Two Sigma Investments
MREO

Two Sigma Investments’s Mereo BioPharma MREO Stock Holding History

Two Sigma Investments’s Portfolio MREO Stock Details MREO Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$62K Sell
187,839
-337,286
-64% -$145K ﹤0.01% 4436
2025
Q4 		$219K Sell
525,125
-562,971
-52% -$1.07M ﹤0.01% 3734
2025
Q3 		$2.24M Buy
1,088,096
+428,938
+65% +$791K ﹤0.01% 2047
2025
Q2 		$1.79M Buy
659,158
+413,952
+169% +$999K ﹤0.01% 1923
2025
Q1 		$552K Buy
245,206
+176,471
+257% +$499K ﹤0.01% 2484
2024
Q4 		$241K Sell
68,735
-65,578
-49% -$258K ﹤0.01% 2813
2024
Q3 		$552K Sell
134,313
-67,463
-33% -$279K ﹤0.01% 2422
2024
Q2 		$726K Sell
201,776
-149,953
-43% -$486K ﹤0.01% 2169
2024
Q1 		$1.16M Buy
351,729
+40,669
+13% +$138K ﹤0.01% 1860
2023
Q4 		$719K Buy
311,060
+168,458
+118% +$322K ﹤0.01% 2266
2023
Q3 		$184K Sell
142,602
-55,157
-28% -$73.2K ﹤0.01% 2654
2023
Q2 		$261K Buy
+197,759
New +$229K ﹤0.01% 2557

Other funds holding MREO

RCMNY
Rubric Capital Management (New York) New York $9.44B AUM 68.42% 1-Year Est. Return
EC
EcoR1 Capital San Francisco, California $2.36B AUM 204.53% 1-Year Est. Return
6CM
683 Capital Management New York $1.92B AUM 85.52% 1-Year Est. Return
Bank of America
Bank of America Charlotte, North Carolina $1.37T AUM 24.88% 1-Year Est. Return
DCM
Defilade Capital Management Emeryville, California $712M AUM
NM
Newtyn Management New York $936M AUM 27.23% 1-Year Est. Return
Millennium Management
Millennium Management New York $240B AUM 35.51% 1-Year Est. Return
TC
Tejara Capital London, United Kingdom $303M AUM 5.43% 1-Year Est. Return
UBS Group
UBS Group Zurich, Switzerland $666B AUM 30.12% 1-Year Est. Return
WANY
Wealthspire Advisors (New York) New York $12.7B AUM 17.31% 1-Year Est. Return

Two Sigma Investments's MREO Position: Q1 2026 in Review

Two Sigma Investments reduced its Mereo BioPharma (MREO) stake by 64% in Q1 2026, selling an estimated $145K and leaving 187,839 shares worth $62K. The position accounts for ﹤0.01% of the portfolio, ranked #4436.

Two Sigma Investments first reported a position in MREO in Q2 2023 and has held it in 12 quarters since. The position peaked at $2.24M in Q3 2025. 63 funds tracked by Wall St. Rank hold MREO as of Q1 2026.

  • Two Sigma Investments held 187,839 shares of Mereo BioPharma worth $62K as of Q1 2026.
  • Two Sigma Investments sold 337,286 Mereo BioPharma shares in Q1 2026, an estimated $145K.
  • Mereo BioPharma made up ﹤0.01% of Two Sigma Investments's portfolio in Q1 2026, its #4436 holding.
  • Two Sigma Investments first reported a position in Mereo BioPharma in Q2 2023 and has held it in 12 quarters since.
  • Two Sigma Investments's Mereo BioPharma position peaked at $2.24M in Q3 2025.
  • 63 funds tracked by Wall St. Rank held Mereo BioPharma as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.