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OrbiMed Portfolio holdings

AUM $5.4B
1-Year Est. Return 163.13%
This Fund
S&P 500
This Quarter Est. Return
+37.76%
1 Year Est. Return
+163.13%
3 Year Est. Return
+393.16%
5 Year Est. Return
+486.34%
10 Year Est. Return
+3,312.73%
AUM
$4.9B
AUM Growth
+$644M
Cap. Flow
-$263M
Cap. Flow %
-5.37%
Top 10 Hldgs %
40.38%
Holding
132
New
23
Increased
22
Reduced
35
Closed
25

Top Buys

Rank Stock Value
1
PFE icon
Pfizer
PFE
+$41.7M
2
BMY icon
Bristol-Myers Squibb
BMY
+$37.3M
3
ELV icon
Elevance Health
ELV
+$33.5M
4
HELP
Cybin Inc
HELP
+$24.7M
5
BRKR icon
Bruker
BRKR
+$23.5M

Top Sells

Rank Stock Value
1
TERN
Terns Pharmaceuticals
TERN
+$125M
2
RNAM
Avidity Biosciences
RNAM
+$65.8M
3
EXAS
Exact Sciences
EXAS
+$51.6M
4
AXSM icon
Axsome Therapeutics
AXSM
+$38.9M
5
SIBN icon
SI-BONE Inc
SIBN
+$38M

Sector Composition

Rank Sector Weight
1 Healthcare 99.3%
2 Miscellaneous 0.7%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
EWTX icon
1
Edgewise Therapeutics
EWTX
$4.64B
$385M 7.86%
15,518,492
– –
LLY icon
2
Eli Lilly
LLY
$1.05T
$324M 6.61%
301,200
– –
BSX icon
3
Boston Scientific
BSX
$67.9B
$231M 4.71%
2,419,300
-10,000
-0.4% -$980K
SVA
4
DELISTED
Sinovac Biotech, Ltd
SVA
$184M 3.77%
2,718,735
– –
EW icon
5
Edwards Lifesciences
EW
$52B
$157M 3.21%
1,842,900
+158,900
+9% +$13M
UPB
6
Upstream Bio Inc
UPB
$366M
$155M 3.16%
5,693,589
– –
ISRG icon
7
Intuitive Surgical
ISRG
$132B
$149M 3.04%
263,400
-23,800
-8% -$12.7M
SION
8
Sionna Therapeutics
SION
$265M
$147M 2.99%
3,561,655
-143,304
-4% -$5.43M
MBX
9
MBX Biosciences
MBX
$3.03B
$124M 2.53%
3,935,203
-67,684
-2% -$1.64M
ARGX icon
10
argenx
ARGX
$64B
$123M 2.51%
146,000
-26,300
-15% -$22.5M
ELVN icon
11
Enliven Therapeutics
ELVN
$4.24B
$123M 2.5%
7,959,538
– –
ALNY icon
12
Alnylam Pharmaceuticals
ALNY
$31.7B
$115M 2.34%
288,800
-12,800
-4% -$5.66M
SYK icon
13
Stryker
SYK
$127B
$114M 2.33%
325,000
-34,200
-10% -$12.5M
SPRY icon
14
ARS Pharmaceuticals
SPRY
$586M
$96.6M 1.97%
8,288,510
– –
TERN
15
DELISTED
Terns Pharmaceuticals
TERN
$87M 1.78%
2,153,300
-5,409,671
-72% -$125M
IRON icon
16
Disc Medicine
IRON
$3.07B
$84.8M 1.73%
1,067,550
-347,470
-25% -$29.4M
CAI
17
Caris Life Sciences
CAI
$7.24B
$84.1M 1.72%
3,116,011
+81,153
+3% +$2.29M
NTRA icon
18
Natera
NTRA
$47B
$83.8M 1.71%
365,800
-63,500
-15% -$13.2M
CMPX icon
19
Compass Therapeutics
CMPX
$432M
$81.7M 1.67%
15,219,994
– –
GPCR icon
20
Structure Therapeutics
GPCR
$3.38B
$80.8M 1.65%
1,161,803
+22,503
+2% +$919K
DHR icon
21
Danaher
DHR
$152B
$68.6M 1.4%
299,800
+36,700
+14% +$8.07M
CGON icon
22
CG Oncology
CGON
$6.59B
$63M 1.29%
1,516,550
-210,300
-12% -$8.7M
APLS
23
DELISTED
Apellis Pharmaceuticals
APLS
$61M 1.25%
2,429,868
+106,500
+5% +$2.5M
AVBP icon
24
ArriVent BioPharma
AVBP
$1.49B
$60.9M 1.24%
3,027,328
– –
CI icon
25
Cigna
CI
$73.7B
$56.4M 1.15%
205,000
+42,200
+26% +$11.8M
1
2 3 4 5

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OrbiMed's Q4 2025 Portfolio in Review

As of Q4 2025, OrbiMed held 132 positions worth $4.9B, up 15% from $4.26B the previous quarter. Its ten largest holdings account for 40% of the portfolio.

OrbiMed withdrew a net $263M in Q4 2025, closing 25 positions and reducing 35 holdings. Its most notable exit was SI-BONE Inc, an estimated $38M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 99% of assets, up from 98% a quarter earlier, followed by Miscellaneous.

Against the trend, OrbiMed opened a new position in Pfizer worth $41.2M.

  • OrbiMed's largest Q4 2025 buy was Pfizer: 1,652,900 shares worth $41.2M.
  • OrbiMed added most to RAPT Therapeutics in Q4 2025, an estimated $17.3M increase.
  • OrbiMed's biggest Q4 2025 reduction was Terns Pharmaceuticals, cutting an estimated $125M.
  • OrbiMed fully exited SI-BONE Inc in Q4 2025, selling an estimated $38M.
  • OrbiMed's ten largest holdings make up 40% of its $4.9B portfolio in Q4 2025.
  • OrbiMed opened 23 new positions and closed 25 in Q4 2025.
  • OrbiMed's portfolio value rose 15% quarter-over-quarter to $4.9B.

Based on OrbiMed's 13F filing for Q4 2025, filed 17 Feb 2026.