Steven Cohen’s Upstream Bio Inc UPB Stock Holding History

Steven Cohen’s Portfolio UPB Stock Details UPB Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q2	–	Sell	-11,500	Closed	-$104K	–	4700
2026 Q1	$104K	Buy	11,500 +1,800	+19%	+$32.4K	﹤0.01%	3606
2025 Q4	$263K	Buy	+9,700	New	+$241K	﹤0.01%	3528

Other funds holding UPB

Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return

OrbiMed New York $5.4B AUM 163.13% 1-Year Est. Return

Norges Bank Oslo, Norway $1T AUM

BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return

Decheng Capital Menlo Park, California $732M AUM 275.56% 1-Year Est. Return

Enavate Sciences Menlo Park, California $345M AUM 134.64% 1-Year Est. Return

Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM

Millennium Management New York $276B AUM 44.8% 1-Year Est. Return

D.E. Shaw & Co New York $210B AUM 57.28% 1-Year Est. Return

JP Morgan Chase New York $1.81T AUM 41.13% 1-Year Est. Return

Steven Cohen's UPB Position: Q2 2026 in Review

Steven Cohen increased its Upstream Bio Inc (UPB) stake by 154% in Q2 2026, buying an estimated $2.3M and bringing the position to 453,011 shares worth $3.13M. The position accounts for ﹤0.01% of the portfolio, ranked #2096.

Steven Cohen first reported a position in UPB in Q1 2026 and has held it in 2 quarters since. 149 funds tracked by Wall St. Rank hold UPB as of Q2 2026.

Steven Cohen held 453,011 shares of Upstream Bio Inc worth $3.13M as of Q2 2026.
Steven Cohen bought 274,843 Upstream Bio Inc shares in Q2 2026, an estimated $2.3M.
Upstream Bio Inc made up ﹤0.01% of Steven Cohen's portfolio in Q2 2026, its #2096 holding.
Steven Cohen first reported a position in Upstream Bio Inc in Q1 2026 and has held it in 2 quarters since.
149 funds tracked by Wall St. Rank held Upstream Bio Inc as of Q2 2026.

Based on Point72 Asset Management's 13F filing for Q2 2026, filed 14 Aug 2026.