Jane Street’s Upstream Bio Inc UPB Stock Holding History

Jane Street’s Portfolio UPB Stock Details UPB Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2025 Q4	–	Sell	-20,500	Closed	-$386K	–	12733
2025 Q3	$386K	Buy	+20,500	New	+$319K	﹤0.01%	8393

Other funds holding UPB

Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return

OrbiMed New York $5.05B AUM 125.28% 1-Year Est. Return

BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return

Decheng Capital Menlo Park, California $661M AUM 299.97% 1-Year Est. Return

Enavate Sciences Menlo Park, California $352M AUM 220.14% 1-Year Est. Return

VCM

Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM

YIH

Y-Intercept (HK) Hong Kong $5.05B AUM 17.89% 1-Year Est. Return

Federated Hermes Pittsburgh, Pennsylvania $61.5B AUM 30.7% 1-Year Est. Return

Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return

Millennium Management New York $240B AUM 35.51% 1-Year Est. Return

Jane Street's UPB Position: Q1 2025 in Review

Jane Street sold out of Upstream Bio Inc (UPB) in Q1 2025, closing a stake of 45,549 shares — an estimated $749K sold.

Jane Street first reported a position in UPB in Q4 2024 and held it in 1 quarter. The position peaked at $749K in Q4 2024. 79 funds tracked by Wall St. Rank hold UPB as of Q1 2025.

Jane Street reported no remaining Upstream Bio Inc position as of Q1 2025 after selling out during the quarter.
Jane Street sold 45,549 Upstream Bio Inc shares in Q1 2025, an estimated $749K.
Jane Street first reported a position in Upstream Bio Inc in Q4 2024 and held it in 1 quarter.
Jane Street's Upstream Bio Inc position peaked at $749K in Q4 2024.
79 funds tracked by Wall St. Rank held Upstream Bio Inc as of Q1 2025.

Based on Jane Street's 13F filing for Q1 2025, filed 14 May 2025.