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Amylyx Pharmaceuticals
AMLX

Overview Fund Activity

134 hedge funds and large institutions have $262M invested in Amylyx Pharmaceuticals in 2025 Q1 according to their latest regulatory filings, with 32 funds opening new positions, 50 increasing their positions, 31 reducing their positions, and 16 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
134
Holders Change
+14
Holders Change %
+11.67%
% of All Funds
1.82%
Holding in Top 10
1
Holding in Top 10 Change
+1
Holding in Top 10 Change %
%
% of All Funds
0.01%
New
32
Increased
50
Reduced
31
Closed
16
Calls
$524K
Puts
$606K
Net Calls
-$82K
Net Calls Change
+$497K

Top Buyers

1
Adage Capital Partners
Adage Capital Partners
Massachusetts
+$20.2M
2
Millennium Management
Millennium Management
New York
+$8.81M
3
GPP
Great Point Partners
Connecticut
+$6.41M
4
WP
Woodline Partners
California
+$5.7M
5
SVCM
Saturn V Capital Management
Texas
+$5.44M

Top Sellers

1
Bank of America
Bank of America
North Carolina
-$5.78M
2
Jane Street
Jane Street
New York
-$1.54M
3
CSS
Cubist Systematic Strategies
Connecticut
-$1.38M
4
Acadian Asset Management
Acadian Asset Management
Massachusetts
-$1.31M
5
Walleye Capital
Walleye Capital
New York
-$948K
Name Holding Trade Value Shares
Change 		Shares
Change %
LP
76
LMR Partners
United Kingdom
$153K +$153K +43,228 New
PAS
77
Point72 Asia (Singapore)
Singapore
$153K -$105K -29,663 -41%
QC
78
Quantessence Capital
New York
$142K +$142K +40,134 New
XT
79
XTX Topco
Cayman Islands
$140K -$49K -13,834 -26%
GC
80
Guggenheim Capital
Illinois
$134K +$6.83K +1,928 +5%
Tudor Investment Corp
81
Tudor Investment Corp
Connecticut
$118K -$917 -259 -0.8%
CC
82
Centiva Capital
New York
$99.9K -$19.9K -5,609 -17%
CGIM
83
Cannon Global Investment Management
Florida
$90.3K +$90.3K +25,500 New
SG Americas Securities
84
SG Americas Securities
New York
$89K +$32.7K +9,252 +58%
Verition Fund Management
85
Verition Fund Management
Connecticut
$85K +$85K +24,013 New
GCP
86
GSA Capital Partners
United Kingdom
$82K +$44.2K +12,446 +117%
PP
87
Paloma Partners
Connecticut
$78.7K +$78.7K +22,242 New
VPIM
88
Vanguard Personalized Indexing Management
California
$77K +$14.3K +4,032 +23%
PCM
89
Parsons Capital Management
Rhode Island
$76.6K – – –
PPWP
90
Premier Path Wealth Partners
New Jersey
$71.7K +$71.7K +20,265 New
Brown Advisory
91
Brown Advisory
Maryland
$70.6K – – –
CUAMC
92
China Universal Asset Management Company
China
$60.8K +$9.39K +2,653 +18%
Capstone Investment Advisors
93
Capstone Investment Advisors
New York
$57.2K +$57.2K +16,150 New
SOW
94
State of Wyoming
Wyoming
$56.4K -$556 -157 -1%
Prudential Financial
95
Prudential Financial
New Jersey
$53.8K -$14.9K -4,200 -22%
CFM
96
Catalyst Funds Management
Australia
$52.8K +$52.8K +14,905 New
HSBC Holdings
97
HSBC Holdings
United Kingdom
$51.4K +$10.2K +2,853 +25%
EGM
98
Engineers Gate Manager
New York
$47.4K -$15.1K -4,255 -24%
TSS
99
Two Sigma Securities
New York
$47.1K +$47.1K +13,301 New
Ameriprise
100
Ameriprise
Minnesota
$45.3K -$133K -37,623 -75%
2 3
4
5 6