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Sio Capital Management Portfolio holdings

AUM $697M
1-Year Est. Return 79.73%
This Fund
S&P 500
This Quarter Est. Return
+130.68%
1 Year Est. Return
+79.73%
3 Year Est. Return
+576.62%
5 Year Est. Return
+422.76%
10 Year Est. Return
+2,506.65%
AUM
$355M
AUM Growth
+$103M
Cap. Flow
+$153M
Cap. Flow %
42.91%
Top 10 Hldgs %
59.98%
Holding
61
New
22
Increased
9
Reduced
5
Closed
10

Top Buys

Rank Stock Value
1
ICLR icon
Icon
ICLR
+$45.7M
2
CI icon
Cigna
CI
+$22.8M
3
QTTB icon
Q32 Bio
QTTB
+$22M
4
SNY icon
Sanofi
SNY
+$19.7M
5
MMS icon
Maximus
MMS
+$18.5M

Top Sells

Rank Stock Value
1
TEVA icon
Teva Pharmaceuticals
TEVA
+$24.3M
2
LH icon
Labcorp
LH
+$13.8M
3
KVUE icon
Kenvue
KVUE
+$11M
4
BDSX icon
Biodesix
BDSX
+$7.72M
5
RLAY icon
Relay Therapeutics
RLAY
+$6.7M

Sector Composition

Rank Sector Weight
1 Healthcare 91.96%
2 Industrials 8.01%
3 Consumer Staples 0%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
SVRA icon
51
Savara
SVRA
$1.13B
$11.5K ﹤0.01%
+3,747
New +$13.1K
BDSX icon
52
Biodesix
BDSX
$236M
– –
-216,926
Closed -$7.72M
CMPS
53
Compass Pathways
CMPS
$1.83B
– –
-914,639
Closed -$5.76M
ISRG icon
54
PUT
Intuitive Surgical
ISRG
$133B
– –
-59,000
Closed -$29M
KVUE icon
55
Kenvue
KVUE
$37.8B
– –
-474,741
Closed -$11M
RAPT
56
DELISTED
RAPT Therapeutics
RAPT
– –
-39,375
Closed -$633K
RLAY icon
57
Relay Therapeutics
RLAY
$4.29B
– –
-945,839
Closed -$6.7M
TEVA icon
58
Teva Pharmaceuticals
TEVA
$40.5B
– –
-1,349,274
Closed -$24.3M
VSTM icon
59
Verastem
VSTM
$516M
– –
-133,412
Closed -$399K
XFOR icon
60
X4 Pharmaceuticals
XFOR
$391M
– –
-43,450
Closed -$872K
CMAXW
61
DELISTED
CareMax, Inc. Warrant
CMAXW
– –
-12,808
Closed -$108
1 2
3

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Sio Capital Management's Q4 2024 Portfolio in Review

As of Q4 2024, Sio Capital Management held 61 positions worth $355M, up 41% from $252M the previous quarter. Its ten largest holdings account for 60% of the portfolio.

Sio Capital Management deployed $153M of net new capital in Q4 2024, opening 22 new positions and adding to 9 existing holdings. Its largest new stake was Icon: 195,500 shares worth $41M.

By sector, the portfolio is most concentrated in Healthcare at 92% of assets, up from 78% a quarter earlier, followed by Industrials and Consumer Staples.

On the sell side, the largest reduction was Labcorp, an estimated $13.8M trimmed.

  • Sio Capital Management's largest Q4 2024 buy was Icon: 195,500 shares worth $41M.
  • Sio Capital Management added most to Cigna in Q4 2024, an estimated $22.8M increase.
  • Sio Capital Management's biggest Q4 2024 reduction was Labcorp, cutting an estimated $13.8M.
  • Sio Capital Management fully exited Teva Pharmaceuticals in Q4 2024, selling an estimated $24.3M.
  • Sio Capital Management's ten largest holdings make up 60% of its $355M portfolio in Q4 2024.
  • Sio Capital Management opened 22 new positions and closed 10 in Q4 2024.
  • Sio Capital Management's portfolio value rose 41% quarter-over-quarter to $355M.

Based on Sio Capital Management's 13F filing for Q4 2024, filed 14 Feb 2025.