Twist Bioscience
TWST
280 hedge funds and large institutions have $3.66B invested in Twist Bioscience in 2026 Q1 according to their latest regulatory filings, with 70 funds opening new positions, 76 increasing their positions, 88 reducing their positions, and 27 closing their positions.
159% more first-time investments, than exits
New positions opened: 70 | Existing positions closed: 27
75% more call options, than puts
Call options by funds: $10.8M | Put options by funds: $6.18M
54% more capital invested
Capital invested by funds: $2.38B → $3.66B (+$1.28B)
25% more funds holding in top 10
Funds holding in top 10: 4 → 5 (+1)
15% more funds holding
Funds holding: 244 → 280 (+36)
2.94% more ownership
Funds ownership: 122.67% → 125.6% (+2.9%)
14% less repeat investments, than reductions
Existing positions increased: 76 | Existing positions reduced: 88
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Fidelity Investments
Boston,
Massachusetts
|
+$81.6M |
| 2 |
FCM
Farallon Capital Management
San Francisco,
California
|
+$63.7M |
| 3 |
Citadel Advisors
Miami,
Florida
|
+$53.3M |
| 4 |
Invesco
Atlanta,
Georgia
|
+$39.5M |
| 5 |
Point72 Asset Management
Stamford,
Connecticut
|
+$30M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
AIM
ARK Investment Management
St. Petersburg,
Florida
|
-$54.6M |
| 2 |
Millennium Management
New York
|
-$51.4M |
| 3 |
American Century Companies
Kansas City,
Missouri
|
-$37.1M |
| 4 |
William Blair Investment Management
Chicago,
Illinois
|
-$30.7M |
| 5 |
SCM
Soleus Capital Management
Greenwich,
Connecticut
|
-$28.5M |
TWST Hedge Fund Activity: Q1 2026 in Review
280 institutional investors reported a position in Twist Bioscience (TWST) for Q1 2026, worth a combined $3.66B — up 54% from $2.38B a quarter earlier.
Buyers outnumbered sellers: 70 funds opened new TWST positions and 27 closed out — a net gain of 43 holders — while 76 added to existing stakes and 88 trimmed.
The largest buyer was Fidelity Investments, adding an estimated $81.6M. The largest seller was ARK Investment Management, cutting an estimated $54.6M.
- 280 institutional investors held Twist Bioscience (TWST) as of Q1 2026, up from 244 in Q4 2025.
- Funds reported $3.66B of Twist Bioscience stock for Q1 2026, up 54% quarter-over-quarter.
- 70 funds opened new Twist Bioscience positions in Q1 2026 and 27 closed out, a net change of +43 holders.
- The largest Twist Bioscience buyer in Q1 2026 was Fidelity Investments, an estimated $81.6M added.
- The largest Twist Bioscience seller in Q1 2026 was ARK Investment Management, an estimated $54.6M sold.
Based on aggregated 13F filings for Q1 2026.