PAI

Palo Alto Investors Portfolio holdings

AUM $470M
This Quarter Return
+35.14%
1 Year Return
+2.57%
3 Year Return
+93.77%
5 Year Return
+190.64%
10 Year Return
+955.02%
AUM
$2.02B
AUM Growth
+$2.02B
Cap. Flow
-$68.7M
Cap. Flow %
-3.4%
Top 10 Hldgs %
71.4%
Holding
52
New
6
Increased
25
Reduced
3
Closed
6

Top Buys

1
THOR
THORATEC CORPORATION
THOR
$95.1M
2
ENDP
Endo International plc
ENDP
$77.2M
3
BMRN icon
BioMarin Pharmaceuticals
BMRN
$43.3M
4
ANAC
ANACOR PHARMACEUTICALS INC COM
ANAC
$42.6M
5
KPTI icon
Karyopharm Therapeutics
KPTI
$29.1M

Top Sells

1
AUXL
AUXILIUM PHARAMCEUTICALS INC
AUXL
$169M
2
CBST
CUBIST PHARMACEUTICALS INC
CBST
$131M
3
CYBX
CYBERONICS INC
CYBX
$77.7M
4
NPSP
NPS PHARMACEUTICALS INC
NPSP
$42.6M
5
SLXP
SALIX PHARMACEUTICALS LTD DEL
SLXP
$12.3M

Sector Composition

1 Healthcare 70.55%
Name Market Value Portfolio Weight Shares or Principal Shares
Change % 		Capital Flow
RIGL icon
26
Rigel Pharmaceuticals
RIGL
$697M
$18.5M 0.91% 5,176,319 – –
ARIA
27
DELISTED
Ariad Pharmaceuticals Inc
ARIA
$18.4M 0.91% 2,231,717 – –
ZLTQ
28
DELISTED
ZELTIQ Aesthetics, Inc.
ZLTQ
$17.5M 0.87% 568,436 +173,950 +44% +$5.36M
ISRG icon
29
Intuitive Surgical
ISRG
$170B
$16.3M 0.81% 32,350 +6,300 +24% +$3.18M
ALGN icon
30
Align Technology
ALGN
$10.3B
$15.2M 0.75% 282,057 +47,757 +20% +$2.57M
OREX
31
DELISTED
Orexigen Therapeutics, Inc.
OREX
$15.1M 0.75% 1,931,324 – –
ALIM
32
DELISTED
Alimera Sciences, Inc.
ALIM
$15.1M 0.75% 3,013,793 – –
EXAS icon
33
Exact Sciences
EXAS
$8.98B
$8.65M 0.43% 392,676 +1,400 +0.4% +$30.8K
TLPH icon
34
Talphera
TLPH
$11.1M
$8.24M 0.41% 2,135,739 +7,200 +0.3% +$27.8K
OCGN icon
35
Ocugen
OCGN
$319M
$4.54M 0.22% 454,545 – –
ACGN
36
DELISTED
Aceragen, Inc. Common Stock
ACGN
$4.34M 0.21% +1,170,248 New +$4.34M
XOMA icon
37
Xoma
XOMA
$392M
$2.89M 0.14% 794,500 – –
PGEN icon
38
Precigen
PGEN
$1.34B
$2.14M 0.11% 47,100 +3,400 +8% +$154K
BSTC
39
DELISTED
BioSpecifics Technologies Corp.
BSTC
$1.98M 0.1% 50,436 – –
VIRX
40
DELISTED
Viracta Therapeutics, Inc. Common Stock
VIRX
$1.48M 0.07% +603,400 New +$1.48M
QLTI
41
DELISTED
QLT Inc
QLTI
$1.24M 0.06% 315,906 -1,417,302 -82% -$5.54M
SLXP
42
DELISTED
SALIX PHARMACEUTICALS LTD DEL
SLXP
$916K 0.05% 5,300 -71,400 -93% -$12.3M
CYTK icon
43
Cytokinetics
CYTK
$4.23B
$839K 0.04% 123,686 – –
MNK
44
DELISTED
MALLINCKRODT PUBLIC LIMITED COMPANY
MNK
$454K 0.02% 3,588 – –
ARCT icon
45
Arcturus Therapeutics
ARCT
$462M
$412K 0.02% +73,188 New +$412K
SPHS
46
DELISTED
Sophiris Bio, Inc.
SPHS
$111K 0.01% 191,600 – –
AVEO
47
DELISTED
AVEO Pharmaceuticals, Inc.
AVEO
– – -669,449 Closed -$562K
NXTM
48
DELISTED
NxStage Medical Inc.
NXTM
– – -20,200 Closed -$362K
HPTX
49
DELISTED
HYPERION THERAPEUTICS INC COM STK (DE)
HPTX
– – -62,700 Closed -$1.51M
NPSP
50
DELISTED
NPS PHARMACEUTICALS INC
NPSP
– – -1,190,263 Closed -$42.6M
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