Arrowhead Research
ARWR
304 hedge funds and large institutions have $3.83B invested in Arrowhead Research in 2025 Q3 according to their latest regulatory filings, with 66 funds opening new positions, 101 increasing their positions, 83 reducing their positions, and 41 closing their positions.
274% more call options, than puts
Call options by funds: $36.5M | Put options by funds: $9.75M
133% more funds holding in top 10
Funds holding in top 10: 3 → 7 (+4)
129% more capital invested
Capital invested by funds: $1.67B → $3.83B (+$2.16B)
61% more first-time investments, than exits
New positions opened: 66 | Existing positions closed: 41
22% more repeat investments, than reductions
Existing positions increased: 101 | Existing positions reduced: 83
8% more funds holding
Funds holding: 282 → 304 (+22)
3.65% more ownership
Funds ownership: 76.65% → 80.3% (+3.7%)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
DCM
Driehaus Capital Management
Chicago,
Illinois
|
+$46.2M |
| 2 |
Arrowstreet Capital
Boston,
Massachusetts
|
+$44.4M |
| 3 |
DM
Deerfield Management
New York
|
+$21.8M |
| 4 |
Janus Henderson Group
London,
United Kingdom
|
+$20.3M |
| 5 |
BlackRock
New York
|
+$17.6M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
UBS AM
Chicago,
Illinois
|
-$20.3M |
| 2 |
Marshall Wace
London,
United Kingdom
|
-$15.8M |
| 3 |
UBS Group
Zurich,
Switzerland
|
-$15M |
| 4 |
T. Rowe Price Investment Management
Baltimore,
Maryland
|
-$13M |
| 5 |
Aberdeen Group
Edinburgh,
United Kingdom
|
-$9.66M |
ARWR Hedge Fund Activity: Q3 2025 in Review
304 of the 7,620 institutional investors tracked by Wall St. Rank reported a position in Arrowhead Research (ARWR) for Q3 2025, worth a combined $3.83B — up 129% from $1.67B a quarter earlier.
Buyers outnumbered sellers: 66 funds opened new ARWR positions and 41 closed out — a net gain of 25 holders — while 101 added to existing stakes and 83 trimmed.
The largest buyer was Driehaus Capital Management, opening a new position worth an estimated $46.2M. The largest seller was UBS AM, cutting an estimated $20.3M.
- 304 institutional investors held Arrowhead Research (ARWR) as of Q3 2025, up from 282 in Q2 2025.
- Funds reported $3.83B of Arrowhead Research stock for Q3 2025, up 129% quarter-over-quarter.
- 66 funds opened new Arrowhead Research positions in Q3 2025 and 41 closed out, a net change of +25 holders.
- The largest Arrowhead Research buyer in Q3 2025 was Driehaus Capital Management, an estimated $46.2M added.
- The largest Arrowhead Research seller in Q3 2025 was UBS AM, an estimated $20.3M sold.
Based on aggregated 13F filings for Q3 2025.