Opaleye Management’s Zymeworks ZYME Stock Holding History

Opaleye Management’s Portfolio ZYME Stock Details ZYME Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q1	–	Sell	-108,929	Closed	-$2.87M	–	63
2025 Q4	$2.87M	Buy	108,929 +8,929	+9%	+$195K	0.38%	40
2025 Q3	$1.71M	Sell	100,000 -110,000	-52%	-$1.57M	0.24%	36
2025 Q2	$2.64M	Buy	210,000 +35,000	+20%	+$417K	0.53%	30
2025 Q1	$2.08M	Buy	+175,000	New	+$2.39M	0.46%	31
2020 Q2	–	Sell	-133,000	Closed	-$4.72M	–	54
2020 Q1	$4.72M	Sell	133,000 -42,000	-24%	-$1.72M	1.25%	27
2019 Q4	$7.96M	Buy	175,000 +5,000	+3%	+$182K	1.56%	29
2019 Q3	$4.22M	Hold	170,000	–	–	1.52%	27
2019 Q2	$3.74M	Buy	170,000 +115,000	+209%	+$2.11M	1.14%	30
2019 Q1	$890K	Sell	55,000 -50,000	-48%	-$775K	0.25%	48
2018 Q4	$1.54M	Buy	+105,000	New	+$1.38M	0.58%	37

Other funds holding ZYME

EcoR1 Capital San Francisco, California $2.36B AUM 204.53% 1-Year Est. Return

RCMNY

Rubric Capital Management (New York) New York $9.44B AUM 68.42% 1-Year Est. Return

BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return

BVF Inc San Francisco, California $3.14B AUM 249.53% 1-Year Est. Return

Perceptive Advisors New York $5.12B AUM 314.02% 1-Year Est. Return

Morgan Stanley New York $1.66T AUM 25.57% 1-Year Est. Return

BNP Paribas Asset Management Paris, France $86.1B AUM 29.11% 1-Year Est. Return

VCM

Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM

Citadel Advisors Miami, Florida $618B AUM 30.34% 1-Year Est. Return

Dimensional Fund Advisors Austin, Texas $481B AUM 30.42% 1-Year Est. Return

Opaleye Management's ZYME Position: Q1 2026 in Review

Opaleye Management sold out of Zymeworks (ZYME) in Q1 2026, closing a stake of 108,929 shares — an estimated $2.87M sold.

Opaleye Management first reported a position in ZYME in Q4 2018 and held it in 10 quarters. The position peaked at $7.96M in Q4 2019. 211 funds tracked by Wall St. Rank hold ZYME as of Q1 2026.

Opaleye Management reported no remaining Zymeworks position as of Q1 2026 after selling out during the quarter.
Opaleye Management sold 108,929 Zymeworks shares in Q1 2026, an estimated $2.87M.
Opaleye Management first reported a position in Zymeworks in Q4 2018 and held it in 10 quarters.
Opaleye Management's Zymeworks position peaked at $7.96M in Q4 2019.
211 funds tracked by Wall St. Rank held Zymeworks as of Q1 2026.

Based on Opaleye Management's 13F filing for Q1 2026, filed 15 May 2026.