Opaleye Management’s Codexis CDXS Stock Holding History

Opaleye Management’s Portfolio CDXS Stock Details CDXS Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q1	$11.1M	Sell	6,785,000 -4,738	-0.1%	-$6.75K	1.46%	20
2025 Q4	$11.1M	Sell	6,789,738 -6,005,262	-47%	-$12.2M	1.46%	19
2025 Q3	$31.2M	Buy	12,795,000 +195,000	+2%	+$532K	4.41%	7
2025 Q2	$30.7M	Buy	12,600,000 +3,100,000	+33%	+$7.27M	6.22%	6
2025 Q1	$25.6M	Buy	9,500,000 +660,000	+7%	+$2.56M	5.69%	6
2024 Q4	$42.2M	Buy	8,840,000 +70,000	+0.8%	+$288K	7.38%	3
2024 Q3	$27M	Buy	8,770,000 +5,315,000	+154%	+$16.4M	4.51%	5
2024 Q2	$10.7M	Buy	3,455,000 +335,000	+11%	+$1.08M	2.45%	9
2024 Q1	$10.9M	Buy	3,120,000 +74,475	+2%	+$235K	2.37%	13
2023 Q4	$9.29M	Buy	3,045,525 +1,926,625	+172%	+$4.14M	2.47%	12
2023 Q3	$2.11M	Buy	1,118,900 +443,900	+66%	+$1.04M	0.69%	33
2023 Q2	$1.89M	Sell	675,000 -75,000	-10%	-$243K	0.45%	36
2023 Q1	$3.1M	Sell	750,000 -207,500	-22%	-$1.09M	0.93%	32
2022 Q4	$4.46M	Sell	957,500 -197,500	-17%	-$1.08M	1.55%	20
2022 Q3	$7M	Sell	1,155,000 -133,450	-10%	-$1.07M	2.89%	9
2022 Q2	$13.5M	Sell	1,288,450 -56,550	-4%	-$709K	6.07%	3
2022 Q1	$27.7M	Hold	1,345,000	–	–	8.61%	2
2021 Q4	$42.1M	Hold	1,345,000	–	–	8.92%	1
2021 Q3	$31.3M	Hold	1,345,000	–	–	5.84%	3
2021 Q2	$30.5M	Sell	1,345,000 -55,000	-4%	-$1.19M	5.06%	5
2021 Q1	$32M	Hold	1,400,000	–	–	4.71%	5
2020 Q4	$30.6M	Hold	1,400,000	–	–	3.99%	5
2020 Q3	$16.4M	Hold	1,400,000	–	–	3.21%	9
2020 Q2	$16.1M	Hold	1,400,000	–	–	3.25%	7
2020 Q1	$15.6M	Hold	1,400,000	–	–	4.14%	6
2019 Q4	$22.3M	Buy	1,400,000 +50,000	+4%	+$740K	4.37%	3
2019 Q3	$18.5M	Hold	1,350,000	–	–	6.7%	1
2019 Q2	$24.9M	Sell	1,350,000 -125,000	-8%	-$2.41M	7.58%	1
2019 Q1	$30.3M	Sell	1,475,000 -275,000	-16%	-$5.34M	8.39%	1
2018 Q4	$29.2M	Hold	1,750,000	–	–	10.91%	1
2018 Q3	$30M	Hold	1,750,000	–	–	7.64%	2
2018 Q2	$25.2M	Buy	1,750,000 +49,400	+3%	+$644K	6.52%	3
2018 Q1	$18.7M	Hold	1,700,600	–	–	5.35%	4
2017 Q4	$14.2M	Hold	1,700,600	–	–	4.55%	6
2017 Q3	$11.3M	Buy	1,700,600 +230,600	+16%	+$1.28M	4%	6
2017 Q2	$8.01M	Buy	1,470,000 +300,000	+26%	+$1.38M	3.35%	6
2017 Q1	$5.62M	Hold	1,170,000	–	–	2.8%	12
2016 Q4	$5.38M	Hold	1,170,000	–	–	3.17%	8
2016 Q3	$5.2M	Sell	1,170,000 -8,500	-0.7%	-$35.7K	2.72%	9
2016 Q2	$4.75M	Hold	1,178,500	–	–	3.17%	9
2016 Q1	$3.67M	Sell	1,178,500 -421,500	-26%	-$1.62M	2.29%	19
2015 Q4	$6.77M	Sell	1,600,000 -20,000	-1%	-$73.2K	2.83%	14
2015 Q3	$5.49M	Sell	1,620,000 -104,000	-6%	-$388K	2.7%	15
2015 Q2	$6.71M	Hold	1,724,000	–	–	2.67%	15
2015 Q1	$7.86M	Hold	1,724,000	–	–	3.65%	8
2014 Q4	$4.34M	Buy	1,724,000 +34,000	+2%	+$81.1K	2.2%	17
2014 Q3	$3.94M	Buy	1,690,000 +870,000	+106%	+$1.87M	3.07%	12
2014 Q2	$1.2M	Buy	820,000 +121,700	+17%	+$193K	1.03%	22
2014 Q1	$1.43M	Buy	+698,300	New	+$1.27M	1.05%	25

Other funds holding CDXS

Aberdeen Group Edinburgh, United Kingdom $61.9B AUM 29.81% 1-Year Est. Return

BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return

NCM

Nantahala Capital Management New Canaan, Connecticut $2.72B AUM 121.58% 1-Year Est. Return

Millennium Management New York $240B AUM 35.51% 1-Year Est. Return

TAM

Telemark Asset Management Boston, Massachusetts $1.08B AUM 70.88% 1-Year Est. Return

VCM

Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM

Ameriprise Minneapolis, Minnesota $432B AUM 30.22% 1-Year Est. Return

UBS Group Zurich, Switzerland $666B AUM 30.12% 1-Year Est. Return

Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return

State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return

Opaleye Management's CDXS Position: Q1 2026 in Review

Opaleye Management reduced its Codexis (CDXS) stake by 0.07% in Q1 2026, selling an estimated $6.75K and leaving 6,785,000 shares worth $11.1M. The position accounts for 1.46% of the portfolio, ranked #20.

Opaleye Management first reported a position in CDXS in Q1 2014 and has held it in 49 quarters since. The position peaked at $42.2M in Q4 2024. 134 funds tracked by Wall St. Rank hold CDXS as of Q1 2026.

Opaleye Management held 6,785,000 shares of Codexis worth $11.1M as of Q1 2026.
Opaleye Management sold 4,738 Codexis shares in Q1 2026, an estimated $6.75K.
Codexis made up 1.46% of Opaleye Management's portfolio in Q1 2026, its #20 holding.
Opaleye Management first reported a position in Codexis in Q1 2014 and has held it in 49 quarters since.
Opaleye Management's Codexis position peaked at $42.2M in Q4 2024.
134 funds tracked by Wall St. Rank held Codexis as of Q1 2026.

Based on Opaleye Management's 13F filing for Q1 2026, filed 15 May 2026.