Jim Simons
PRME icon

Jim Simons’s Prime Medicine PRME Stock Holding History

Jim Simons’s Portfolio PRME Stock Details PRME Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$2.58M Sell
741,039
-408,120
-36% -$1.55M ﹤0.01% 1742
2025
Q4 		$3.99M Buy
1,149,159
+14,489
+1% +$64.4K 0.01% 1439
2025
Q3 		$6.29M Buy
1,134,670
+911,270
+408% +$3.7M 0.01% 1358
2025
Q2 		$552K Sell
223,400
-224,200
-50% -$346K ﹤0.01% 2785
2025
Q1 		$891K Buy
+447,600
New +$1.14M ﹤0.01% 2486
2024
Q4 		– Sell
-20,000
Closed -$77.4K – 3836
2024
Q3 		$77.4K Buy
+20,000
New +$92.6K ﹤0.01% 3296
2024
Q2 		– Sell
-362,400
Closed -$2.54M – 3870
2024
Q1 		$2.54M Buy
362,400
+309,108
+580% +$2.34M ﹤0.01% 1870
2023
Q4 		$472K Buy
+53,292
New +$411K ﹤0.01% 2808

Other funds holding PRME

AI
Alphabet Inc Mountain View, California $99.1B AUM 124.46% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
State Street
State Street Boston, Massachusetts $3.37T AUM 44.26% 1-Year Est. Return
AIM
ARK Investment Management St. Petersburg, Florida $12.9B AUM 64.92% 1-Year Est. Return
T. Rowe Price Investment Management
T. Rowe Price Investment Management Baltimore, Maryland $145B AUM 22.78% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
Balyasny Asset Management
Balyasny Asset Management Chicago, Illinois $77.1B AUM 42.89% 1-Year Est. Return
CC
Casdin Capital New York $1.32B AUM 76.62% 1-Year Est. Return
WP
Woodline Partners San Francisco, California $26.4B AUM 44.85% 1-Year Est. Return
Sumitomo Mitsui Trust Group
Sumitomo Mitsui Trust Group Minato-Ku, Tokyo, Japan $175B AUM 40.63% 1-Year Est. Return

Jim Simons's PRME Position: Q1 2026 in Review

Jim Simons reduced its Prime Medicine (PRME) stake by 36% in Q1 2026, selling an estimated $1.55M and leaving 741,039 shares worth $2.58M. The position accounts for ﹤0.01% of the portfolio, ranked #1742.

Jim Simons first reported a position in PRME in Q4 2023 and has held it in 8 quarters since. The position peaked at $6.29M in Q3 2025. 192 funds tracked by Wall St. Rank hold PRME as of Q1 2026.

  • Jim Simons held 741,039 shares of Prime Medicine worth $2.58M as of Q1 2026.
  • Jim Simons sold 408,120 Prime Medicine shares in Q1 2026, an estimated $1.55M.
  • Prime Medicine made up ﹤0.01% of Jim Simons's portfolio in Q1 2026, its #1742 holding.
  • Jim Simons first reported a position in Prime Medicine in Q4 2023 and has held it in 8 quarters since.
  • Jim Simons's Prime Medicine position peaked at $6.29M in Q3 2025.
  • 192 funds tracked by Wall St. Rank held Prime Medicine as of Q1 2026.

Based on Renaissance Technologies's 13F filing for Q1 2026, filed 14 May 2026.