D.E. Shaw & Co’s Arrowhead Research ARWR Stock Holding History

D.E. Shaw & Co’s Portfolio ARWR Stock Details ARWR Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2025 Q3	–	Sell	-58,500	Closed	-$924K	–	4547
2025 Q2	$924K	Buy	58,500 +36,900	+171%	+$529K	﹤0.01%	3291
2025 Q1	$275K	Buy	+21,600	New	+$393K	﹤0.01%	3800
2024 Q4	–	Sell	-11,100	Closed	-$215K	–	4397
2024 Q3	$215K	Buy	+11,100	New	+$271K	﹤0.01%	4121
2022 Q1	–	Sell	-10,000	Closed	-$663K	–	5510
2021 Q4	$663K	Hold	10,000	–	–	﹤0.01%	4230
2021 Q3	$624K	Hold	10,000	–	–	﹤0.01%	3943
2021 Q2	$828K	Hold	10,000	–	–	﹤0.01%	3695
2021 Q1	$663K	Hold	10,000	–	–	﹤0.01%	3371
2020 Q4	$767K	Hold	10,000	–	–	﹤0.01%	3188
2020 Q3	$431K	Sell	10,000 -24,900	-71%	-$1.07M	﹤0.01%	3295
2020 Q2	$1.51M	Buy	34,900 +14,900	+75%	+$526K	﹤0.01%	2628
2020 Q1	$575K	Hold	20,000	–	–	﹤0.01%	3137
2019 Q4	$1.27M	Buy	+20,000	New	+$992K	﹤0.01%	2810
2014 Q2	–	Sell	-33,500	Closed	-$550K	–	4167
2014 Q1	$550K	Buy	+33,500	New	+$588K	﹤0.01%	3517

Other funds holding ARWR

BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return

ACA

Avoro Capital Advisors New York $10.2B AUM 149.19% 1-Year Est. Return

Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return

VPM

Vanguard Portfolio Management Malvern, Pennsylvania $1.91T AUM

State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return

VCM

Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM

Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return

FAM

Fred Alger Management New York $22.8B AUM 64.63% 1-Year Est. Return

Invesco Atlanta, Georgia $1.02T AUM 30.18% 1-Year Est. Return

VPC

Vestal Point Capital New York $3.58B AUM 189.12% 1-Year Est. Return

D.E. Shaw & Co's ARWR Position: Q1 2026 in Review

D.E. Shaw & Co increased its Arrowhead Research (ARWR) stake by 710% in Q1 2026, buying an estimated $65.7M and bringing the position to 1,183,838 shares worth $74.2M. The position accounts for 0.04% of the portfolio, ranked #497.

D.E. Shaw & Co first reported a position in ARWR in Q1 2014 and has held it in 36 quarters since. 436 funds tracked by Wall St. Rank hold ARWR as of Q1 2026.

D.E. Shaw & Co held 1,183,838 shares of Arrowhead Research worth $74.2M as of Q1 2026.
D.E. Shaw & Co bought 1,037,774 Arrowhead Research shares in Q1 2026, an estimated $65.7M.
Arrowhead Research made up 0.04% of D.E. Shaw & Co's portfolio in Q1 2026, its #497 holding.
D.E. Shaw & Co first reported a position in Arrowhead Research in Q1 2014 and has held it in 36 quarters since.
436 funds tracked by Wall St. Rank held Arrowhead Research as of Q1 2026.

Based on D.E. Shaw & Co's 13F filing for Q1 2026, filed 15 May 2026.