PAI

Palo Alto Investors Portfolio holdings

AUM $470M
1-Year Return 2.57%
This Quarter Return
+38.02%
1 Year Return
+2.57%
3 Year Return
+93.77%
5 Year Return
+190.64%
10 Year Return
+955.02%
AUM
$1.72B
AUM Growth
+$398M
Cap. Flow
+$24.8M
Cap. Flow %
1.44%
Top 10 Hldgs %
68.24%
Holding
45
New
–
Increased
23
Reduced
5
Closed
3

Top Buys

1
ALXN
Alexion Pharmaceuticals Inc
ALXN
+$27.2M
2
SAGE
Sage Therapeutics
SAGE
+$22.3M
3
FOLD icon
Amicus Therapeutics
FOLD
+$12.4M
4
PRTA icon
Prothena Corp
PRTA
+$8.75M
5
UTHR icon
United Therapeutics
UTHR
+$5.29M

Top Sells

1
ABMD
Abiomed Inc
ABMD
+$23.5M
2
MDVN
MEDIVATION, INC.
MDVN
+$16.5M
3
HTWR
HEARTWARE INTERNATIONAL INC COM STK (DE)
HTWR
+$15.8M
4
SQNM
SEQUENOM INC NEW
SQNM
+$9.43M
5
VNDA icon
Vanda Pharmaceuticals
VNDA
+$1.91M

Sector Composition

1 Healthcare 94.83%
Name Market Value Portfolio Weight Shares or Principal Shares
Change % 		Capital Flow
EXAS icon
26
Exact Sciences
EXAS
$10.2B
$7.37M 0.43%
396,976
+700
+0.2% +$13K
TLPH icon
27
Talphera
TLPH
$19.3M
$6.36M 0.37%
81,730
+10,458
+15% +$814K
AIMT
28
DELISTED
Aimmune Therapeutics, Inc.
AIMT
$5.7M 0.33%
379,727
+54,128
+17% +$812K
VIRX
29
DELISTED
Viracta Therapeutics, Inc. Common Stock
VIRX
$5.08M 0.3%
33,214
– –
ALIM
30
DELISTED
Alimera Sciences, Inc.
ALIM
$4.49M 0.26%
200,920
– –
ALGN icon
31
Align Technology
ALGN
$9.54B
$3.51M 0.2%
37,457
+1,100
+3% +$103K
ACGN
32
DELISTED
Aceragen, Inc. Common Stock
ACGN
$3.22M 0.19%
9,257
– –
DRNA
33
DELISTED
Dicerna Pharmaceuticals, Inc.
DRNA
$1.58M 0.09%
267,890
– –
OCGN icon
34
Ocugen
OCGN
$334M
$1.46M 0.08%
7,576
– –
PGEN icon
35
Precigen
PGEN
$1.13B
$1.32M 0.08%
47,524
– –
CYTK icon
36
Cytokinetics
CYTK
$6.12B
$1.14M 0.07%
123,686
– –
SPHS
37
DELISTED
Sophiris Bio, Inc.
SPHS
$768K 0.04%
247,000
-247,000
-50% -$768K
ARCT icon
38
Arcturus Therapeutics
ARCT
$470M
$674K 0.04%
38,970
– –
OREX
39
DELISTED
Orexigen Therapeutics, Inc.
OREX
$555K 0.03%
167,302
– –
ZGNX
40
DELISTED
Zogenix, Inc.
ZGNX
$337K 0.02%
29,500
– –
QURE icon
41
uniQure
QURE
$904M
$156K 0.01%
20,453
– –
MRNS
42
DELISTED
Marinus Pharmaceuticals, Inc
MRNS
$116K 0.01%
15,879
– –
SQNM
43
DELISTED
SEQUENOM INC NEW
SQNM
– –
-10,322,377
Closed -$9.43M
HTWR
44
DELISTED
HEARTWARE INTERNATIONAL INC COM STK (DE)
HTWR
– –
-272,986
Closed -$15.8M
MDVN
45
DELISTED
MEDIVATION, INC.
MDVN
– –
-273,983
Closed -$16.5M
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