D.E. Shaw & Co
GH icon

D.E. Shaw & Co’s Guardant Health GH Stock Holding History

D.E. Shaw & Co’s Portfolio GH Stock Details GH Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$39.5M Sell
427,475
-195,582
-31% -$19.6M 0.02% 764
2025
Q4 		$63.6M Buy
623,057
+589,710
+1,768% +$52.8M 0.03% 594
2025
Q3 		$2.08M Buy
+33,347
New +$1.81M ﹤0.01% 2951
2024
Q2 		– Sell
-109,943
Closed -$2.56M – 4611
2024
Q1 		$2.27M Sell
109,943
-26,086
-19% -$559K ﹤0.01% 2539
2023
Q4 		$3.68M Sell
136,029
-90,063
-40% -$2.36M ﹤0.01% 2162
2023
Q3 		$6.7M Buy
+226,092
New +$7.95M 0.01% 1572
2023
Q2 		– Sell
-490,671
Closed -$14.1M – 4349
2023
Q1 		$11.5M Buy
+490,671
New +$14M 0.01% 1254
2022
Q3 		– Sell
-9,400
Closed -$379K – 5302
2022
Q2 		$379K Buy
+9,400
New +$466K ﹤0.01% 4254
2021
Q4 		– Sell
-71,604
Closed -$8.95M – 5510
2021
Q3 		$8.95M Sell
71,604
-157,128
-69% -$18.7M 0.01% 1600
2021
Q2 		$28.4M Sell
228,732
-39,970
-15% -$5.38M 0.02% 824
2021
Q1 		$41M Buy
268,702
+224,549
+509% +$33.9M 0.04% 580
2020
Q4 		$5.69M Buy
44,153
+33,248
+305% +$3.83M 0.01% 1773
2020
Q3 		$1.22M Buy
+10,905
New +$998K ﹤0.01% 2732
2020
Q2 		– Sell
-10,587
Closed -$737K – 4073
2020
Q1 		$737K Buy
+10,587
New +$812K ﹤0.01% 2970

Other funds holding GH

BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
T. Rowe Price Associates
T. Rowe Price Associates Baltimore, Maryland $865B AUM 30.76% 1-Year Est. Return
VPM
Vanguard Portfolio Management Malvern, Pennsylvania $1.91T AUM
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
Invesco
Invesco Atlanta, Georgia $1.02T AUM 30.18% 1-Year Est. Return
Goldman Sachs
Goldman Sachs New York $871B AUM 31.28% 1-Year Est. Return
Two Sigma Investments
Two Sigma Investments New York $124B AUM 33.93% 1-Year Est. Return
Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
Baillie Gifford & Co
Baillie Gifford & Co Edinburgh, United Kingdom $97.9B AUM 20.73% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return

D.E. Shaw & Co's GH Position: Q1 2026 in Review

D.E. Shaw & Co reduced its Guardant Health (GH) stake by 31% in Q1 2026, selling an estimated $19.6M and leaving 427,475 shares worth $39.5M. The position accounts for 0.02% of the portfolio, ranked #764.

D.E. Shaw & Co first reported a position in GH in Q1 2020 and has held it in 14 quarters since. The position peaked at $63.6M in Q4 2025. 481 funds tracked by Wall St. Rank hold GH as of Q1 2026.

  • D.E. Shaw & Co held 427,475 shares of Guardant Health worth $39.5M as of Q1 2026.
  • D.E. Shaw & Co sold 195,582 Guardant Health shares in Q1 2026, an estimated $19.6M.
  • Guardant Health made up 0.02% of D.E. Shaw & Co's portfolio in Q1 2026, its #764 holding.
  • D.E. Shaw & Co first reported a position in Guardant Health in Q1 2020 and has held it in 14 quarters since.
  • D.E. Shaw & Co's Guardant Health position peaked at $63.6M in Q4 2025.
  • 481 funds tracked by Wall St. Rank held Guardant Health as of Q1 2026.

Based on D.E. Shaw & Co's 13F filing for Q1 2026, filed 15 May 2026.