-$1.31M
5
Walleye Capital
Walleye Capital
New York
-$948K
Name Holding Trade Value Shares
Change 		Shares
Change %
RS
101
R Squared
Hong Kong
$45.1K +$22.5K +6,366 +100%
QC
102
Quadrature Capital
United Kingdom
$45K +$45K +12,744 New
Royal Bank of Canada
103
Royal Bank of Canada
Ontario, Canada
$42K -$85 -24 -0.2%
BHCM
104
Brevan Howard Capital Management
Jersey
$40.1K +$40.1K +11,330 New
CM
105
Capula Management
Cayman Islands
$38.9K +$38.9K +10,980 New
EC
106
EntryPoint Capital
New York
$37.5K -$11.8K -3,322 -24%
Hudson Bay Capital Management
107
Hudson Bay Capital Management
Connecticut
$36.6K +$36.6K +10,340 New
VFA
108
Valeo Financial Advisors
Indiana
$35.4K +$35.4K +10,000 New
TRCT
109
Tower Research Capital (TRC)
New York
$24.1K -$139K -39,184 -85%
Russell Investments Group
110
Russell Investments Group
United Kingdom
$23.7K +$5.77K +1,631 +32%
PD
111
Point72 (DIFC)
United Arab Emirates
$17.9K +$889 +251 +5%
US Bancorp
112
US Bancorp
Minnesota
$14.2K – – –
Simplex Trading
113
Simplex Trading
Illinois
$14K -$45.9K -13,657 -77%
Zurich Cantonal Bank
114
Zurich Cantonal Bank
Switzerland
$11.2K +$11.2K +3,152 New
Mirae Asset Global Investments
115
Mirae Asset Global Investments
South Korea
$10.7K +$2.36K +646 +28%
LWCFA
116
Loring Wolcott & Coolidge Fiduciary Advisors
Massachusetts
$9.12K – – –
AAM
117
Advisors Asset Management
Colorado
$9.11K -$4.7K -1,329 -34%
CIAM
118
Caitong International Asset Management
Hong Kong
$7.89K +$7.89K +2,229 New
SPIA
119
Steward Partners Investment Advisory
New York
$7.08K – – –
GFM
120
GF Fund Management
China
$6.02K +$924 +261 +18%
BNP Paribas Financial Markets
121
BNP Paribas Financial Markets
France
$4.83K +$758 +214 +19%
Carson Wealth (CWM LLC)
122
Carson Wealth (CWM LLC)
Nebraska
$3K – – –
DF
123
Dunhill Financial
United Kingdom
$2.12K – – –
NC
124
North Capital
Utah
$1.77K +$1.77K +500 New
Wells Fargo
125
Wells Fargo
California
$1.06K – – –
2 3 4
5
6