Jane Street
MREO

Jane Street’s Mereo BioPharma MREO Stock Holding History

Jane Street’s Portfolio MREO Stock Details MREO Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$246K Buy
774,944
+634,971
+454% +$190K ﹤0.01% 9638
2026
Q1 		$46.2K Sell
139,973
-216,031
-61% -$92.7K ﹤0.01% 11003
2025
Q4 		$148K Sell
356,004
-96,358
-21% -$183K ﹤0.01% 9939
2025
Q3 		$932K Buy
452,362
+204,921
+83% +$378K ﹤0.01% 6449
2025
Q2 		$671K Buy
247,441
+102,638
+71% +$248K ﹤0.01% 6386
2025
Q1 		$326K Buy
144,803
+24,525
+20% +$69.4K ﹤0.01% 7661
2024
Q4 		$421K Sell
120,278
-94,357
-44% -$371K ﹤0.01% 7146
2024
Q3 		$882K Buy
214,635
+130,042
+154% +$538K ﹤0.01% 6131
2024
Q2 		$305K Sell
84,593
-2,280
-3% -$7.38K ﹤0.01% 7781
2024
Q1 		$287K Buy
+86,873
New +$294K ﹤0.01% 7636
2023
Q4 		– Sell
-17,285
Closed -$22.3K – 9577
2023
Q3 		$22.3K Sell
17,285
-1,461
-8% -$1.94K ﹤0.01% 8290
2023
Q2 		$24.7K Sell
18,746
-72,347
-79% -$83.9K ﹤0.01% 8334
2023
Q1 		$64.4K Sell
91,093
-101,869
-53% -$91.7K ﹤0.01% 8377
2022
Q4 		$145K Buy
192,962
+19,176
+11% +$15.7K ﹤0.01% 7885
2022
Q3 		$150K Buy
173,786
+151,762
+689% +$186K ﹤0.01% 8399
2022
Q2 		$25K Buy
+22,024
New +$17.1K ﹤0.01% 9109
2021
Q2 		– Sell
-47,219
Closed -$159K – 10181
2021
Q1 		$159K Buy
47,219
+24,181
+105% +$85.5K ﹤0.01% 8428
2020
Q4 		$82K Buy
+23,038
New +$57.7K ﹤0.01% 7251

Other funds holding MREO

RCMNY
Rubric Capital Management (New York) New York $10.9B AUM 70.31% 1-Year Est. Return
6CM
683 Capital Management New York $2.04B AUM 94.26% 1-Year Est. Return
Bank of America
Bank of America Charlotte, North Carolina $1.55T AUM 33.47% 1-Year Est. Return
DCM
Defilade Capital Management Emeryville, California $747M AUM
NM
Newtyn Management New York $801M AUM 23.14% 1-Year Est. Return
TC
Tejara Capital London, United Kingdom $243M AUM 9.84% 1-Year Est. Return
UBS Group
UBS Group Zurich, Switzerland $786B AUM 40.34% 1-Year Est. Return
Two Sigma Investments
Two Sigma Investments New York $138B AUM 41.87% 1-Year Est. Return
EC
EcoR1 Capital San Francisco, California $2.06B AUM 215.32% 1-Year Est. Return
II
Ishara Investments Los Angeles, California $136M AUM

Jane Street's MREO Position: Q2 2026 in Review

Jane Street increased its Mereo BioPharma (MREO) stake by 454% in Q2 2026, buying an estimated $190K and bringing the position to 774,944 shares worth $246K. The position accounts for ﹤0.01% of the portfolio, ranked #9638.

Jane Street first reported a position in MREO in Q4 2020 and has held it in 18 quarters since. The position peaked at $932K in Q3 2025. 61 funds tracked by Wall St. Rank hold MREO as of Q2 2026.

  • Jane Street held 774,944 shares of Mereo BioPharma worth $246K as of Q2 2026.
  • Jane Street bought 634,971 Mereo BioPharma shares in Q2 2026, an estimated $190K.
  • Mereo BioPharma made up ﹤0.01% of Jane Street's portfolio in Q2 2026, its #9638 holding.
  • Jane Street first reported a position in Mereo BioPharma in Q4 2020 and has held it in 18 quarters since.
  • Jane Street's Mereo BioPharma position peaked at $932K in Q3 2025.
  • 61 funds tracked by Wall St. Rank held Mereo BioPharma as of Q2 2026.

Based on Jane Street's 13F filing for Q2 2026, filed 14 Aug 2026.