Israel Englander’s Upstream Bio Inc UPB Stock Holding History

Israel Englander’s Portfolio UPB Stock Details UPB Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q2	$7.91M	Buy	1,143,775 +206,452	+22%	+$1.73M	﹤0.01%	2545
2026 Q1	$8.44M	Buy	937,323 +420,059	+81%	+$7.56M	﹤0.01%	2345
2025 Q4	$14M	Buy	517,264 +477,151	+1,190%	+$11.9M	0.01%	1910
2025 Q3	$755K	Buy	+40,113	New	+$623K	﹤0.01%	4826
2025 Q2	–	Sell	-61,796	Closed	-$378K	–	6445
2025 Q1	$378K	Buy	+61,796	New	+$590K	﹤0.01%	4973

Other funds holding UPB

Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return

OrbiMed New York $5.4B AUM 163.13% 1-Year Est. Return

Norges Bank Oslo, Norway $1T AUM

BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return

Decheng Capital Menlo Park, California $732M AUM 275.56% 1-Year Est. Return

Enavate Sciences Menlo Park, California $345M AUM 134.64% 1-Year Est. Return

Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM

D.E. Shaw & Co New York $210B AUM 57.28% 1-Year Est. Return

JP Morgan Chase New York $1.81T AUM 41.13% 1-Year Est. Return

Qube Research & Technologies (QRT) London, United Kingdom $108B AUM 37.29% 1-Year Est. Return

Israel Englander's UPB Position: Q2 2026 in Review

Israel Englander increased its Upstream Bio Inc (UPB) stake by 22% in Q2 2026, buying an estimated $1.73M and bringing the position to 1,143,775 shares worth $7.91M. The position accounts for ﹤0.01% of the portfolio, ranked #2545.

Israel Englander first reported a position in UPB in Q1 2025 and has held it in 5 quarters since. The position peaked at $14M in Q4 2025. 149 funds tracked by Wall St. Rank hold UPB as of Q2 2026.

Israel Englander held 1,143,775 shares of Upstream Bio Inc worth $7.91M as of Q2 2026.
Israel Englander bought 206,452 Upstream Bio Inc shares in Q2 2026, an estimated $1.73M.
Upstream Bio Inc made up ﹤0.01% of Israel Englander's portfolio in Q2 2026, its #2545 holding.
Israel Englander first reported a position in Upstream Bio Inc in Q1 2025 and has held it in 5 quarters since.
Israel Englander's Upstream Bio Inc position peaked at $14M in Q4 2025.
149 funds tracked by Wall St. Rank held Upstream Bio Inc as of Q2 2026.

Based on Millennium Management's 13F filing for Q2 2026, filed 14 Aug 2026.