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Zymeworks
ZYME

Overview Fund Activity

183 hedge funds and large institutions have $839M invested in Zymeworks in 2025 Q1 according to their latest regulatory filings, with 31 funds opening new positions, 60 increasing their positions, 64 reducing their positions, and 18 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
183
Holders Change
+11
Holders Change %
+6.4%
% of All Funds
2.49%
Holding in Top 10
5
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.07%
New
31
Increased
60
Reduced
64
Closed
18
Calls
$3.46M
Puts
$296K
Net Calls
+$3.17M
Net Calls Change
+$2.89M

Top Buyers

1
UBS AM
UBS AM
Illinois
+$30M
2
EC
EcoR1 Capital
California
+$26.6M
3
Blackstone Inc
Blackstone Inc
New York
+$9.68M
4
RCMNY
Rubric Capital Management (New York)
New York
+$5.02M
5
VPC
Vestal Point Capital
New York
+$3.75M

Top Sellers

1
CW
Curio Wealth
Maryland
-$14.6M
2
FCM
Farallon Capital Management
California
-$11.1M
3
Vanguard Group
Vanguard Group
Pennsylvania
-$8.65M
4
Point72 Asset Management
Point72 Asset Management
Connecticut
-$4.83M
5
Jacobs Levy Equity Management
Jacobs Levy Equity Management
New Jersey
-$4.1M
Name Holding Trade Value Shares
Change 		Shares
Change %
Northern Trust
26
Northern Trust
Illinois
$4.61M -$94.2K -7,907 -2%
JAM
27
Jupiter Asset Management
United Kingdom
$4.4M – – –
EF
28
Empowered Funds
Pennsylvania
$4.29M +$86.8K +7,291 +2%
Susquehanna International Group
29
Susquehanna International Group
Pennsylvania
$4.18M +$3.57M +299,645 +582%
Schroder Investment Management Group
30
Schroder Investment Management Group
United Kingdom
$3.98M -$188K -15,212 -5%
Millennium Management
31
Millennium Management
New York
$3.52M +$3.52M +295,606 New
SAM
32
Silvercrest Asset Management
New York
$3.34M -$19.3K -1,619 -0.6%
PIM
33
Platinum Investment Management
Australia
$3.32M -$331K -27,802 -9%
Walleye Capital
34
Walleye Capital
New York
$2.95M -$2.44M -204,845 -45%
HIM
35
Hillsdale Investment Management
Ontario, Canada
$2.82M +$82.2K +6,900 +3%
TI
36
Trexquant Investment
Connecticut
$2.63M +$1.42M +118,813 +116%
UBS Group
37
UBS Group
Switzerland
$2.55M +$565K +47,404 +28%
PMAM
38
Picton Mahoney Asset Management
Ontario, Canada
$2.48M +$17.4K +1,460 +0.7%
Goldman Sachs
39
Goldman Sachs
New York
$2.38M -$594K -49,913 -20%
NL
40
Nuveen LLC
North Carolina
$2.37M +$2.37M +198,812 New
TC
41
Tejara Capital
United Kingdom
$2.26M +$1.8M +150,872 +391%
Wellington Management Group
42
Wellington Management Group
Massachusetts
$2.17M -$439K -36,852 -17%
Federated Hermes
43
Federated Hermes
Pennsylvania
$2.17M +$3.41K +286 +0.2%
Citadel Advisors
44
Citadel Advisors
Florida
$2.15M +$1.46M +122,312 +210%
OM
45
Opaleye Management
Massachusetts
$2.08M +$2.08M +175,000 New
KCM
46
Kennedy Capital Management
Missouri
$1.62M -$43.3K -3,634 -3%
Jane Street
47
Jane Street
New York
$1.62M +$1.34M +112,636 +487%
Charles Schwab
48
Charles Schwab
California
$1.59M +$27.8K +2,333 +2%
ECM
49
ExodusPoint Capital Management
New York
$1.59M +$1.59M +133,320 New
Bank of New York Mellon
50
Bank of New York Mellon
New York
$1.44M +$524 +44 +0%
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