We are live on ! Find out more
SL

Siren LLC Portfolio holdings

AUM $3.61B
1-Year Est. Return 203.3%
This Fund
S&P 500
This Quarter Est. Return
-13.7%
1 Year Est. Return
+203.3%
3 Year Est. Return
–
5 Year Est. Return
–
10 Year Est. Return
–
AUM
$1.77B
AUM Growth
-$491M
Cap. Flow
+$34.8M
Cap. Flow %
1.96%
Top 10 Hldgs %
50.37%
Holding
141
New
23
Increased
28
Reduced
41
Closed
25

Top Buys

Rank Stock Value
1
BPMC
Blueprint Medicines
BPMC
+$70.8M
2
IRON icon
Disc Medicine
IRON
+$59.6M
3
EWTX icon
Edgewise Therapeutics
EWTX
+$25.2M
4
DYN icon
Dyne Therapeutics
DYN
+$19.6M
5
SLNO
Soleno Therapeutics
SLNO
+$18.3M

Top Sells

Rank Stock Value
1
ARGX icon
argenx
ARGX
+$70.8M
2
SWTX
SpringWorks Therapeutics
SWTX
+$49.8M
3
MDGL icon
Madrigal Pharmaceuticals
MDGL
+$38.9M
4
ONC
BeOne Medicines Ltd
ONC
+$36.2M
5
CYTK icon
Cytokinetics
CYTK
+$18.9M

Sector Composition

Rank Sector Weight
1 Healthcare 89.75%
2 Technology 5.2%
3 Communication Services 2.41%
4 Consumer Discretionary 1.21%
5 Real Estate 0.81%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
RDDT icon
76
Reddit
RDDT
$31.1B
$2.47M 0.14%
+23,500
New +$3.88M
LPLA icon
77
LPL Financial
LPLA
$28.6B
$2.45M 0.14%
+7,500
New +$2.61M
SGMT icon
78
Sagimet Biosciences
SGMT
$559M
$2.36M 0.13%
724,771
– –
ELDN icon
79
Eledon Pharmaceuticals
ELDN
$285M
$2.34M 0.13%
+690,170
New +$2.84M
TSLA icon
80
Tesla
TSLA
$1.3T
$2.33M 0.13%
+9,000
New +$3M
KLRS
81
Kalaris Therapeutics
KLRS
$96.8M
$2.27M 0.13%
282,586
-4,247
-1% -$41.6K
MRVL icon
82
Marvell Technology
MRVL
$196B
$2.27M 0.13%
36,808
+31,808
+636% +$3.09M
QCOM icon
83
Qualcomm
QCOM
$176B
$2.15M 0.12%
14,000
-1,000
-7% -$163K
BEKE icon
84
KE Holdings
BEKE
$18.8B
$2.11M 0.12%
105,000
+45,000
+75% +$892K
LXEO icon
85
Lexeo Therapeutics
LXEO
$378M
$2.09M 0.12%
603,435
– –
PRQR icon
86
ProQR Therapeutics
PRQR
$265M
$2.06M 0.12%
1,552,183
-22,817
-1% -$48.6K
PANW icon
87
Palo Alto Networks
PANW
$297B
$1.96M 0.11%
11,500
+5,500
+92% +$1.02M
SAIL
88
SailPoint Inc
SAIL
$10.6B
$1.78M 0.1%
+95,000
New +$2.07M
BDTX icon
89
Black Diamond Therapeutics
BDTX
$112M
$1.62M 0.09%
1,046,517
– –
SARO
90
StandardAero Inc
SARO
$9.7B
$1.51M 0.09%
+56,855
New +$1.52M
BIOA
91
BioAge Labs
BIOA
$538M
$1.44M 0.08%
382,406
-5,594
-1% -$25.9K
TRML
92
DELISTED
Tourmaline Bio
TRML
$1.39M 0.08%
91,426
– –
WK icon
93
Workiva
WK
$3.54B
$1.33M 0.07%
17,500
+7,500
+75% +$708K
BILL icon
94
BILL Holdings
BILL
$4.78B
$1.31M 0.07%
+28,500
New +$1.92M
PYPL icon
95
PayPal
PYPL
$50.5B
$1.3M 0.07%
20,000
+5,000
+33% +$389K
GBIO
96
DELISTED
Generation Bio
GBIO
$1.2M 0.07%
296,893
-1,380
-0.5% -$9.7K
SEMR
97
DELISTED
Semrush
SEMR
$1.17M 0.07%
125,000
+90,000
+257% +$1.23M
PEGA icon
98
Pegasystems
PEGA
$5.38B
$1.15M 0.06%
+33,000
New +$1.46M
MDB icon
99
MongoDB
MDB
$32.1B
$965K 0.05%
+5,500
New +$1.34M
NKE icon
100
Nike
NKE
$61.9B
$952K 0.05%
+15,000
New +$1.1M
2 3
4
5 6

Similar funds

SCM
Saba Capital Management New York $3.62B AUM 12.96% 1-Year Est. Return
ACM
Advent Capital Management New York $3.63B AUM 0.29% 1-Year Est. Return
GCM
Ghisallo Capital Management Boston, Massachusetts $3.63B AUM 30.51% 1-Year Est. Return
VI
Vestcor Inc Fredericton, New Brunswick, Canada $3.63B AUM 21.49% 1-Year Est. Return
BPS
BNDES Participacoes SA Rio De Janeiro, Brazil $3.58B AUM
VPC
Vestal Point Capital New York $3.58B AUM 189.12% 1-Year Est. Return
WWA
WCG Wealth Advisors Las Vegas, Nevada $3.57B AUM 18.63% 1-Year Est. Return
OCM
One Capital Management Westlake Village, California $3.65B AUM 15.32% 1-Year Est. Return

Siren LLC's Q1 2025 Portfolio in Review

As of Q1 2025, Siren LLC held 141 positions worth $1.77B, down 22% from $2.26B the previous quarter. Its ten largest holdings account for 50% of the portfolio.

Siren LLC's Q1 2025 filing shows 23 new, 28 increased, 41 reduced and 25 closed positions. Its largest new stake was Blueprint Medicines: 726,167 shares worth $64.3M. The largest sale was argenx, an estimated $70.8M.

By sector, the portfolio is most concentrated in Healthcare at 90% of assets, down from 93% a quarter earlier, followed by Technology and Communication Services.

  • Siren LLC's largest Q1 2025 buy was Blueprint Medicines: 726,167 shares worth $64.3M.
  • Siren LLC added most to Edgewise Therapeutics in Q1 2025, an estimated $25.2M increase.
  • Siren LLC's biggest Q1 2025 reduction was BeOne Medicines Ltd, cutting an estimated $36.2M.
  • Siren LLC fully exited argenx in Q1 2025, selling an estimated $70.8M.
  • Siren LLC's ten largest holdings make up 50% of its $1.77B portfolio in Q1 2025.
  • Siren LLC opened 23 new positions and closed 25 in Q1 2025.
  • Siren LLC's portfolio value fell 22% quarter-over-quarter to $1.77B.

Based on Siren LLC's 13F filing for Q1 2025, filed 14 May 2025.