PAI

Palo Alto Investors Portfolio holdings

AUM $470M
1-Year Return 2.57%
This Quarter Return
+21.71%
1 Year Return
+2.57%
3 Year Return
+93.77%
5 Year Return
+190.64%
10 Year Return
+955.02%
AUM
$1.7B
AUM Growth
+$365M
Cap. Flow
+$87.3M
Cap. Flow %
5.12%
Top 10 Hldgs %
66.83%
Holding
48
New
5
Increased
24
Reduced
10
Closed
2

Top Buys

1
WMGI
Wright Medical Group Inc
WMGI
+$32.4M
2
CLVS
Clovis Oncology, Inc.
CLVS
+$21.3M
3
AMAG
AMAG Pharmaceuticals, Inc.
AMAG
+$16.2M
4
UTHR icon
United Therapeutics
UTHR
+$13.5M
5
ANAC
ANACOR PHARMACEUTICALS INC COM
ANAC
+$13.1M

Top Sells

1
CBST
CUBIST PHARMACEUTICALS INC
CBST
+$54.4M
2
NPSP
NPS PHARMACEUTICALS INC
NPSP
+$18.2M
3
EXAS icon
Exact Sciences
EXAS
+$10.6M
4
GERN icon
Geron
GERN
+$2.32M
5
RVNC
Revance Therapeutics, Inc.
RVNC
+$1.55M

Sector Composition

1 Healthcare 57.95%
Name Market Value Portfolio Weight Shares or Principal Shares
Change % 		Capital Flow
PRTA icon
26
Prothena Corp
PRTA
$442M
$14.4M 0.84%
691,218
+17,400
+3% +$361K
TLPH icon
27
Talphera
TLPH
$19.3M
$14.3M 0.84%
106,427
+25,294
+31% +$3.4M
ISRG icon
28
Intuitive Surgical
ISRG
$161B
$13.8M 0.81%
234,450
+25,200
+12% +$1.48M
ALGN icon
29
Align Technology
ALGN
$9.54B
$13.1M 0.77%
234,300
+21,200
+10% +$1.19M
RIGL icon
30
Rigel Pharmaceuticals
RIGL
$681M
$11.8M 0.69%
517,632
-378
-0.1% -$8.58K
OREX
31
DELISTED
Orexigen Therapeutics, Inc.
OREX
$11.7M 0.69%
193,132
– –
ZLTQ
32
DELISTED
ZELTIQ Aesthetics, Inc.
ZLTQ
$11M 0.65%
394,486
+110,237
+39% +$3.08M
EXAS icon
33
Exact Sciences
EXAS
$10.2B
$10.7M 0.63%
391,276
-386,400
-50% -$10.6M
SLXP
34
DELISTED
SALIX PHARMACEUTICALS LTD DEL
SLXP
$8.82M 0.52%
+76,700
New +$8.82M
THOR
35
DELISTED
THORATEC CORPORATION
THOR
$8.73M 0.51%
+268,861
New +$8.73M
QLTI
36
DELISTED
QLT Inc
QLTI
$6.95M 0.41%
1,733,208
-112,867
-6% -$453K
OCGN icon
37
Ocugen
OCGN
$334M
$5M 0.29%
+7,576
New +$5M
XOMA icon
38
Xoma
XOMA
$452M
$2.85M 0.17%
39,725
+8,480
+27% +$609K
BSTC
39
DELISTED
BioSpecifics Technologies Corp.
BSTC
$1.95M 0.11%
50,436
+15,100
+43% +$583K
HPTX
40
DELISTED
HYPERION THERAPEUTICS INC COM STK (DE)
HPTX
$1.51M 0.09%
62,700
– –
PGEN icon
41
Precigen
PGEN
$1.13B
$1.2M 0.07%
+45,725
New +$1.2M
CYTK icon
42
Cytokinetics
CYTK
$6.12B
$991K 0.06%
123,686
– –
AVEO
43
DELISTED
AVEO Pharmaceuticals, Inc.
AVEO
$562K 0.03%
66,945
-28,858
-30% -$242K
NXTM
44
DELISTED
NxStage Medical Inc.
NXTM
$362K 0.02%
+20,200
New +$362K
MNK
45
DELISTED
MALLINCKRODT PUBLIC LIMITED COMPANY
MNK
$355K 0.02%
3,588
– –
SPHS
46
DELISTED
Sophiris Bio, Inc.
SPHS
$103K 0.01%
191,600
-101,300
-35% -$54.5K
GERN icon
47
Geron
GERN
$810M
– –
-1,161,400
Closed -$2.32M
RVNC
48
DELISTED
Revance Therapeutics, Inc.
RVNC
– –
-80,369
Closed -$1.55M
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