O
MBX

OrbiMed’s MBX Biosciences MBX Stock Holding History

OrbiMed’s Portfolio MBX Stock Details MBX Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$109M Sell
3,637,887
-297,316
-8% -$10.1M 2.15% 11
2025
Q4 		$124M Sell
3,935,203
-67,684
-2% -$1.64M 2.53% 9
2025
Q3 		$70.1M Hold
4,002,887
– – 1.65% 17
2025
Q2 		$45.7M Hold
4,002,887
– – 1.14% 26
2025
Q1 		$29.5M Buy
4,002,887
+190,672
+5% +$2.02M 0.7% 38
2024
Q4 		$70.3M Hold
3,812,215
– – 1.45% 23
2024
Q3 		$99M Buy
+3,812,215
New +$87.2M 1.8% 16

Other funds holding MBX

FLSM
Frazier Life Sciences Management Palo Alto, California $3.89B AUM 201.1% 1-Year Est. Return
NMC
NEA Management Company Timonium, Maryland $1.76B AUM 223.33% 1-Year Est. Return
Wellington Management Group
Wellington Management Group Boston, Massachusetts $535B AUM 26.23% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
DTC
Deep Track Capital Greenwich, Connecticut $6.12B AUM 144% 1-Year Est. Return
NA
NVP Associates Menlo Park, California $176M AUM 208.78% 1-Year Est. Return
PCH
Polar Capital Holdings London, United Kingdom $28.2B AUM 115.26% 1-Year Est. Return
B
Braidwell Stamford, Connecticut $3B AUM 46.72% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM

OrbiMed's MBX Position: Q1 2026 in Review

OrbiMed reduced its MBX Biosciences (MBX) stake by 7.6% in Q1 2026, selling an estimated $10.1M and leaving 3,637,887 shares worth $109M. The position accounts for 2.15% of the portfolio, ranked #11.

OrbiMed first reported a position in MBX in Q3 2024 and has held it in 7 quarters since. The position peaked at $124M in Q4 2025. 157 funds tracked by Wall St. Rank hold MBX as of Q1 2026.

  • OrbiMed held 3,637,887 shares of MBX Biosciences worth $109M as of Q1 2026.
  • OrbiMed sold 297,316 MBX Biosciences shares in Q1 2026, an estimated $10.1M.
  • MBX Biosciences made up 2.15% of OrbiMed's portfolio in Q1 2026, its #11 holding.
  • OrbiMed first reported a position in MBX Biosciences in Q3 2024 and has held it in 7 quarters since.
  • OrbiMed's MBX Biosciences position peaked at $124M in Q4 2025.
  • 157 funds tracked by Wall St. Rank held MBX Biosciences as of Q1 2026.

Based on OrbiMed's 13F filing for Q1 2026, filed 15 May 2026.