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Sio Capital Management Portfolio holdings

AUM $697M
1-Year Est. Return 79.73%
This Fund
S&P 500
This Quarter Est. Return
+16.87%
1 Year Est. Return
+79.73%
3 Year Est. Return
+576.62%
5 Year Est. Return
+422.76%
10 Year Est. Return
+2,506.65%
AUM
$493M
AUM Growth
+$4.13M
Cap. Flow
-$34.1M
Cap. Flow %
-6.93%
Top 10 Hldgs %
38.08%
Holding
111
New
22
Increased
19
Reduced
35
Closed
22

Top Buys

Rank Stock Value
1
CNC icon
Centene
CNC
+$13.5M
2
CI icon
Cigna
CI
+$9.96M
3
MRK icon
Merck
MRK
+$9.66M
4
ICLR icon
Icon
ICLR
+$9.38M
5
GSK icon
GSK
GSK
+$9.35M

Top Sells

Rank Stock Value
1
AZN icon
AstraZeneca
AZN
+$13.1M
2
COR icon
Cencora
COR
+$12.5M
3
WBA
Walgreens Boots Alliance
WBA
+$12.3M
4
SNY icon
Sanofi
SNY
+$10.7M
5
AMGN icon
Amgen
AMGN
+$9.2M

Sector Composition

Rank Sector Weight
1 Healthcare 87.45%
2 Consumer Staples 1.34%
3 Technology 0.67%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
AHACU
76
DELISTED
Alpha Healthcare Acquisition Corp Unit
AHACU
$1.25M 0.25%
100,000
– –
SIOX
77
DELISTED
Sio Gene Therapies Inc. Common Stock
SIOX
$1.2M 0.24%
460,248
-426,417
-48% -$1.21M
ETON icon
78
Eton Pharmaceutcials
ETON
$1.24B
$1.19M 0.24%
+162,659
New +$1.39M
IDYA icon
79
IDEAYA Biosciences
IDYA
$3.52B
$1.14M 0.23%
48,298
– –
CBIO
80
Crescent Biopharma
CBIO
$619M
$1.07M 0.22%
+3,555
New +$1.27M
NBP
81
NovaBridge Biosciences American Depositary Shares
NBP
$201M
$727K 0.15%
15,000
– –
DFHTU
82
DELISTED
Deerfield Healthcare Technology Acquisitions Corp. Unit
DFHTU
$655K 0.13%
50,000
– –
CASI
83
DELISTED
CASI Pharmaceuticals
CASI
$488K 0.1%
20,343
– –
NGNE icon
84
Neurogene
NGNE
$707M
$472K 0.1%
1,916
– –
MESO
85
PUT
Mesoblast
MESO
$2.06B
$468K 0.1%
28,300
-180,350
-86% -$3.41M
RAPT
86
DELISTED
RAPT Therapeutics
RAPT
$317K 0.06%
1,787
– –
APTO
87
DELISTED
Aptose Biosciences, Inc.
APTO
$246K 0.05%
+91
New +$180K
BNGO icon
88
Bionano Genomics
BNGO
$13M
$196K 0.04%
+40
New +$226K
TRIL
89
DELISTED
Trillium Therapeutics Inc.
TRIL
$166K 0.03%
15,500
– –
AGIO icon
90
Agios Pharmaceuticals
AGIO
$1.91B
– –
-35,000
Closed -$1.52M
AMGN icon
91
Amgen
AMGN
$221B
– –
-40,000
Closed -$9.2M
AZN icon
92
AstraZeneca
AZN
$248B
– –
-131,500
Closed -$13.1M
BDX icon
93
Becton Dickinson
BDX
$48.6B
– –
-27,997
Closed -$6.83M
BMRN icon
94
BioMarin Pharmaceuticals
BMRN
$12.2B
– –
-100,844
Closed -$8.84M
COR icon
95
Cencora
COR
$61.7B
– –
-127,781
Closed -$12.5M
CRDF icon
96
Cardiff Oncology
CRDF
$77M
– –
-149,833
Closed -$2.69M
IONS icon
97
Ionis Pharmaceuticals
IONS
$9.25B
– –
-81,026
Closed -$4.58M
ITGR icon
98
Integer Holdings
ITGR
$4.26B
– –
-46,699
Closed -$3.79M
MED icon
99
PUT
Medifast
MED
$143M
– –
-18,200
Closed -$3.57M
MOH icon
100
Molina Healthcare
MOH
$10.2B
– –
-18,763
Closed -$3.99M
1 2 3
4
5

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Sio Capital Management's Q1 2021 Portfolio in Review

As of Q1 2021, Sio Capital Management held 111 positions worth $493M, up 0.85% from $489M the previous quarter. Its ten largest holdings account for 38% of the portfolio.

Sio Capital Management withdrew a net $34.1M in Q1 2021, closing 22 positions and reducing 35 holdings. Its most notable exit was AstraZeneca, an estimated $13.1M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 87% of assets, up from 82% a quarter earlier, followed by Consumer Staples and Technology.

Against the trend, Sio Capital Management opened a new position in Centene worth $13.9M.

  • Sio Capital Management's largest Q1 2021 buy was Centene: 217,500 shares worth $13.9M.
  • Sio Capital Management added most to Cigna in Q1 2021, an estimated $9.96M increase.
  • Sio Capital Management's biggest Q1 2021 reduction was Curis, cutting an estimated $3.92M.
  • Sio Capital Management fully exited AstraZeneca in Q1 2021, selling an estimated $13.1M.
  • Sio Capital Management's ten largest holdings make up 38% of its $493M portfolio in Q1 2021.
  • Sio Capital Management opened 22 new positions and closed 22 in Q1 2021.
  • Sio Capital Management's portfolio value rose 0.85% quarter-over-quarter to $493M.

Based on Sio Capital Management's 13F filing for Q1 2021, filed 14 May 2021.