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5VM

5AM Venture Management Portfolio holdings

AUM $360M
1-Year Est. Return 345.76%
This Fund
S&P 500
This Quarter Est. Return
-4.72%
1 Year Est. Return
+345.76%
3 Year Est. Return
+491.51%
5 Year Est. Return
+330.26%
10 Year Est. Return
–
AUM
$419M
AUM Growth
-$65M
Cap. Flow
-$3.77M
Cap. Flow %
-0.9%
Top 10 Hldgs %
66.43%
Holding
32
New
4
Increased
–
Reduced
6
Closed
1

Top Buys

Rank Stock Value
1
CAMP icon
CAMP4 Therapeutics
CAMP
+$24.1M
2
AKRO
Akero Therapeutics
AKRO
+$5M
3
ALEC icon
Alector
ALEC
+$3.75M
4
TARA icon
Protara Therapeutics
TARA
+$2.58M

Top Sells

Rank Stock Value
1
PRAX icon
Praxis Precision Medicines
PRAX
+$12.3M
2
CNTA
Centessa Pharmaceuticals
CNTA
+$7.52M
3
COGT icon
Cogent Biosciences
COGT
+$6.07M
4
DNTH icon
Dianthus Therapeutics
DNTH
+$5.24M
5
ELVN icon
Enliven Therapeutics
ELVN
+$3.17M

Sector Composition

Rank Sector Weight
1 Healthcare 100%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
SLN
26
Silence Therapeutics
SLN
$527M
$3.28M 0.78%
476,200
– –
ADVM
27
DELISTED
Adverum Biotechnologies
ADVM
$2.53M 0.6%
541,666
– –
ALEC icon
28
Alector
ALEC
$171M
$1.88M 0.45%
+995,841
New +$3.75M
MRSN
29
DELISTED
Mersana Therapeutics
MRSN
$1.87M 0.45%
52,200
– –
CDTX
30
DELISTED
Cidara Therapeutics
CDTX
$1.52M 0.36%
56,725
– –
ZNTL icon
31
Zentalis Pharmaceuticals
ZNTL
$342M
$1.48M 0.35%
490,000
– –
COGT icon
32
Cogent Biosciences
COGT
$7.27B
– –
-561,854
Closed -$6.07M
1
2

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LSC
Logan Stone Capital Chicago, Illinois $360M AUM 9.71% 1-Year Est. Return
WIP
WealthCare Investment Partners Portsmouth, Rhode Island $360M AUM 19.98% 1-Year Est. Return
RA
RR Advisors Dallas, Texas $360M AUM 28.52% 1-Year Est. Return
SWM
SK Wealth Management Providence, Rhode Island $360M AUM 14.81% 1-Year Est. Return
NC
Naman Capital Sao Paulo, Brazil $360M AUM 27.43% 1-Year Est. Return
MCM
Monimus Capital Management Woodbridge, New Jersey $361M AUM 21.17% 1-Year Est. Return
KLWA
Kelly Lawrence W & Associates Pasadens, California $360M AUM 16.9% 1-Year Est. Return
PWC
PYA Waltman Capital Knoxville, Tennessee $361M AUM 9.49% 1-Year Est. Return

5AM Venture Management's Q4 2024 Portfolio in Review

As of Q4 2024, 5AM Venture Management held 32 positions worth $419M, down 13% from $484M the previous quarter. Its ten largest holdings account for 66% of the portfolio.

5AM Venture Management's Q4 2024 filing shows 4 new, 6 reduced and 1 closed positions. Its largest new stake was CAMP4 Therapeutics: 2,927,915 shares worth $15.3M. The largest sale was Praxis Precision Medicines, an estimated $12.3M.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, unchanged from a quarter earlier.

  • 5AM Venture Management's largest Q4 2024 buy was CAMP4 Therapeutics: 2,927,915 shares worth $15.3M.
  • 5AM Venture Management's biggest Q4 2024 reduction was Praxis Precision Medicines, cutting an estimated $12.3M.
  • 5AM Venture Management fully exited Cogent Biosciences in Q4 2024, selling an estimated $6.07M.
  • 5AM Venture Management's ten largest holdings make up 66% of its $419M portfolio in Q4 2024.
  • 5AM Venture Management opened 4 new positions and closed 1 in Q4 2024.
  • 5AM Venture Management's portfolio value fell 13% quarter-over-quarter to $419M.

Based on 5AM Venture Management's 13F filing for Q4 2024, filed 14 Feb 2025.