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Opaleye Management Portfolio holdings

AUM $1.1B
1-Year Est. Return 197.64%
This Fund
S&P 500
This Quarter Est. Return
+22.36%
1 Year Est. Return
+197.64%
3 Year Est. Return
+748.31%
5 Year Est. Return
+1,163.14%
10 Year Est. Return
+87,953.74%
AUM
$386M
AUM Growth
+$36.6M
Cap. Flow
-$1.12M
Cap. Flow %
-0.29%
Top 10 Hldgs %
62.47%
Holding
49
New
11
Increased
11
Reduced
7
Closed
13

Top Buys

Rank Stock Value
1
PTE
PolarityTE, Inc. Common Stock
PTE
+$19M
2
AMAG
AMAG Pharmaceuticals
AMAG
+$9.29M
3
VRDN icon
Viridian Therapeutics
VRDN
+$8.46M
4
DNTH icon
Dianthus Therapeutics
DNTH
+$7.76M
5
XNCR icon
Xencor
XNCR
+$6.2M

Top Sells

Rank Stock Value
1
BPMC
Blueprint Medicines
BPMC
+$19.9M
2
AXGN icon
Axogen
AXGN
+$12.1M
3
ARDX icon
Ardelyx
ARDX
+$5.73M
4
ABLX
Ablynx NV
ABLX
+$4.91M
5
ACHN
Achillion Pharmaceuticals
ACHN
+$4.06M

Sector Composition

Rank Sector Weight
1 Healthcare 100%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
AXGN icon
1
Axogen
AXGN
$2.78B
$72.4M 18.73%
1,440,000
-275,000
-16% -$12.1M
LOXO
2
DELISTED
Loxo Oncology, Inc
LOXO
$30.4M 7.86%
175,000
-4,400
-2% -$661K
CDXS icon
3
Codexis
CDXS
$182M
$25.2M 6.52%
1,750,000
+49,400
+3% +$644K
KYNB
4
Kyntra Bio
KYNB
$32.4M
$22.5M 5.83%
14,400
– –
BPMC
5
DELISTED
Blueprint Medicines
BPMC
$22.2M 5.75%
350,000
-250,000
-42% -$19.9M
PTE
6
DELISTED
PolarityTE, Inc. Common Stock
PTE
$18.8M 4.87%
+32,000
New +$19M
DCPH
7
DELISTED
Deciphera Pharmaceuticals, Inc. Common Stock
DCPH
$16.5M 4.28%
420,000
+55,000
+15% +$1.62M
VKTX icon
8
Viking Therapeutics
VKTX
$3.95B
$11.4M 2.95%
1,200,000
+99,200
+9% +$660K
SBBP
9
DELISTED
Strongbridge Biopharma plc.
SBBP
$11M 2.84%
1,830,000
+240,000
+15% +$1.76M
AGIO icon
10
Agios Pharmaceuticals
AGIO
$2.05B
$10.9M 2.83%
130,000
– –
FENC icon
11
Fennec Pharmaceuticals
FENC
$413M
$9.87M 2.55%
945,000
+72,000
+8% +$854K
CBAY
12
DELISTED
Cymabay Therapeutics
CBAY
$9.36M 2.42%
697,500
+32,500
+5% +$407K
TGTX icon
13
TG Therapeutics
TGTX
$8.53B
$8.22M 2.13%
625,000
+350,800
+128% +$4.82M
AMAG
14
DELISTED
AMAG Pharmaceuticals
AMAG
$8.19M 2.12%
+420,000
New +$9.29M
VRDN icon
15
Viridian Therapeutics
VRDN
$2.71B
$7.69M 1.99%
+80,000
New +$8.46M
OCUL icon
16
Ocular Therapeutix
OCUL
$2.38B
$7.5M 1.94%
1,111,000
– –
DNTH icon
17
Dianthus Therapeutics
DNTH
$6.24B
$7.42M 1.92%
+34,375
New +$7.76M
BOLD
18
DELISTED
Audentes Therapeutics, Inc
BOLD
$7.26M 1.88%
190,000
– –
SGMO
19
DELISTED
SANGAMO THERAPEUTICS INC
SGMO
$7.17M 1.86%
505,000
-30,000
-6% -$498K
XOMA
20
DELISTED
Xoma
XOMA
$6.68M 1.73%
320,200
– –
XNCR icon
21
Xencor
XNCR
$2.15B
$6.66M 1.72%
+180,000
New +$6.2M
CORI
22
DELISTED
Corium International, Inc.
CORI
$6.41M 1.66%
800,000
-265,000
-25% -$2.51M
CDTX
23
DELISTED
Cidara Therapeutics
CDTX
$6.24M 1.62%
+60,000
New +$5.66M
RARE icon
24
Ultragenyx Pharmaceutical
RARE
$2.59B
$6.15M 1.59%
80,000
– –
PTCT icon
25
PTC Therapeutics
PTCT
$5.99B
$6.07M 1.57%
180,000
+35,000
+24% +$1.09M
1
2

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Opaleye Management's Q2 2018 Portfolio in Review

As of Q2 2018, Opaleye Management held 49 positions worth $386M, up 10% from $350M the previous quarter. Its ten largest holdings account for 62% of the portfolio.

Opaleye Management's Q2 2018 filing shows 11 new, 11 increased, 7 reduced and 13 closed positions. Its largest new stake was PolarityTE, Inc. Common Stock: 32,000 shares worth $18.8M. The largest sale was Blueprint Medicines, an estimated $19.9M.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, up from 94% a quarter earlier.

  • Opaleye Management's largest Q2 2018 buy was PolarityTE, Inc. Common Stock: 32,000 shares worth $18.8M.
  • Opaleye Management added most to TG Therapeutics in Q2 2018, an estimated $4.82M increase.
  • Opaleye Management's biggest Q2 2018 reduction was Blueprint Medicines, cutting an estimated $19.9M.
  • Opaleye Management fully exited Ardelyx in Q2 2018, selling an estimated $5.73M.
  • Opaleye Management's ten largest holdings make up 62% of its $386M portfolio in Q2 2018.
  • Opaleye Management opened 11 new positions and closed 13 in Q2 2018.
  • Opaleye Management's portfolio value rose 10% quarter-over-quarter to $386M.

Based on Opaleye Management's 13F filing for Q2 2018, filed 14 Aug 2018.