PAI

Palo Alto Investors Portfolio holdings

AUM $470M
1-Year Return 2.57%
This Quarter Return
+28.06%
1 Year Return
+2.57%
3 Year Return
+93.77%
5 Year Return
+190.64%
10 Year Return
+955.02%
AUM
$1.82B
AUM Growth
+$156M
Cap. Flow
-$58.8M
Cap. Flow %
-3.23%
Top 10 Hldgs %
79.73%
Holding
45
New
4
Increased
25
Reduced
5
Closed
2

Top Buys

1
BMRN icon
BioMarin Pharmaceuticals
BMRN
+$24.8M
2
EHTH icon
eHealth
EHTH
+$22.2M
3
KPTI icon
Karyopharm Therapeutics
KPTI
+$12.7M
4
ACAD icon
Acadia Pharmaceuticals
ACAD
+$11M
5
GOSS icon
Gossamer Bio
GOSS
+$10.8M

Top Sells

1
AIMT
Aimmune Therapeutics, Inc.
AIMT
+$114M
2
MNTA
Momenta Pharmaceuticals, Inc.
MNTA
+$49.2M
3
IMMU
Immunomedics Inc
IMMU
+$28.1M
4
RIGL icon
Rigel Pharmaceuticals
RIGL
+$5.66M
5
STAA icon
STAAR Surgical
STAA
+$1.67M

Sector Composition

1 Healthcare 74.2%
2 Financials 1.22%
Name Market Value Portfolio Weight Shares or Principal Shares
Change % 		Capital Flow
ZGNX
26
DELISTED
Zogenix, Inc.
ZGNX
$2.93M 0.16%
163,600
+59,500
+57% +$1.07M
SNDX icon
27
Syndax Pharmaceuticals
SNDX
$1.34B
$2.93M 0.16%
198,400
+70,700
+55% +$1.04M
TVTX icon
28
Travere Therapeutics
TVTX
$2.09B
$2.92M 0.16%
157,900
+110,900
+236% +$2.05M
APRE icon
29
Aprea Therapeutics
APRE
$8.97M
$2.88M 0.16%
5,990
+3,628
+154% +$1.75M
RIGL icon
30
Rigel Pharmaceuticals
RIGL
$681M
$2.84M 0.16%
118,409
-235,846
-67% -$5.66M
CYTK icon
31
Cytokinetics
CYTK
$6.12B
$2.68M 0.15%
123,686
– –
KZR icon
32
Kezar Life Sciences
KZR
$28.9M
$2.37M 0.13%
48,932
+28,423
+139% +$1.38M
DNTH icon
33
Dianthus Therapeutics
DNTH
$1.48B
$2.34M 0.13%
21,481
+9,318
+77% +$1.01M
TCDA
34
DELISTED
Tricida, Inc. Common Stock
TCDA
$1.55M 0.08%
+170,800
New +$1.55M
EOLS icon
35
Evolus
EOLS
$465M
$1.04M 0.06%
+265,700
New +$1.04M
ALIM
36
DELISTED
Alimera Sciences, Inc.
ALIM
$976K 0.05%
200,919
– –
ALDX icon
37
Aldeyra Therapeutics
ALDX
$324M
$874K 0.05%
118,000
+44,500
+61% +$330K
AIMT
38
DELISTED
Aimmune Therapeutics, Inc.
AIMT
$682K 0.04%
19,800
-3,298,412
-99% -$114M
URGN icon
39
UroGen Pharma
URGN
$869M
$473K 0.03%
24,500
– –
MRNS
40
DELISTED
Marinus Pharmaceuticals, Inc
MRNS
$403K 0.02%
31,330
– –
ACGN
41
DELISTED
Aceragen, Inc. Common Stock
ACGN
$165K 0.01%
4,537
– –
VIRX
42
DELISTED
Viracta Therapeutics, Inc. Common Stock
VIRX
$145K 0.01%
33,213
-1
-0% -$4
NERV icon
43
Minerva Neurosciences
NERV
$15.2M
$115K 0.01%
4,540
– –
ITCI
44
DELISTED
Intra-Cellular Therapies Inc.
ITCI
– –
-37,400
Closed -$960K
MNTA
45
DELISTED
Momenta Pharmaceuticals, Inc.
MNTA
– –
-1,479,524
Closed -$49.2M
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