Siren LLC Portfolio holdings

AUM $1.93B

1-Year Est. Return 118.08%

2025 Q2 2025 Q1 2024 Q4 2024 Q3

This Quarter Est. Return

1 Year Est. Return

+118.08%

3 Year Est. Return

5 Year Est. Return

10 Year Est. Return

AUM

$1.77B

AUM Growth

-$491M (-22%)

Cap. Flow

Cap. Flow % of AUM

Top 10 Holdings % Top 10 Hldgs %

Holding

140

New

Increased

Reduced

Closed

Top Buys

1		+$64.3M
2		+$53.2M
3		+$26.8M
4	Edgewise Therapeutics EWTX	+$21.2M
5	Rhythm Pharmaceuticals RYTM	+$14.7M

Top Sells

1		+$70.8M
2		+$49.8M
3		+$42.2M
4	Madrigal Pharmaceuticals MDGL	+$38.9M
5	Cytokinetics CYTK	+$18.9M

Sector Composition

1	Healthcare	89.75%
2	Technology	5.2%
3	Communication Services	2.41%
4	Consumer Discretionary	1.21%
5	Real Estate	0.81%

Communication Services

Advertising Agencies

Broadcasting

Electronic Gaming & Multimedia

Entertainment

Internet Content & Information

Publishing

Telecom Services

Consumer Discretionary

Apparel Manufacturing

Apparel Retail

Auto Manufacturers

Auto Parts

Auto & Truck Dealerships

Department Stores

Footwear & Accessories

Furnishings, Fixtures & Appliances

Gambling

Home Improvement Retail

Internet Retail

Leisure

Lodging

Luxury Goods

Packaging & Containers

Personal Services

Recreational Vehicles

Residential Construction

Resorts & Casinos

Restaurants

Specialty Retail

Textile Manufacturing

Travel Services

Consumer Staples

Beverages - Brewers

Beverages - Non-Alcoholic

Beverages - Wineries & Distilleries

Confectioners

Discount Stores

Education & Training Services

Farm Products

Food Distribution

Grocery Stores

Household & Personal Products

Packaged Foods

Tobacco

Energy

Oil & Gas Drilling

Oil & Gas Equipment & Services

Oil & Gas Exploration & Production

Oil & Gas Integrated

Oil & Gas Midstream

Oil & Gas Refining & Marketing

Thermal Coal

Uranium

Financials

Asset Management

Banks - Diversified

Banks - Regional

Capital Markets

Credit Services

Diversified Insurance

Financial Conglomerates

Financial Data & Stock Exchanges

Insurance Brokers

Life Insurance

Mortgage Finance

Property & Casualty Insurance

Reinsurance

Shell Companies

Specialty - Insurance

Healthcare

Biotechnology

Diagnostics & Research

Drug Manufacturers - General

Drug Manufacturers - Specialty & Generic

Healthcare Plans

Health Information Services

Medical Care Facilities

Medical Devices

Medical Distribution

Medical Instruments & Supplies

Pharmaceutical Retailers

Industrials

Aerospace & Defense

Airlines

Airports & Air Services

Building Products & Equipment

Business Equipment & Supplies

Conglomerates

Consulting Services

Electrical Equipment & Parts

Engineering & Construction

Farm & Heavy Construction Machinery

Industrial Distribution

Infrastructure Operations

Integrated Freight & Logistics

Marine Shipping

Metal Fabrication

Pollution & Treatment Controls

Railroads

Rental & Leasing Services

Security & Protection Services

Specialty Business Services

Specialty Industrial Machinery

Staffing & Employment Services

Tools & Accessories

Trucking

Waste Management

Materials

Agricultural Inputs

Aluminum

Building Materials

Chemicals

Coking Coal

Copper

Gold

Lumber & Wood Production

Other Industrial Metals & Mining

Other Precious Metals & Mining

Paper & Paper Products

Silver

Specialty Chemicals

Steel

Real Estate

Diversified REIT

Healthcare Facilities REIT

Hotel & Motel REIT

Industrial REIT

Mortgage REIT

Office REIT

Real Estate Development

Real Estate Diversified

Real Estate Services

Residential REIT

Retail REIT

Specialty REIT

Technology

Communication Equipment

Computer Hardware

Consumer Electronics

Electronic Components

Electronics & Computer Distribution

Information Technology Services

Scientific & Technical Instruments

Semiconductor Equipment & Materials

Semiconductors

Software - Application

Software - Infrastructure

Solar

Utilities

Diversified Utilities

Electric Utilities

Gas Utilities

Independent Power Producers

Renewable Electricity

Water Utilities

#	Name	Market Value	Portfolio Weight	Shares or Principal
76	76 Reddit RDDT $39.9B	$2.47M	0.14%	+23,500
77	77 LPL Financial LPLA $27.4B	$2.45M	0.14%	+7,500
78	78 Sagimet Biosciences SGMT $268M	$2.36M	0.13%	724,771
79	79 Eledon Pharmaceuticals ELDN $238M	$2.34M	0.13%	+690,170
80	80 Tesla TSLA $1.53T	$2.33M	0.13%	+9,000
81	KLRS 81 Kalaris Therapeutics KLRS $93.5M	$2.27M	0.13%	282,586 -4,247
82	82 Marvell Technology MRVL $76.3B	$2.27M	0.13%	36,808 +31,808
83	83 Qualcomm QCOM $195B	$2.15M	0.12%	14,000 -1,000
84	84 KE Holdings BEKE $21B	$2.11M	0.12%	105,000 +45,000
85	85 Lexeo Therapeutics LXEO $725M	$2.09M	0.12%	603,435
86	86 ProQR Therapeutics PRQR $300M	$2.06M	0.12%	1,552,183 -22,817
87	87 Palo Alto Networks PANW $150B	$1.96M	0.11%	11,500 +5,500
88	SAIL 88 SailPoint Inc SAIL $12.5B	$1.78M	0.1%	+95,000
89	89 Black Diamond Therapeutics BDTX $221M	$1.62M	0.09%	1,046,517
90	SARO 90 StandardAero Inc SARO $9.54B	$1.51M	0.09%	+56,855
91	BIOA 91 BioAge Labs BIOA $283M	$1.44M	0.08%	382,406 -5,594
92	92 Tourmaline Bio TRML $1.23B	$1.39M	0.08%	91,426
93	93 Workiva WK $4.98B	$1.33M	0.07%	17,500 +7,500
94	94 BILL Holdings BILL $5.12B	$1.31M	0.07%	+28,500
95	95 PayPal PYPL $68.7B	$1.3M	0.07%	20,000 +5,000
96	96 Generation Bio GBIO $39M	$1.2M	0.07%	296,893 -1,380
97	97 Semrush SEMR $1.16B	$1.17M	0.07%	125,000 +90,000
98	98 Pegasystems PEGA $11.1B	$1.15M	0.06%	+33,000
99	99 MongoDB MDB $27.4B	$965K	0.05%	+5,500
100	100 Nike NKE $99.7B	$952K	0.05%	+15,000