Arrowhead Research
ARWR
401 hedge funds and large institutions have $7.71B invested in Arrowhead Research in 2025 Q4 according to their latest regulatory filings, with 127 funds opening new positions, 125 increasing their positions, 110 reducing their positions, and 28 closing their positions.
354% more first-time investments, than exits
New positions opened: 127 | Existing positions closed: 28
281% more call options, than puts
Call options by funds: $148M | Put options by funds: $38.8M
101% more capital invested
Capital invested by funds: $3.83B → $7.71B (+$3.88B)
32% more funds holding
Funds holding: 304 → 401 (+97)
14% more funds holding in top 10
Funds holding in top 10: 7 → 8 (+1)
14% more repeat investments, than reductions
Existing positions increased: 125 | Existing positions reduced: 110
5.12% more ownership
Funds ownership: 80.3% → 85.42% (+5.1%)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
FAM
Fred Alger Management
New York
|
+$74.8M |
| 2 |
BlackRock
New York
|
+$53.6M |
| 3 |
VPC
Vestal Point Capital
New York
|
+$44.1M |
| 4 |
DM
Deerfield Management
New York
|
+$41.2M |
| 5 |
Fidelity Investments
Boston,
Massachusetts
|
+$37.3M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
SPC
Slate Path Capital
New York
|
-$120M |
| 2 |
Marshall Wace
London,
United Kingdom
|
-$64.4M |
| 3 |
SL
Siren LLC
Greenwich,
Connecticut
|
-$57.3M |
| 4 |
Vanguard Group
Malvern,
Pennsylvania
|
-$36.4M |
| 5 |
WP
Woodline Partners
San Francisco,
California
|
-$29.4M |
ARWR Hedge Fund Activity: Q4 2025 in Review
401 of the 8,263 institutional investors tracked by Wall St. Rank reported a position in Arrowhead Research (ARWR) for Q4 2025, worth a combined $7.71B — up 101% from $3.83B a quarter earlier.
Buyers outnumbered sellers: 127 funds opened new ARWR positions and 28 closed out — a net gain of 99 holders — while 125 added to existing stakes and 110 trimmed.
The largest buyer was Fred Alger Management, adding an estimated $74.8M. The largest seller was Slate Path Capital, cutting an estimated $120M.
- 401 institutional investors held Arrowhead Research (ARWR) as of Q4 2025, up from 304 in Q3 2025.
- Funds reported $7.71B of Arrowhead Research stock for Q4 2025, up 101% quarter-over-quarter.
- 127 funds opened new Arrowhead Research positions in Q4 2025 and 28 closed out, a net change of +99 holders.
- The largest Arrowhead Research buyer in Q4 2025 was Fred Alger Management, an estimated $74.8M added.
- The largest Arrowhead Research seller in Q4 2025 was Slate Path Capital, an estimated $120M sold.
Based on aggregated 13F filings for Q4 2025.