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Wave Life Sciences

196 hedge funds and large institutions have $1.06B invested in Wave Life Sciences in 2025 Q1 according to their latest regulatory filings, with 33 funds opening new positions, 83 increasing their positions, 52 reducing their positions, and 20 closing their positions.

New
Increased
Maintained
Reduced
Closed

164% more call options, than puts

Call options by funds: $4.91M | Put options by funds: $1.86M

65% more first-time investments, than exits

New positions opened: 33 | Existing positions closed: 20

60% more repeat investments, than reductions

Existing positions increased: 83 | Existing positions reduced: 52

7% more funds holding

Funds holding: 183196 (+13)

1.28% more ownership

Funds ownership: 84.33%85.6% (+1.3%)

0% more funds holding in top 10

Funds holding in top 10: 44 (0)

33% less capital invested

Capital invested by funds: $1.59B → $1.06B (-$529M)

Holders
196
Holders Change
+13
Holders Change %
+7.1%
% of All Funds
2.63%
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
0.05%
New
33
Increased
83
Reduced
52
Closed
20
Calls
$4.91M
Puts
$1.86M
Net Calls
+$3.05M
Net Calls Change
-$854K
Name Holding Trade Value Shares
Change
Change in
Stake
BNP Paribas Financial Markets
51
BNP Paribas Financial Markets
France
$1.89M +$993K +90,811 +64%
TI
52
Trexquant Investment
Connecticut
$1.81M -$2.36M -215,940 -49%
Wells Fargo
53
Wells Fargo
California
$1.8M +$1.89M +173,106 +347%
EI
54
EAM Investors
California
$1.73M -$9.5K -869 -0.4%
Renaissance Technologies
55
Renaissance Technologies
New York
$1.7M +$1.84M +168,700 +406%
DFCM
56
Dark Forest Capital Management
Puerto Rico
$1.59M +$1.89M +173,065 +717%
Swiss National Bank
57
Swiss National Bank
Switzerland
$1.55M -$184K -16,800 -8%
UBS AM
58
UBS AM
Illinois
$1.48M +$199K +18,164 +11%
UBS Group
59
UBS Group
Switzerland
$1.36M +$505K +46,174 +38%
Manulife (Manufacturers Life Insurance)
60
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$1.26M -$568K -51,901 -25%
Verition Fund Management
61
Verition Fund Management
Connecticut
$1.25M +$797K +72,874 +89%
TD Asset Management
62
TD Asset Management
Ontario, Canada
$1.25M -$1.77M -161,798 -51%
New York State Common Retirement Fund
63
New York State Common Retirement Fund
New York
$1.22M +$453K +41,429 +38%
RhumbLine Advisers
64
RhumbLine Advisers
Massachusetts
$1.07M +$86K +7,860 +6%
Connor, Clark & Lunn Investment Management (CC&L)
65
Connor, Clark & Lunn Investment Management (CC&L)
British Columbia, Canada
$1.02M -$2.86M -261,825 -68%
JJBC
66
James J. Burns & Company
New York
$985K +$118K +10,802 +10%
Susquehanna International Group
67
Susquehanna International Group
Pennsylvania
$946K +$837K +76,558 +189%
Legal & General Group
68
Legal & General Group
United Kingdom
$938K -$28.9K -2,642 -2%
EGM
69
Engineers Gate Manager
New York
$935K +$802K +73,289 +173%
PFM
70
Privium Fund Management
Netherlands
$917K +$279K +25,550 +29%
PCM
71
Prelude Capital Management
New York
$883K +$1.2M +109,330 New
D.E. Shaw & Co
72
D.E. Shaw & Co
New York
$861K -$6.67M -609,699 -85%
State of Wisconsin Investment Board
73
State of Wisconsin Investment Board
Wisconsin
$856K +$274K +25,075 +31%
HSA
74
Hussman Strategic Advisors
Maryland
$848K +$689K +63,000 +150%
Norges Bank
75
Norges Bank
Norway
$808K

WVE Hedge Fund Activity: Q1 2025 in Review

196 of the 7,457 institutional investors tracked by Wall St. Rank reported a position in Wave Life Sciences (WVE) for Q1 2025, worth a combined $1.06B — down 33% from $1.59B a quarter earlier.

Buyers outnumbered sellers: 33 funds opened new WVE positions and 20 closed out — a net gain of 13 holders — while 83 added to existing stakes and 52 trimmed.

The largest buyer was Adage Capital Partners, adding an estimated $31.7M. The largest seller was Millennium Management, cutting an estimated $12.6M.

  • 196 institutional investors held Wave Life Sciences (WVE) as of Q1 2025, up from 183 in Q4 2024.
  • Funds reported $1.06B of Wave Life Sciences stock for Q1 2025, down 33% quarter-over-quarter.
  • 33 funds opened new Wave Life Sciences positions in Q1 2025 and 20 closed out, a net change of +13 holders.
  • The largest Wave Life Sciences buyer in Q1 2025 was Adage Capital Partners, an estimated $31.7M added.
  • The largest Wave Life Sciences seller in Q1 2025 was Millennium Management, an estimated $12.6M sold.

Based on aggregated 13F filings for Q1 2025.