PAI

Palo Alto Investors Portfolio holdings

AUM $470M
This Quarter Return
-1.66%
1 Year Return
+2.57%
3 Year Return
+93.77%
5 Year Return
+190.64%
10 Year Return
+955.02%
AUM
$1.8B
AUM Growth
+$1.8B
Cap. Flow
-$111M
Cap. Flow %
-6.19%
Top 10 Hldgs %
74.06%
Holding
48
New
1
Increased
18
Reduced
7
Closed
5

Top Buys

1
CEMP
Cempra, Inc.
CEMP
$36.6M
2
CLVS
Clovis Oncology, Inc.
CLVS
$15.4M
3
FOLD icon
Amicus Therapeutics
FOLD
$15.3M
4
EPZM
Epizyme, Inc
EPZM
$8.74M
5
ABMD
Abiomed Inc
ABMD
$5.64M

Top Sells

1
KYTH
KYTHERA BIOPHARMACEUTICALS, INC COM
KYTH
$84.4M
2
ANAC
ANACOR PHARMACEUTICALS INC COM
ANAC
$44.3M
3
BMRN icon
BioMarin Pharmaceuticals
BMRN
$34.5M
4
THOR
THORATEC CORPORATION
THOR
$17M
5
ISRG icon
Intuitive Surgical
ISRG
$13.4M

Sector Composition

1 Healthcare 77.97%
Name Market Value Portfolio Weight Shares or Principal Shares
Change % 		Capital Flow
HTWR
26
DELISTED
HEARTWARE INTERNATIONAL INC COM STK (DE)
HTWR
$12.4M 0.69% 246,068 +2,200 +0.9% +$111K
ALIM
27
DELISTED
Alimera Sciences, Inc.
ALIM
$7.29M 0.41% 3,013,793 – –
VIRX
28
DELISTED
Viracta Therapeutics, Inc. Common Stock
VIRX
$6.26M 0.35% 6,974,854 – –
AIMT
29
DELISTED
Aimmune Therapeutics, Inc.
AIMT
$6.01M 0.33% 325,599 – –
TLPH icon
30
Talphera
TLPH
$11.1M
$5.49M 0.31% 1,425,439 -231,205 -14% -$890K
ACGN
31
DELISTED
Aceragen, Inc. Common Stock
ACGN
$3.89M 0.22% 1,257,748 – –
EXAS icon
32
Exact Sciences
EXAS
$8.98B
$3.66M 0.2% 396,276 +3,600 +0.9% +$33.2K
DRNA
33
DELISTED
Dicerna Pharmaceuticals, Inc.
DRNA
$3.18M 0.18% 267,890 – –
OREX
34
DELISTED
Orexigen Therapeutics, Inc.
OREX
$2.88M 0.16% 1,673,024 -258,300 -13% -$444K
ALGN icon
35
Align Technology
ALGN
$10.3B
$1.83M 0.1% 27,757 – –
ARCT icon
36
Arcturus Therapeutics
ARCT
$462M
$1.6M 0.09% 254,188 – –
OCGN icon
37
Ocugen
OCGN
$319M
$1.59M 0.09% 454,545 – –
PGEN icon
38
Precigen
PGEN
$1.34B
$1.42M 0.08% 47,100 – –
CYTK icon
39
Cytokinetics
CYTK
$4.23B
$1.29M 0.07% 123,686 – –
SPHS
40
DELISTED
Sophiris Bio, Inc.
SPHS
$879K 0.05% 494,000 +302,400 +158% +$538K
MRNS
41
DELISTED
Marinus Pharmaceuticals, Inc
MRNS
$451K 0.03% 59,017 – –
ZGNX
42
DELISTED
Zogenix, Inc.
ZGNX
$422K 0.02% 28,600 +800 +3% +$11.8K
QURE icon
43
uniQure
QURE
$896M
$338K 0.02% 20,453 – –
ISRG icon
44
Intuitive Surgical
ISRG
$170B
– – -29,100 Closed -$13.4M
XOMA icon
45
Xoma
XOMA
$392M
– – -799,000 Closed -$601K
BSTC
46
DELISTED
BioSpecifics Technologies Corp.
BSTC
– – -29,257 Closed -$1.27M
THOR
47
DELISTED
THORATEC CORPORATION
THOR
– – -268,861 Closed -$17M
KYTH
48
DELISTED
KYTHERA BIOPHARMACEUTICALS, INC COM
KYTH
– – -1,125,564 Closed -$84.4M
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