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Zymeworks
ZYME

211 hedge funds and large institutions have $1.76B invested in Zymeworks in 2026 Q1 according to their latest regulatory filings, with 40 funds opening new positions, 77 increasing their positions, 57 reducing their positions, and 35 closing their positions.

New
Increased
Maintained
Reduced
Closed

596% more call options, than puts

Call options by funds: $11.4M | Put options by funds: $1.63M

35% more repeat investments, than reductions

Existing positions increased: 77 | Existing positions reduced: 57

25% more funds holding in top 10

Funds holding in top 10: 4 → 5 (+1)

14% more first-time investments, than exits

New positions opened: 40 | Existing positions closed: 35

1% more funds holding

Funds holding: 209 → 211 (+2)

0.2% less ownership

Funds ownership: 95.49% → 95.3% (-0.2%)

6% less capital invested

Capital invested by funds: $1.88B → $1.76B (-$122M)

Holders
211
Holders Change
+2
Holders Change %
+0.96%
% of All Funds
2.6%
Holding in Top 10
5
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+25%
% of All Funds
0.06%
New
40
Increased
77
Reduced
57
Closed
35
Calls
$11.4M
Puts
$1.63M
Net Calls
+$9.74M
Net Calls Change
+$395K

Top Buyers

1
RCMNY
Rubric Capital Management (New York)
New York
+$29.6M
2
Citadel Advisors
Citadel Advisors
Florida
+$21.2M
3
MB
MPM BioImpact
Massachusetts
+$13.4M
4
RA
Royce & Associates
New York
+$7.08M
5
PA
Perceptive Advisors
New York
+$5.87M

Top Sellers

1
SL
Siren LLC
Connecticut
-$44.2M
2
VPC
Vestal Point Capital
New York
-$22.8M
3
Adage Capital Partners
Adage Capital Partners
Massachusetts
-$17.5M
4
Deutsche Bank
Deutsche Bank
Germany
-$16M
5
AG
Algert Global
California
-$11.2M
Name Holding Trade Value Shares
Change 		Change in
Stake
TPWA
201
Twin Peaks Wealth Advisors
California
$501 +$473 +20 New
ACM
202
Aster Capital Management
United Arab Emirates
$500 +$994 +42 New
CA
203
CoreCap Advisors
Michigan
$451 – – –
EP
204
Essential Partners
California
$300 – – –
RFP
205
Root Financial Partners
California
$300 +$284 +12 New
SAM
206
Smartleaf Asset Management
Massachusetts
$291 – – –
SS
207
SBI Securities
Japan
$275 – – –
CCA
208
Cygnus Capital Advisors
Georgia
$205 +$52.1K +2,200 +37%
MCM
209
MAI Capital Management
Ohio
$176 +$47 +2 +40%
LFG
210
Larson Financial Group
Missouri
$150 – – –
HFS
211
Hughes Financial Services
Virginia
$100 +$95 +4 New
SL
212
Siren LLC
Connecticut
– -$44.2M -1,680,121 Closed
VPC
213
Vestal Point Capital
New York
– -$22.8M -865,000 Closed
Adage Capital Partners
214
Adage Capital Partners
Massachusetts
– -$17.5M -663,546 Closed
AG
215
Algert Global
California
– -$11.2M -423,646 Closed
Millennium Management
216
Millennium Management
New York
– -$9.03M -381,621 Closed
SSA
217
Schonfeld Strategic Advisors
New York
– -$7.6M -288,571 Closed
Renaissance Technologies
218
Renaissance Technologies
New York
– -$5.82M -220,877 Closed
JAM
219
Jupiter Asset Management
United Kingdom
– -$3.3M -125,506 Closed
OM
220
Opaleye Management
Massachusetts
– -$2.87M -108,929 Closed
TI
221
Trexquant Investment
Connecticut
– -$2.67M -101,274 Closed
ACP
222
Acuta Capital Partners
California
– -$2.11M -80,143 Closed
NIM
223
NEOS Investment Management
Connecticut
– -$2.03M -77,115 Closed
PCM
224
Penserra Capital Management
California
– -$1.58M -60,146 Closed
TCM
225
Tang Capital Management
California
– -$912K -34,631 Closed
6 7 8
9
10

ZYME Hedge Fund Activity: Q1 2026 in Review

211 of the 8,126 institutional investors tracked by Wall St. Rank reported a position in Zymeworks (ZYME) for Q1 2026, worth a combined $1.76B — down 6.5% from $1.88B a quarter earlier.

Buyers outnumbered sellers: 40 funds opened new ZYME positions and 35 closed out — a net gain of 5 holders — while 77 added to existing stakes and 57 trimmed.

The largest buyer was Rubric Capital Management (New York), adding an estimated $29.6M. The largest seller was Siren LLC, exiting entirely with an estimated $44.2M sold.

  • 211 institutional investors held Zymeworks (ZYME) as of Q1 2026, up from 209 in Q4 2025.
  • Funds reported $1.76B of Zymeworks stock for Q1 2026, down 6.5% quarter-over-quarter.
  • 40 funds opened new Zymeworks positions in Q1 2026 and 35 closed out, a net change of +5 holders.
  • The largest Zymeworks buyer in Q1 2026 was Rubric Capital Management (New York), an estimated $29.6M added.
  • The largest Zymeworks seller in Q1 2026 was Siren LLC, an estimated $44.2M sold.

Based on aggregated 13F filings for Q1 2026.