PAI

Palo Alto Investors Portfolio holdings

AUM $470M
1-Year Return 2.57%
This Quarter Return
+12.89%
1 Year Return
+2.57%
3 Year Return
+93.77%
5 Year Return
+190.64%
10 Year Return
+955.02%
AUM
$2.25B
AUM Growth
+$226M
Cap. Flow
+$15.9M
Cap. Flow %
0.71%
Top 10 Hldgs %
73.64%
Holding
48
New
2
Increased
21
Reduced
4
Closed
3

Top Buys

1
CLVS
Clovis Oncology, Inc.
CLVS
+$24.5M
2
KPTI icon
Karyopharm Therapeutics
KPTI
+$21.2M
3
ABMD
Abiomed Inc
ABMD
+$17.7M
4
INSM icon
Insmed
INSM
+$2.06M
5
UTHR icon
United Therapeutics
UTHR
+$1.74M

Top Sells

1
EIGR
Eiger BioPharmaceuticals, Inc.
EIGR
+$27.4M
2
ALGN icon
Align Technology
ALGN
+$16M
3
ANAC
ANACOR PHARMACEUTICALS INC COM
ANAC
+$12.1M
4
KYTH
KYTHERA BIOPHARMACEUTICALS, INC COM
KYTH
+$6.96M
5
QLTI
QLT Inc
QLTI
+$1.24M

Sector Composition

1 Healthcare 69%
Name Market Value Portfolio Weight Shares or Principal Shares
Change % 		Capital Flow
ZLTQ
26
DELISTED
ZELTIQ Aesthetics, Inc.
ZLTQ
$16.8M 0.74%
568,436
– –
RIGL icon
27
Rigel Pharmaceuticals
RIGL
$675M
$16.6M 0.74%
517,632
– –
ISRG icon
28
Intuitive Surgical
ISRG
$161B
$15.7M 0.7%
291,150
– –
ALIM
29
DELISTED
Alimera Sciences, Inc.
ALIM
$13.9M 0.62%
200,920
– –
EXAS icon
30
Exact Sciences
EXAS
$10.3B
$11.7M 0.52%
392,676
– –
OREX
31
DELISTED
Orexigen Therapeutics, Inc.
OREX
$9.56M 0.43%
193,132
– –
TLPH icon
32
Talphera
TLPH
$19.4M
$9.06M 0.4%
106,787
– –
ACGN
33
DELISTED
Aceragen, Inc. Common Stock
ACGN
$4.55M 0.2%
9,029
+416
+5% +$210K
XOMA icon
34
Xoma
XOMA
$451M
$3.1M 0.14%
39,950
+225
+0.6% +$17.5K
OCGN icon
35
Ocugen
OCGN
$331M
$2.94M 0.13%
7,576
– –
VIRX
36
DELISTED
Viracta Therapeutics, Inc. Common Stock
VIRX
$2.73M 0.12%
4,316
+1,443
+50% +$912K
BSTC
37
DELISTED
BioSpecifics Technologies Corp.
BSTC
$2.6M 0.12%
50,436
– –
PGEN icon
38
Precigen
PGEN
$1.15B
$2.3M 0.1%
47,524
-1,758
-4% -$85K
ALGN icon
39
Align Technology
ALGN
$9.61B
$1.74M 0.08%
27,757
-254,300
-90% -$16M
EPZM
40
DELISTED
Epizyme, Inc
EPZM
$1.47M 0.07%
+61,265
New +$1.47M
ARCT icon
41
Arcturus Therapeutics
ARCT
$453M
$1.02M 0.05%
22,370
+11,915
+114% +$545K
DRNA
42
DELISTED
Dicerna Pharmaceuticals, Inc.
DRNA
$986K 0.04%
+70,706
New +$986K
CYTK icon
43
Cytokinetics
CYTK
$6.21B
$831K 0.04%
123,686
– –
MNK
44
DELISTED
MALLINCKRODT PUBLIC LIMITED COMPANY
MNK
$422K 0.02%
3,588
– –
SPHS
45
DELISTED
Sophiris Bio, Inc.
SPHS
$150K 0.01%
191,600
– –
EIGR
46
DELISTED
Eiger BioPharmaceuticals, Inc.
EIGR
– –
-3,211
Closed -$27.4M
QLTI
47
DELISTED
QLT Inc
QLTI
– –
-315,906
Closed -$1.24M
SLXP
48
DELISTED
SALIX PHARMACEUTICALS LTD DEL
SLXP
– –
-5,300
Closed -$916K
1
2