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Sio Capital Management Portfolio holdings

AUM $697M
1-Year Est. Return 79.73%
This Fund
S&P 500
This Quarter Est. Return
+16.87%
1 Year Est. Return
+79.73%
3 Year Est. Return
+576.62%
5 Year Est. Return
+422.76%
10 Year Est. Return
+2,506.65%
AUM
$493M
AUM Growth
+$4.13M
Cap. Flow
-$34.1M
Cap. Flow %
-6.93%
Top 10 Hldgs %
38.08%
Holding
111
New
22
Increased
19
Reduced
35
Closed
22

Top Buys

Rank Stock Value
1
CNC icon
Centene
CNC
+$13.5M
2
CI icon
Cigna
CI
+$9.96M
3
MRK icon
Merck
MRK
+$9.66M
4
ICLR icon
Icon
ICLR
+$9.38M
5
GSK icon
GSK
GSK
+$9.35M

Top Sells

Rank Stock Value
1
AZN icon
AstraZeneca
AZN
+$13.1M
2
COR icon
Cencora
COR
+$12.5M
3
WBA
Walgreens Boots Alliance
WBA
+$12.3M
4
SNY icon
Sanofi
SNY
+$10.7M
5
AMGN icon
Amgen
AMGN
+$9.2M

Sector Composition

Rank Sector Weight
1 Healthcare 87.45%
2 Consumer Staples 1.34%
3 Technology 0.67%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
GYRE icon
51
Gyre Therapeutics
GYRE
$695M
$3.14M 0.64%
83,186
+58,024
+231% +$2.65M
EUCRU
52
DELISTED
Eucrates Biomedical Acquisition Corp. Unit
EUCRU
$3M 0.61%
300,000
– –
NBSE
53
DELISTED
NeuBase Therapeutics, Inc. Common Stock
NBSE
$2.91M 0.59%
19,685
+5,000
+34% +$906K
OBIO icon
54
Orchestra BioMed
OBIO
$253M
$2.8M 0.57%
250,000
– –
LRMR icon
55
Larimar Therapeutics
LRMR
$426M
$2.73M 0.56%
187,223
-1,438
-0.8% -$26.1K
ONCT
56
DELISTED
Oncternal Therapeutics, Inc. Common Stock
ONCT
$2.69M 0.55%
16,167
– –
FUSN
57
DELISTED
Fusion Pharmaceuticals Inc. Common Shares
FUSN
$2.67M 0.54%
249,419
+76,726
+44% +$897K
PRQR icon
58
ProQR Therapeutics
PRQR
$278M
$2.6M 0.53%
+392,821
New +$2.01M
CBAY
59
DELISTED
Cymabay Therapeutics
CBAY
$2.55M 0.52%
562,339
-25,000
-4% -$135K
MRSN
60
DELISTED
Mersana Therapeutics
MRSN
$2.54M 0.52%
6,290
-1,108
-15% -$537K
GOSS icon
61
Gossamer Bio
GOSS
$86.9M
$2.42M 0.49%
+261,400
New +$2.64M
FULC icon
62
Fulcrum Therapeutics
FULC
$288M
$2.25M 0.46%
191,272
+45,000
+31% +$556K
VINC
63
DELISTED
Vincerx Pharma, Inc. Common Stock
VINC
$2.03M 0.41%
5,250
-2,245
-30% -$906K
LLY icon
64
CALL
Eli Lilly
LLY
$1.04T
$1.79M 0.36%
+9,600
New +$1.88M
BCEL
65
DELISTED
Atreca, Inc. Class A Common Stock
BCEL
$1.74M 0.35%
113,455
-15,000
-12% -$244K
RVLP
66
DELISTED
RVL Pharmaceuticals plc Ordinary Shares
RVLP
$1.69M 0.34%
+519,039
New +$2.13M
AVTX icon
67
Avalo Therapeutics
AVTX
$997M
$1.67M 0.34%
192
-130
-40% -$1.23M
ANIK icon
68
Anika Therapeutics
ANIK
$257M
$1.63M 0.33%
40,000
-25,382
-39% -$963K
RUBY
69
DELISTED
Rubius Therapeutics, Inc
RUBY
$1.58M 0.32%
+59,800
New +$873K
KRRO icon
70
PUT
Korro Bio
KRRO
$166M
$1.55M 0.31%
+3,262
New +$6.34M
ARNA
71
DELISTED
Arena Pharmaceuticals Inc
ARNA
$1.51M 0.31%
21,738
-36,000
-62% -$2.77M
LITS
72
Lite Strategy Inc
LITS
$32.5M
$1.46M 0.3%
21,302
– –
HROW icon
73
Harrow
HROW
$1.47B
$1.42M 0.29%
209,623
– –
IOVA icon
74
Iovance Biotherapeutics
IOVA
$1.94B
$1.41M 0.29%
44,430
-9,570
-18% -$397K
SRRA
75
DELISTED
Sierra Oncology, Inc. Common Stock
SRRA
$1.4M 0.28%
80,952
+14,497
+22% +$230K
1 2
3
4 5

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Sio Capital Management's Q1 2021 Portfolio in Review

As of Q1 2021, Sio Capital Management held 111 positions worth $493M, up 0.85% from $489M the previous quarter. Its ten largest holdings account for 38% of the portfolio.

Sio Capital Management withdrew a net $34.1M in Q1 2021, closing 22 positions and reducing 35 holdings. Its most notable exit was AstraZeneca, an estimated $13.1M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 87% of assets, up from 82% a quarter earlier, followed by Consumer Staples and Technology.

Against the trend, Sio Capital Management opened a new position in Centene worth $13.9M.

  • Sio Capital Management's largest Q1 2021 buy was Centene: 217,500 shares worth $13.9M.
  • Sio Capital Management added most to Cigna in Q1 2021, an estimated $9.96M increase.
  • Sio Capital Management's biggest Q1 2021 reduction was Curis, cutting an estimated $3.92M.
  • Sio Capital Management fully exited AstraZeneca in Q1 2021, selling an estimated $13.1M.
  • Sio Capital Management's ten largest holdings make up 38% of its $493M portfolio in Q1 2021.
  • Sio Capital Management opened 22 new positions and closed 22 in Q1 2021.
  • Sio Capital Management's portfolio value rose 0.85% quarter-over-quarter to $493M.

Based on Sio Capital Management's 13F filing for Q1 2021, filed 14 May 2021.