OM

Opaleye Management Portfolio holdings

AUM $707M
1-Year Est. Return 67.55%
This Quarter Est. Return
1 Year Est. Return
+67.55%
3 Year Est. Return
5 Year Est. Return
10 Year Est. Return
AUM
$494M
AUM Growth
+$45M
Cap. Flow
Cap. Flow %
Top 10 Hldgs %
Holding
50
New
Increased
Reduced
Closed

Top Buys

1
+$8.55M
2
+$7.95M
3
+$7.56M
4
LRMR icon
Larimar Therapeutics
LRMR
+$6.35M
5
IRON icon
Disc Medicine
IRON
+$5.37M

Top Sells

1
+$7.82M
2
+$4.82M
3
+$4.66M
4
SLRN
ACELYRIN
SLRN
+$3.99M
5
TARA icon
Protara Therapeutics
TARA
+$2.65M

Sector Composition

1 Healthcare 97.87%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
CRGX
26
DELISTED
CARGO Therapeutics
CRGX
$2.75M 0.56%
666,503
MBX
27
MBX Biosciences
MBX
$1.11B
$2.73M 0.55%
239,319
-10,681
ZYME icon
28
Zymeworks
ZYME
$1.4B
$2.64M 0.53%
210,000
+35,000
TARA icon
29
Protara Therapeutics
TARA
$213M
$2.59M 0.52%
855,000
-875,000
ALMS
30
Alumis Inc
ALMS
$574M
$2.33M 0.47%
+775,000
ZNTL icon
31
Zentalis Pharmaceuticals
ZNTL
$96.1M
$2.23M 0.45%
1,924,300
-60,700
TRVI icon
32
Trevi Therapeutics
TRVI
$1.38B
$2.13M 0.43%
390,000
-405,000
RCEL icon
33
Avita Medical
RCEL
$114M
$2.06M 0.42%
389,519
-50,481
IRD
34
Opus Genetics
IRD
$130M
$1.15M 0.23%
1,220,000
+45,000
DERM icon
35
Journey Medical
DERM
$214M
$682K 0.14%
95,000
+25,677
ELEV
36
DELISTED
Elevation Oncology
ELEV
$529K 0.11%
+1,442,061
IBIO icon
37
iBio
IBIO
$23.5M
$285K 0.06%
375,000
PEPG icon
38
PepGen
PEPG
$326M
$266K 0.05%
240,000
-180,000
ADGM
39
Adagio Medical Holdings
ADGM
$16.6M
$144K 0.03%
110,571
ANAB icon
40
AnaptysBio
ANAB
$936M
– –
-250,933
BDSX icon
41
Biodesix
BDSX
$63.6M
– –
-161,250
KNSA icon
42
Kiniksa Pharmaceuticals
KNSA
$3.06B
– –
-62,501
NRIX icon
43
Nurix Therapeutics
NRIX
$1.3B
– –
-115,000
OPTN
44
DELISTED
OptiNose
OPTN
– –
-193,039
SGMO icon
45
Sangamo Therapeutics
SGMO
$150M
– –
-1,055,000
SLRN
46
DELISTED
ACELYRIN
SLRN
– –
-1,615,000
VTYX icon
47
Ventyx Biosciences
VTYX
$660M
– –
-190,000
PVLA
48
Palvella Therapeutics
PVLA
$991M
– –
-172,357
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