DS
UPB

David Shaw’s Upstream Bio Inc UPB Stock Holding History

David Shaw’s Portfolio UPB Stock Details UPB Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$7.17M Buy
1,036,044
+215,564
+26% +$1.81M ﹤0.01% 2120
2026
Q1 		$7.38M Buy
820,480
+793,389
+2,929% +$14.3M ﹤0.01% 1869
2025
Q4 		$736K Buy
+27,091
New +$674K ﹤0.01% 3727

Other funds holding UPB

Fidelity Investments
Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return
O
OrbiMed New York $5.4B AUM 163.13% 1-Year Est. Return
Norges Bank
Norges Bank Oslo, Norway $1T AUM
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
DC
Decheng Capital Menlo Park, California $732M AUM 275.56% 1-Year Est. Return
ES
Enavate Sciences Menlo Park, California $345M AUM 134.64% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
Millennium Management
Millennium Management New York $276B AUM 44.8% 1-Year Est. Return
JP Morgan Chase
JP Morgan Chase New York $1.81T AUM 41.13% 1-Year Est. Return
Qube Research & Technologies (QRT)
Qube Research & Technologies (QRT) London, United Kingdom $108B AUM 37.29% 1-Year Est. Return

David Shaw's UPB Position: Q2 2026 in Review

David Shaw increased its Upstream Bio Inc (UPB) stake by 26% in Q2 2026, buying an estimated $1.81M and bringing the position to 1,036,044 shares worth $7.17M. The position accounts for ﹤0.01% of the portfolio, ranked #2120.

David Shaw first reported a position in UPB in Q4 2025 and has held it in 3 quarters since. The position peaked at $7.38M in Q1 2026. 150 funds tracked by Wall St. Rank hold UPB as of Q2 2026.

  • David Shaw held 1,036,044 shares of Upstream Bio Inc worth $7.17M as of Q2 2026.
  • David Shaw bought 215,564 Upstream Bio Inc shares in Q2 2026, an estimated $1.81M.
  • Upstream Bio Inc made up ﹤0.01% of David Shaw's portfolio in Q2 2026, its #2120 holding.
  • David Shaw first reported a position in Upstream Bio Inc in Q4 2025 and has held it in 3 quarters since.
  • David Shaw's Upstream Bio Inc position peaked at $7.38M in Q1 2026.
  • 150 funds tracked by Wall St. Rank held Upstream Bio Inc as of Q2 2026.

Based on D.E. Shaw & Co's 13F filing for Q2 2026, filed 14 Aug 2026.