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Zymeworks
ZYME

181 hedge funds and large institutions have $949M invested in Zymeworks in 2025 Q2 according to their latest regulatory filings, with 29 funds opening new positions, 62 increasing their positions, 55 reducing their positions, and 30 closing their positions.

New
Increased
Maintained
Reduced
Closed

376% more call options, than puts

Call options by funds: $4.2M | Put options by funds: $883K

13% more capital invested

Capital invested by funds: $841M → $949M (+$108M)

13% more repeat investments, than reductions

Existing positions increased: 62 | Existing positions reduced: 55

7.23% more ownership

Funds ownership: 101.45% → 108.68% (+7.2%)

0% more funds holding in top 10

Funds holding in top 10: 5 → 5 (0)

3% less first-time investments, than exits

New positions opened: 29 | Existing positions closed: 30

2% less funds holding

Funds holding: 184 → 181 (-3)

Holders
181
Holders Change
-3
Holders Change %
-1.63%
% of All Funds
2.38%
Holding in Top 10
5
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.07%
New
29
Increased
62
Reduced
55
Closed
30
Calls
$4.2M
Puts
$883K
Net Calls
+$3.32M
Net Calls Change
+$154K

Top Buyers

Rank Fund Capital Flow
1
EC
EcoR1 Capital
California
+$68M
2
Vanguard Group
Vanguard Group
Pennsylvania
+$8.31M
3
VPC
Vestal Point Capital
New York
+$7.74M
4
Adage Capital Partners
Adage Capital Partners
Massachusetts
+$5.67M
5
N
Nuveen
North Carolina
+$5.43M

Top Sellers

Rank Fund Capital Flow
1
UBS AM
UBS AM
Illinois
-$16.9M
2
BCM
Bridgeway Capital Management
Texas
-$9.13M
3
RG
Redmile Group
California
-$7.6M
4
PA
Perceptive Advisors
New York
-$7.02M
5
FCM
Farallon Capital Management
California
-$4.76M
Name Holding Trade Value Shares
Change 		Change in
Stake
GIM
26
Granahan Investment Management
Massachusetts
$4.78M -$319K -26,806 -7%
JAM
27
Jupiter Asset Management
United Kingdom
$4.64M – – –
Northern Trust
28
Northern Trust
Illinois
$4.39M -$442K -37,124 -10%
SB
29
Samsara BioCapital
California
$3.89M -$4.25M -356,367 -53%
Schroder Investment Management Group
30
Schroder Investment Management Group
United Kingdom
$3.8M -$206K -17,283 -5%
SAM
31
Silvercrest Asset Management
New York
$3.52M – – –
Susquehanna International Group
32
Susquehanna International Group
Pennsylvania
$3.25M -$1.1M -92,024 -26%
D.E. Shaw & Co
33
D.E. Shaw & Co
New York
$3.2M +$2.29M +192,192 +305%
UBS Group
34
UBS Group
Switzerland
$3.16M +$443K +37,210 +17%
Citadel Advisors
35
Citadel Advisors
Florida
$3.09M +$780K +65,485 +36%
PIM
36
Platinum Investment Management
Australia
$2.99M -$480K -40,267 -14%
TI
37
Trexquant Investment
Connecticut
$2.77M +$2.06K +173 +0.1%
OM
38
Opaleye Management
Massachusetts
$2.64M +$417K +35,000 +20%
PMAM
39
Picton Mahoney Asset Management
Ontario, Canada
$2.6M -$5.09K -427 -0.2%
HIM
40
Hillsdale Investment Management
Ontario, Canada
$2.57M -$380K -31,903 -13%
Norges Bank
41
Norges Bank
Norway
$2.53M – – –
TC
42
Tejara Capital
United Kingdom
$2.51M +$128K +10,741 +6%
Federated Hermes
43
Federated Hermes
Pennsylvania
$2.29M +$4.26K +358 +0.2%
Wellington Management Group
44
Wellington Management Group
Massachusetts
$2.27M -$18.5K -1,556 -0.9%
Axa
45
Axa
France
$2.2M +$2.09M +175,121 New
Wells Fargo
46
Wells Fargo
California
$2.09M +$788K +66,119 +66%
AQR Capital Management
47
AQR Capital Management
Connecticut
$2.09M +$1.4M +117,658 +243%
Citigroup
48
Citigroup
New York
$1.96M +$1.37M +114,800 +279%
Squarepoint
49
Squarepoint
New York
$1.95M +$1.1M +91,997 +145%
KCM
50
Kennedy Capital Management
Missouri
$1.84M +$127K +10,635 +8%
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ZYME Hedge Fund Activity: Q2 2025 in Review

181 of the 7,596 institutional investors tracked by Wall St. Rank reported a position in Zymeworks (ZYME) for Q2 2025, worth a combined $949M — up 13% from $841M a quarter earlier.

Sellers outnumbered buyers: 30 funds closed out of ZYME and 29 opened new positions — a net loss of 1 holder — while 55 trimmed existing stakes and 62 added.

The largest buyer was EcoR1 Capital, adding an estimated $68M. The largest seller was UBS AM, cutting an estimated $16.9M.

  • 181 institutional investors held Zymeworks (ZYME) as of Q2 2025, down from 184 in Q1 2025.
  • Funds reported $949M of Zymeworks stock for Q2 2025, up 13% quarter-over-quarter.
  • 29 funds opened new Zymeworks positions in Q2 2025 and 30 closed out, a net change of -1 holder.
  • The largest Zymeworks buyer in Q2 2025 was EcoR1 Capital, an estimated $68M added.
  • The largest Zymeworks seller in Q2 2025 was UBS AM, an estimated $16.9M sold.

Based on aggregated 13F filings for Q2 2025.