D.E. Shaw & Co
ZYME icon

D.E. Shaw & Co’s Zymeworks ZYME Stock Holding History

D.E. Shaw & Co’s Portfolio ZYME Stock Details ZYME Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$5.9M Buy
235,621
+11,835
+5% +$280K ﹤0.01% 2057
2025
Q4 		$5.89M Buy
223,786
+96,863
+76% +$2.11M ﹤0.01% 2175
2025
Q3 		$2.17M Sell
126,923
-128,368
-50% -$1.84M ﹤0.01% 2912
2025
Q2 		$3.2M Buy
255,291
+192,192
+305% +$2.29M ﹤0.01% 2377
2025
Q1 		$752K Buy
63,099
+42,259
+203% +$576K ﹤0.01% 3268
2024
Q4 		$305K Sell
20,840
-942
-4% -$13.2K ﹤0.01% 3879
2024
Q3 		$273K Sell
21,782
-21,974
-50% -$239K ﹤0.01% 4020
2024
Q2 		$372K Buy
43,756
+16,643
+61% +$148K ﹤0.01% 3786
2024
Q1 		$285K Buy
+27,113
New +$301K ﹤0.01% 3753
2023
Q4 		– Sell
-65,068
Closed -$413K – 4673
2023
Q3 		$413K Buy
65,068
+15,714
+32% +$116K ﹤0.01% 3498
2023
Q2 		$426K Buy
+49,354
New +$442K ﹤0.01% 3481
2023
Q1 		– Sell
-369,187
Closed -$2.9M – 4929
2022
Q4 		$2.9M Buy
369,187
+280,710
+317% +$1.97M ﹤0.01% 2618
2022
Q3 		$544K Buy
88,477
+66,567
+304% +$401K ﹤0.01% 3992
2022
Q2 		$116K Sell
21,910
-415,581
-95% -$2.51M ﹤0.01% 4699
2022
Q1 		$2.87M Buy
437,491
+405,408
+1,264% +$3.61M ﹤0.01% 2947
2021
Q4 		$526K Buy
32,083
+23,836
+289% +$497K ﹤0.01% 4375
2021
Q3 		$239K Sell
8,247
-537
-6% -$17.9K ﹤0.01% 4485
2021
Q2 		$305K Sell
8,784
-10,558
-55% -$335K ﹤0.01% 4271
2021
Q1 		$611K Sell
19,342
-48,944
-72% -$1.99M ﹤0.01% 3408
2020
Q4 		$3.23M Sell
68,286
-58,538
-46% -$2.72M ﹤0.01% 2213
2020
Q3 		$5.91M Sell
126,824
-136,862
-52% -$4.7M 0.01% 1578
2020
Q2 		$9.51M Sell
263,686
-2,823
-1% -$104K 0.01% 1212
2020
Q1 		$9.45M Sell
266,509
-275,161
-51% -$11.3M 0.01% 1030
2019
Q4 		$24.6M Buy
541,670
+144,961
+37% +$5.27M 0.03% 706
2019
Q3 		$9.84M Buy
396,709
+136,528
+52% +$3.42M 0.01% 1173
2019
Q2 		$5.72M Buy
+260,181
New +$4.78M 0.01% 1499
2018
Q3 		– Sell
-26,621
Closed -$393K – 4020
2018
Q2 		$393K Buy
+26,621
New +$412K ﹤0.01% 3246

Other funds holding ZYME

EC
EcoR1 Capital San Francisco, California $2.36B AUM 204.53% 1-Year Est. Return
RCMNY
Rubric Capital Management (New York) New York $9.44B AUM 68.42% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
BI
BVF Inc San Francisco, California $3.14B AUM 249.53% 1-Year Est. Return
PA
Perceptive Advisors New York $5.12B AUM 314.02% 1-Year Est. Return
Morgan Stanley
Morgan Stanley New York $1.66T AUM 25.57% 1-Year Est. Return
BNP Paribas Asset Management
BNP Paribas Asset Management Paris, France $86.1B AUM 29.11% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
Citadel Advisors
Citadel Advisors Miami, Florida $618B AUM 30.34% 1-Year Est. Return
Dimensional Fund Advisors
Dimensional Fund Advisors Austin, Texas $481B AUM 30.42% 1-Year Est. Return

D.E. Shaw & Co's ZYME Position: Q1 2026 in Review

D.E. Shaw & Co increased its Zymeworks (ZYME) stake by 5.3% in Q1 2026, buying an estimated $280K and bringing the position to 235,621 shares worth $5.9M. The position accounts for ﹤0.01% of the portfolio, ranked #2057.

D.E. Shaw & Co first reported a position in ZYME in Q2 2018 and has held it in 27 quarters since. The position peaked at $24.6M in Q4 2019. 211 funds tracked by Wall St. Rank hold ZYME as of Q1 2026.

  • D.E. Shaw & Co held 235,621 shares of Zymeworks worth $5.9M as of Q1 2026.
  • D.E. Shaw & Co bought 11,835 Zymeworks shares in Q1 2026, an estimated $280K.
  • Zymeworks made up ﹤0.01% of D.E. Shaw & Co's portfolio in Q1 2026, its #2057 holding.
  • D.E. Shaw & Co first reported a position in Zymeworks in Q2 2018 and has held it in 27 quarters since.
  • D.E. Shaw & Co's Zymeworks position peaked at $24.6M in Q4 2019.
  • 211 funds tracked by Wall St. Rank held Zymeworks as of Q1 2026.

Based on D.E. Shaw & Co's 13F filing for Q1 2026, filed 15 May 2026.